Protein Alignment fwd and Pi3K68D

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_524028.2
• Gene: Pi3K68D / 39329
• FlyBaseID: FBgn0015278
• Length: 1876
• Species: Drosophila melanogaster
• Alignment Length: 1693
• Identity: 328/1693 - (19%)
• Similarity: 551/1693 - (32%)
• Gaps: 461/1693 - (27%)

  Fly   254 TLPIGGQMPTIKCLPGASSAASTPKHSRYSKPRLSLSRVFNHSMPSVHGRPNLSLAPAG--VPGS 316
            |.|..|....:.|.     |:.|.|....|.|...|........|:   .|..:|.|.|  ...|
  Fly    87 TPPAQGTDNDLICF-----ASPTSKQPESSSPFGKLIEDLQRMQPT---NPQSALVPMGPVASAS 143

  Fly   317 VNPPKRISTH-QRNLSLDFRSMGI---------------LLP--PVSQVTNNHINHTQHHRNRSL 363
            :.|......| ||..:......|:               |:|  |.:| ....:|..:..|..|:
  Fly   144 IPPQYGFPPHQQRPTAAQPTPYGMVAGGVVGGPAYGDLQLVPYQPAAQ-QQRPLNSEELQRLYSM 207

  Fly   364 DSALQRIPEVEVSSPNA------ESENTFCSPSILGATMCSKIATTAATVTSALSPPGTPT---- 418
            .:.:..:|   |..|||      .....:.:|.:.|              ::|..||..|.
  Fly   208 PAQMAVVP---VPQPNAYMYYPGAVVTPYTAPIVPG--------------SAAFMPPQYPAQGYG 255

  Fly   419 ----------------PALMSTACTPTIGAVKGNVQHPVPKHEQSISLAAACRSSAVVESCPTLR 467
                            ||...||  ||.     :..|..|.:..:.|.|.|   :.|  :.|..|
  Fly   256 FGGAYTHMDLRRPQSQPAPQQTA--PTT-----SHHHSQPSNHSTSSPAEA---NGV--AFPARR 308

  Fly   468 MRPKSSESVAANGQEMIGVIVSS-TGNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIICGSESD 531
            ..|.:           :||..|| |||...||        ..::..||..|..:|...:...|:.
  Fly   309 QVPST-----------VGVSSSSHTGNNGHSS--------VPRRGNDLIDLNHEDYSRVSVLEAF 354

  Fly   532 QISLNRICHSHESLDSGEMDAD----------------ADAEEECVDLMDTT------------- 567
            ...||....:..:.||....|:                :|...|.|:..|.|
  Fly   355 DPLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGW 419

  Fly   568 ---------SIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQI 623
                     :...:|.:..|:.........:.|......|.|..:|..:..|.....:.|.|:.:
  Fly   420 RQDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSV 484

  Fly   624 ESEDSVDAGVDARTRYRVMNMSQAAINV-ELGTASNEIDP----------DVNYRESHQDPIADA 677
            .: ||..:.:.|..   |::..:....: ||.:.....||          :|..|..|.    ||
  Fly   485 LT-DSYTSSIPANV---VLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHD----DA 541

  Fly   678 PS---------------LSTPSVASTASATPSVTPTPIATPTPTESTK--NDQVLFKNFFGATKN 725
            |:               :.|........|..::..|.:|.....|..|  ...|.|.....:...
  Fly   542 PTNVGHVVAAEFNYHYMMDTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVA 606

  Fly   726 AIFRTAQSIIENHEKKNAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISKKKEFFSLLT 790
            .:...|.:.:|...|........:|  .|.:..:...:..|.:  :.|.:...:.|.......|:
  Fly   607 QVVAQALASLEGQVKGTVTDYAVKP--IGLLEWLAPTSRLSQL--ECVHNSFQLEKDVHLGLCLS 667

  Fly   791 SSSSIKAAAAAAANSA--ASTPP--ATPTEALAANSNSKLQPLSDPSADLKVKERTLNL---RLP 848
            ::::::|.|....:..  |...|  ..|.|.:...:...:..|.:          ||.:   :|.
  Fly   668 TAANMQAIARTERDDEHDADLLPEHLLPNEVVPIVTYDNMMILIE----------TLEMEIDKLE 722

  Fly   849 GDSEGSEG-ALTKCSSINSIHKLKLPVPGVV---------------------KY--------FIS 883
            ..::|..| ::..||.:....|....:.|.:                     ||        .:|
  Fly   723 SAADGVPGRSVVSCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEVEQKKYSTGASNPEIVS 787

  Fly   884 EKAPVSDVLQKPEK--------------GQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGN 934
            :....:.|:.:|..              ....|:..:.: ||.:.|:|....||..|..:|.:..
  Fly   788 DYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYAN-VFRVAFSVKTPDYSTTPIPISCVSK 851

  Fly   935 KIF--------SFPDQEVDLYIPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYN 991
            .|.        ..|:.:.|.|     .:.:|:.....:|.....:.|.......     |....|
  Fly   852 PIVVCISCLHRPLPNWKFDDY-----SLCVQIVYGTRLLSKPNVLTCSNDTSGG-----LFPRLN 906

  Fly   992 YQVDSLGNSH---NSSRKSKLALM---KEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKK 1050
            :......:.|   ...|:::|..:   |:..|:.|....||            ||.|.|..
  Fly   907 FSAWLTFDQHPICTLPREARLTFVLYGKQAASEGEPNADQN------------GERRQVTT---- 955

  Fly  1051 THHRSQSDATVLLADFR-----SPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNG 1110
                .....::.|.||:     .|:.||:      .||.|.:.|...||:.|       |...:.
  Fly   956 ----ELGWCSIQLFDFKRVMICGPYLLSL------WPPMTDKMLGPAPARGC-------HPQPDF 1003

  Fly  1111 CTCFE----TVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKN----------------- 1154
            |....    ...|::.....|.      .||.:|..:|.....|:.:.
  Fly  1004 CPVLSIEVPPYGGRIEFPEHQE------VPKPAPHYDFASLDANLQEELLDTAELGYTGATERRE 1062

  Fly  1155 --------LTSWPSKAEKTSALRMS---LNLINKNLPARVWLPLYS------DIPHHVVRITEEK 1202
                    |.|:|:...|......|   .|||:.:.....|.||..      .:|.:......||
  Fly  1063 VFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREK 1127

  Fly  1203 TAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKSE-----EHLDGSCLNS------- 1255
            .....||             :|:......:|:::.||:|...|     ..|...||.|
  Fly  1128 AVEWISK-------------MPNDQLVDFLPQLVQSLKHDTYEGSAMARFLLSKCLESPRFAHHM 1179

  Fly  1256 ------------HQHLSCSRTSSCSSSQQGTSC---RRKKG--ADVDGGCGD------AGPHNSC 1297
                        |..:..:.........|.|..   ||.|.  ..:...||:      ...|..|
  Fly  1180 YWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMC 1244

  Fly  1298 SNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVS---ERDTISQISLDSCDSRDQGPPVVFNIG 1359
            ..:.::.      :.|...:|        :||:.|   ..|.:.|..|:.......||.:  .:.
  Fly  1245 QKLTTIA------ESVKEAKE--------SMRQKSLAAGMDEVHQDLLEQPTCLPLGPEL--EVT 1293

  Fly  1360 DVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDD 1424
            .|.:|:||..: .||.....:...|.|               ||.|           ||.|||||
  Fly  1294 GVSVRNCSYFN-SNTLPLKINFVGPDA---------------ESLP-----------AIFKCGDD 1331

  Fly  1425 LRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLH--QIKKNSNKSLK 1487
            |:|:.:..||:::...:|..|::||.:..:..|.....||:||.:....:|.  |::.....|.|
  Fly  1332 LQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFK 1396

  Fly  1488 EYFIDEY---GSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFI 1549
            :..|.|:   .:||...::.|.:||..|||.|.:.:|:|.:.||||.||:..:.||:.|||||..
  Fly  1397 DRPIAEWLGKQNPSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKF 1461

  Fly  1550 LSISPK--NLGFEQSPFKLTPEFVEVMGG--TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIM 1610
            |..:..  |...:::||.||.:...|:.|  ..|..:..|..|........||:.|.:::.:..|
  Fly  1462 LGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHM 1526

  Fly  1611 RSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGILX 1675
             :.|.:|...   |..||.:|:....:.:..|......:::|.||||..|:    :.::.:.:..
  Fly  1527 -ATAGMPGVN---SNAVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQ----FNFFLHNLAQ 1583

  Fly  1676 ERF 1678
            .||
  Fly  1584 MRF 1586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	82/297 (28%)
Pi3K68D	NP_524028.2	PHA03247	<56..294	CDD:223021	47/239 (20%)
		PI3K_rbd	561..669	CDD:197540	17/111 (15%)
		C2A_PI3K_class_II	844..1021	CDD:175979	38/219 (17%)
		PI3Ka_II	1038..1202	CDD:238441	28/176 (16%)
		PI3Kc_II	1235..1583	CDD:270710	101/398 (25%)
		PX_PI3K_C2_68D	1611..1721	CDD:132794
		C2B_PI3K_class_II	1751..1871	CDD:176027