Protein Alignment fwd and PI4KB

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_011507936.1
• Gene: PI4KB / 5298
• HGNCID: 8984
• Length: 849
• Species: Homo sapiens
• Alignment Length: 962
• Identity: 362/962 - (37%)
• Similarity: 522/962 - (54%)
• Gaps: 191/962 - (19%)

  Fly   760 GSP--NGGSSV--------------PQDLVKSPTDISKKKEFFSLLTSSSSIKAAAAAAANSAAS 808
            |.|  ||||.:              |:...|:..::.:|            :|......|.|:.
Human    32 GPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEK------------VKLLHGGVAVSSR- 83

  Fly   809 TPPATPTEALAANS-NSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEGALTKCSSINSIHKLKL 872
               .||.|.:..:. :|:::.|.||.|.::            :.|...||.....:.....:.:
Human    84 ---GTPLELVNGDGVDSEIRCLDDPPAQIR------------EEEDEMGAAVASGTAKGARRRR- 132

  Fly   873 PVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIF 937
                                |.....||.|||.|||.:|:|..|:.||:.||||||.::|||::|
Human   133 --------------------QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLF 177

  Fly   938 SFPDQEVDLYIPQLVVMYIQMDE-LAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSH 1001
            .|.:::||.|:|||:.|||.||| :.:.:.||:..|||:|::|||:|..||.||:..:......|
Human   178 CFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRH 242

  Fly  1002 NSSRKSKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADF 1066
            :...|.:..::.:.......|:....|..|...||         :.:|:||.||:||||.
Human   243 SRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGL---------SPSKRTHQRSKSDATA----- 293

  Fly  1067 RSPHTLSIS---HRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQR 1128
                ::|:|   .|....|....:....:         :|..:.||
Human   294 ----SISLSSNLKRTASNPKVENEDEELS---------SSTESIDN------------------- 326

  Fly  1129 TLCSCGAP-KTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYSDIP 1192
               |..:| :.:|::||:|:||.:||.|.:.|:|.:||..|...|:|:|..||||||||. :...
Human   327 ---SFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPT-AGFD 387

  Fly  1193 HHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPS--LRHTKSEEHLDGSCLNS 1255
            |||||:...:..|||||||.||:|||||:|..:..|:. :|..:|.  :|.|:|.|:|. .|..:
Human   388 HHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTS-VPARIPENRIRSTRSVENLP-ECGIT 450

  Fly  1256 HQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDE 1320
            |:.                               .||..::..|..:       :|:.||  .|:
Human   451 HEQ-------------------------------RAGSFSTVPNYDN-------DDEAWS--VDD 475

  Fly  1321 ITAQYLNMRKV--SERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPED 1383
            |....:.:.:|  :..|.|||.|:||..|::...||....||:|.|....|:...| :|..||||
Human   476 IGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPT-AFKRDPED 539

  Fly  1384 PSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVD 1448
            |||.||||||.||.:.|||.||||||.||||||.||||||||||||:|.|:|:..:.||::|:|.
Human   540 PSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVP 604

  Fly  1449 LWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSC 1513
            ||::||||:.:|.|||:|||::|.||:||:||.|..||.:||:.|:||.:.|:|..||:||||||
Human   605 LWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSC 669

  Fly  1514 AAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGTS 1578
            |.|||:.||||||||||||||..::|||||||||||||.||:|||||.|.||||.|||:||||..
Human   670 AGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLD 734

  Fly  1579 SEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSN---------------------AHLPCFKNG 1622
            .:.:..:..|:|.|:::||||||:::..||||:..                     :.||||..
Human   735 GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFHG- 798

  Fly  1623 CSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGIL 1674
             |.|::||::||||::||::::..|||:|..|::|::||||||:||.||||:
Human   799 -SSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	176/309 (57%)
PI4KB	XP_011507936.1	PI4KB_NTD	14..78	CDD:412074	10/57 (18%)
		PI4Kc_III_beta	541..849	CDD:270712	176/309 (57%)