Protein Alignment shu and FKBP8

DIOPT Version :10

• Sequence 1: NP_611837.1
• Gene: shu / 45360
• FlyBaseID: FBgn0003401
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_036313.3
• Gene: FKBP8 / 23770
• HGNCID: 3724
• Length: 413
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 81/376 - (21%)
• Similarity: 137/376 - (36%)
• Gaps: 57/376 - (15%)

  Fly     3 ENFEPYTPQLLKNPLSYSDLVKKGVEFEVDNSQQNHARDLGLDSDSDSDYEDALDVDGEELRSPW 67
            |..||..|.....|......|..|||......::....:...|.......||......||...|.
Human     6 EPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPG 70

  Fly    68 TYSFDELRALMSE-------------IDENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETA 119
            ..:.:.|.|:..|             :...:.::.|........:.|.|.:|          .|.
Human    71 ALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQV----------VTV 125

  Fly   120 PFDSSLLRGSK------FVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGC-PPRIK 177
            ...:||..|::      .||..|...|::.|:::|..|...|.|......|..:|..|. .|.|.
Human   126 HLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPYIP 190

  Fly   178 PKADALFKVEV---IDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAAT 239
            |.|....:|.:   :|...:....|.:.:...:|.:.|            |....:...:..||.
Human   191 PHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKREC------------GNAHYQRADFVLAAN 243

  Fly   240 AFERAVSSLNYCRMAN--DEEERKQTELLTTLNQNLMIVYNKMNKPK---RACIMMKALRHLTMG 299
            :::.|:.::......:  .|||.:..:|......||.....|::..:   |:|.::  |.|
Human   244 SYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLV--LEH---- 302

  Fly   300 NP-SCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKR 349
            .| :.||||::|:.||..|||:.|......|...:|:||.|..|:..:.|:
Human   303 QPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKK 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shu	NP_611837.1	FKBP_C	96..189	CDD:459735	24/102 (24%)
		TPR repeat	218..257	CDD:276809	4/40 (10%)
		TPR	230..>389	CDD:440225	33/126 (26%)
		TPR repeat	262..295	CDD:276809	7/35 (20%)
		TPR repeat	304..329	CDD:276809	11/24 (46%)
FKBP8	NP_036313.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		14/61 (23%)
		FKBP_C	113..202	CDD:459735	24/98 (24%)
		TPR	220..>347	CDD:440225	34/144 (24%)
		TPR 1	222..255		6/44 (14%)
		TPR repeat	231..267	CDD:276809	6/35 (17%)
		TPR repeat	272..302	CDD:276809	6/31 (19%)
		TPR 2	273..306		8/38 (21%)
		TPR 3	307..340		13/32 (41%)
		TPR repeat	307..335	CDD:276809	12/27 (44%)
		TPR repeat	341..369	CDD:276809	4/13 (31%)