Protein Alignment pk and prickle1b

DIOPT Version :10

• Sequence 1: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Sequence 2: NP_001025269.1
• Gene: prickle1b / 556148
• ZFINID: ZDB-GENE-030131-2152
• Length: 872
• Species: Danio rerio
• Alignment Length: 944
• Identity: 338/944 - (35%)
• Similarity: 453/944 - (47%)
• Gaps: 209/944 - (22%)

  Fly   487 PSPPSLLHHPAGGTSSASAHAPFLGGPHMD--------MQRQSHSDDDSGCALEEYTWVPPGLRP 543
            |.|.||        .:.|...|....|.||        .||.|.||||||||||||||||||||.
Zfish     7 PHPMSL--------ETTSGIWPITRAPDMDSRGAKAFGFQRSSTSDDDSGCALEEYTWVPPGLRA 63

  Fly   544 DQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRLFSTQRKRD 608
            :||::|||.:|::||||||||||::|:||||:||||||||:|||.||:||||:||.:||.|||::
Zfish    64 EQVQIYFSCLPEEKVPYVNSPGEKHRIRQLLYQLPPHDNEIRYCQSLSDEERRELHMFSMQRKKE 128

  Fly   609 ALGRGNVRQLMSA--RPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCRELLVDLIYFHR 671
            |||||..:.|..|  ..|:.|.:.|:.|::||||:|.||...||||||.|..|.|||||||||:.
Zfish   129 ALGRGTPKLLPRALQHNCEHCKENINGGEMAVFASRAGPGPCWHPACFTCYTCHELLVDLIYFYH 193

  Fly   672 DGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECDKQLGGQRYIMREGKPY 736
            :|.::|||||||.||||||||||||.||||||||||.|||.||:|.||:..||||||||::|:|:
Zfish   194 NGNIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFSCFECETILGGQRYIMKDGRPF 258

  Fly   737 CLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCNTCRCSLLGRAFLPRRGAIYCS 801
            |..||::::||||:.|||.||||..||:::|.||||||:||.|..|:.||||..|||:.|.||||
Zfish   259 CCGCFESLYAEYCEACGENIGVDHAQMTYEGVHWHATDKCFCCAQCKTSLLGCPFLPKDGRIYCS 323

  Fly   802 IACSKGEPPTPSDSSGTGMYTTPTPPTQR-VRPHPQAPLPARIPSSHASSSPPMSPQQQQQHQAT 865
            ..||.||....||||.:...:..:..::| :|             ...||.|....||.:.:.||
Zfish   324 KDCSLGEDVQASDSSDSAFQSARSRESRRSIR-------------MGKSSRPTEQCQQTKLYSAT 375

  Fly   866 -----------------------FNQAMYQMQSQQMEAAGGLVD---QSKSYA------------ 892
                                   |.:..|..:..:.||....|:   :.:.|.
Zfish   376 DYRTSSLCGDNTETMCHQLERINFTEDNYWRERDEQEAPEDSVEDWAEHEDYMTQLLLKFGDRGV 440

  Fly   893 --ASDSDAG---VVKDLEHGG-----HMGGGDL------TDFSGGRASSTSQNLSPLNSPGDFQP 941
              |.||.|.   :|||.|...     .|.|.:|      ||....::.....:.:..:.||   |
Zfish   441 IHAEDSRAAEPWMVKDTETNRTKPEIKMSGHNLASKKHHTDMYWAQSQDGLGDSAYGSHPG---P 502

  Fly   942 HFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYH-----LQRQLLENPHTA--SMPELAGKL 999
            ....|..||:.|        ...:...|| :|...|.     :..:|.:..|..  ||..||
Zfish   503 ASARKIQELEMD--------QGTVPGFWS-EPRQWYEDSLECITSELRKADHNIGDSMDSLA--- 555

  Fly  1000 VAPPAHMQHLSQLHAVS---SHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGS 1061
                     ||.:...|   ..:.:|..|:  |........||.|  ..|:|...|     |..|
Zfish   556 ---------LSNITGASVDGDSKDRQTIYS--LQNMKDQEREIEE--CDNISNVGT-----LNSS 602

  Fly  1062 PTHSAGD--RSLNTPMSTQSA-----------SHAPPHPVSILSGASSSSPMS----------GE 1103
            ..|.:.:  ||||:.:..:..           ...||:     .||...||::          .:
Zfish   603 MLHRSANSLRSLNSELGHEETLGQGAREDDEEDRIPPY-----FGAEPPSPLNLPVLRRTKSQSQ 662

  Fly  1104 P-AKKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRD----------KDKEGGGRHGHGHS 1157
            | ::.:.|:|.   |.:.....|...|.......||.|.|.          .::....||.|
Zfish   663 PQSRSQQVKFS---DDVLEKGYYGALGLRQPPMSERTRRRTFHIEEEAAAAAERRPANRHHH--- 721

  Fly  1158 SRRRRRRKSSSSSSHHRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVH-ESPSRQQ 1221
             :||..||:.|.::.|..       |..|...:...|.:||:...|.:.:...:..| :.|.||.
Zfish   722 -KRRHSRKTRSENALHLP-------SKNRGKLHVVPQVISSNMPEPRNGILLNHSAHSQHPYRQT 778

  Fly  1222 ----------REREREREREESEESDVCSTCSSSSSSSED--YMMMYQLPQRR----HY----GG 1266
                      |..:.:...::.||.|.|||||||||.||:  :.:...:|:.|    ||    ..
Zfish   779 TSDFPQQGMVRLDQFQDFCDDDEEDDWCSTCSSSSSESEEEGFFLGQPIPKPRSQSFHYYTEDYP 843

  Fly  1267 VRV-SYVPNDALAYDRKRKPSELGGDKDKNCIIS 1299
            .|| :..|........|:|     |.|.||||||
Zfish   844 TRVTALTPPFGSRTKLKKK-----GHKGKNCIIS 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	70/94 (74%)
		LIM1_Prickle	624..682	CDD:188799	33/57 (58%)
		LIM2_Prickle	687..742	CDD:188802	40/54 (74%)
		LIM3_Prickle	747..805	CDD:188804	35/57 (61%)
prickle1b	NP_001025269.1	PET_Prickle	43..139	CDD:193602	70/95 (74%)
		LIM1_Prickle	146..204	CDD:188799	33/57 (58%)
		LIM2_Prickle	209..264	CDD:188802	40/54 (74%)
		LIM3_Prickle	269..327	CDD:188804	35/57 (61%)