DRSC/TRiP Functional Genomics Resources

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Protein Alignment shu and FKBP6

DIOPT Version :10

Sequence 1:NP_611837.1 Gene:shu / 45360 FlyBaseID:FBgn0003401 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_003593.3 Gene:FKBP6 / 8468 HGNCID:3722 Length:327 Species:Homo sapiens


Alignment Length:315 Identity:93/315 - (29%)
Similarity:151/315 - (47%) Gaps:18/315 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 DVDGEELRSPWTYSFDELRALMSEI--DENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETA 119
            |..|:.|       ::.|...|.:|  |..:.|.:.|.|..|  .|...|.|.|:||||.|....
Human    15 DAPGQSL-------YERLSQRMLDISGDRGVLKDVIREGAGD--LVAPDASVLVKYSGYLEHMDR 70

  Fly   120 PFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALF 184
            ||||:..|.:..:.:.|:...:.|:|:.:.|||..|.|.|:......:|.|||||.|.|....||
Human    71 PFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLF 135

  Fly   185 KVEVIDYSLIGDAKGIDAIPQEDRDKFCV--VYPKAVDLHLHGKDSVKLGRYQSAATAFERAVSS 247
            ::|::|:....::....|:..|.:|:|.:  |...|......|....:..|:..|...::||:..
Human   136 EIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLL 200

  Fly   248 LNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRA-CIMMKALRHLTMGNPSCKALFQEGR 311
            |.. |.|..||:.........:..||...|.|:::|..| |...:|   |.:...:.||||:.|:
Human   201 LRR-RSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQA---LIIDQKNAKALFRCGQ 261

  Fly   312 ALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFS 366
            |...|.||..||:..::||.:||.|.:|::|:..:......|.:..:::|.|.|:
Human   262 ACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFA 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shuNP_611837.1 FKBP_C 96..189 CDD:459735 35/92 (38%)
TPR repeat 218..257 CDD:276809 9/38 (24%)
TPR 230..>389 CDD:440225 40/138 (29%)
TPR repeat 262..295 CDD:276809 8/33 (24%)
TPR repeat 304..329 CDD:276809 11/24 (46%)
FKBP6NP_003593.3 FKBP_C 51..140 CDD:459735 34/88 (39%)
TPR 1 171..204 7/33 (21%)
TPR 2 219..252 9/35 (26%)
TPR 221..>302 CDD:440225 27/83 (33%)
TPR repeat 221..247 CDD:276809 8/28 (29%)
TPR repeat 252..282 CDD:276809 13/29 (45%)
TPR 3 253..286 15/32 (47%)

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