Protein Alignment fwd and pi4kb

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_005158276.1
• Gene: pi4kb / 563201
• ZFINID: ZDB-GENE-061013-96
• Length: 850
• Species: Danio rerio
• Alignment Length: 946
• Identity: 383/946 - (40%)
• Similarity: 544/946 - (57%)
• Gaps: 142/946 - (15%)

  Fly   771 DLVKSPTDISK-KKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQPLSDPSA 834
            :|..|||.:.: :|...:..|||.|:.::.::..:...|:.|:| :|.|         |.|.|..
Zfish     5 ELELSPTHLEELQKSPSTSTTSSLSLPSSPSSGPHPLTSSSPST-SEGL---------PTSSPPL 59

  Fly   835 DLKVKERTLNLRLPGDSEGSEGALTKCSSINSIHKLK-LPVPGVV-------------------- 878
            |: :.|....|.|..|:|.::.|   |..:  :.|:| |...|.|
Zfish    60 DV-ISEGLGELSLVIDTEVAKKA---CQEV--LQKVKFLKGDGEVSSASSEPILANGTAHPEAND 118

  Fly   879 -----KYFISEKAPVSDVLQKPEKG---QSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNK 935
                 |....|..|:..|.::.:..   ||.|||.|||.:|:|..|:.||:.||||||.::|||:
Zfish   119 GGQPPKISEEEVEPIKSVRRRQKNNSSKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNR 183

  Fly   936 IFSFPDQEVDLYIPQLVVMYIQMDE-LAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGN 999
            :|||.:::||.|:|||:.|||.||| :.:.:.||:..|||:|::|||:|.|||.||:..:.....
Zfish   184 LFSFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYVVYRCRQSINFSLQCAWLLGAYSSDMHISTQ 248

  Fly  1000 SHNSSRK-SKLALMKEIFSKREHKQTQNDLKSAG---TGGLHVGEPRSVVAL--AKKTHHRSQSD 1058
            .|:...| .||.|..|:  |...::.:.::....   ...||.|...|..:|  :|:||.||:||
Zfish   249 RHSRGTKLRKLILSDEL--KPSSQRIRREVPQPPPPYPPPLHHGPGMSEHSLSPSKRTHQRSKSD 311

  Fly  1059 ATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNG 1123
            |||         ::|:|..:.:     |.:.|..                      ||.:.:...
Zfish   312 ATV---------SISLSSNLKR-----TASNPKV----------------------ETSQDEDLS 340

  Fly  1124 LLGQRTLCSCGAP-KTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPL 1187
            ..........|.| :.:||:||:|:||.:||.|.:.|:|.:||..|...|:|:|..||||||||.
Zfish   341 SSSDSLELEAGTPVRLTPQREFIKSLMGIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPT 405

  Fly  1188 YSDIPHHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMP--SLRHTKSEEHLDG 1250
             :...|||||:...:..|||||||.||:|||||:|..:..||. :|..:|  .:|.|:|.|:|..
Zfish   406 -AAFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFETSS-VPVRIPETQIRSTRSVENLPD 468

  Fly  1251 SCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWS 1315
            ..:...|     |.||.|:.                      |:..            .:|:.||
Zfish   469 CGITPDQ-----RASSFSTV----------------------PNYD------------NDDEAWS 494

  Fly  1316 QEEDEITAQYLNMRKV--SERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFS 1378
              .|:|....:.:.::  :..|.|||.|:||..|::...|:....||:|.|....|:...| :|.
Zfish   495 --VDDIGELQVELPEIHTNSCDNISQFSVDSITSQESKEPIFIAAGDIRRRLSEQLAHTPT-TFR 556

  Fly  1379 NDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQ 1443
            .|||||||.||||||.||.:.|||.||||||.||||||.||||||||||||:|.|:|:..:|||:
Zfish   557 KDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAYQVLKQLQIIWE 621

  Fly  1444 EEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKN 1508
            :|:|.||::||||:.:|:|||:|||::|.||:||:||.|...|.:||..|:|:.:.|.|..||:|
Zfish   622 QERVPLWIKPYKILVISSDSGMIEPVVNAVSIHQVKKQSQLLLLDYFRQEHGNFNTEEFLTAQRN 686

  Fly  1509 FVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEV 1573
            ||||||.||||.||||||||||||||..|:|||||||||||||.||:|||||.|.||||.|||:|
Zfish   687 FVQSCAGYCLICYLLQVKDRHNGNILLDSEGHIIHIDFGFILSSSPRNLGFETSAFKLTSEFVDV 751

  Fly  1574 MGGTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNL 1638
            |||...:.:..:..|:|.|:::|||||:::|..||||:..:.||||..  |.|::||::||||||
Zfish   752 MGGLDGDMFNYYKMLMLQGLIAARKHMEKVIQIVEIMQQGSQLPCFHG--SSTIRNLKERFHMNL 814

  Fly  1639 TEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGIL 1674
            ||::::..|||:|..|::|::||||||:||.||||:
Zfish   815 TEEQLQVLVEQMVDGSMRSITTKLYDGFQYLTNGIM 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	179/288 (62%)
pi4kb	XP_005158276.1	PI4KB_NTD	2..96	CDD:412074	28/106 (26%)
		PI4Kc_III_beta	563..850	CDD:270712	179/288 (62%)