DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment net and Srebf2

DIOPT Version :9

Sequence 1:	NP_001259789.1	Gene:	net / 45339	FlyBaseID:	FBgn0002931	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_150087.1	Gene:	Srebf2 / 20788	MGIID:	107585	Length:	1130	Species:	Mus musculus

Alignment Length:	343	Identity:	65/343 - (18%)
Similarity:	109/343 - (31%)	Gaps:	77/343 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNDRDAGFCSASSESEGGDDLVVEHARSGSP--DIRPKGTDSADSKPIALVRNKRKSSEPFKVVG 91
            ||.......|....:.|..|..|:.:.|..|  ...|..     :.|.|.....:.|..|.:...
Mouse    59 SNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTFSPSA-----ASPQAPALQVKVSPTPPRATP 118

  Fly    92 LTTPNSKSMPGPPSSASMN--------ATGP----LKKRIRYTSSADSAVVLTPPA---IDSPPP 141
            :..|..:..|.||:.....        :|.|    :::.:.|.::|.|..||.|..   :.||..
Mouse   119 VLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSPQV 183

  Fly   142 NSCIPSTLRLQ------HEIMPNPAHIYVRHPGVTTLHRSLAAHPEQL-----------EPLALV 189
            .   |.|::.|      ..::...|:..::.....|:....|...:|:           :.|.|.
Mouse   184 Q---PVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLT 245

  Fly   190 TTKKQ----CVDQAGPKIEAFSA----------LLIGKQPSAKKTLKERTQKESTSSSFLEASLS 240
            |.|..    ......|.:.|.:|          .|:|...:...|:.....:|......:...:.
Mouse   246 TLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVK 310

  Fly   241 DEDLNKTGLAPISRPHQHQRNYKNMTRERRIEANARERTRVHTISAAYETLRQAVPAYASTQKLS 305
            ..|..|.|                   |||...|..|:....:|:.....|:..|  ..:..|:.
Mouse   311 QLDPPKEG-------------------ERRTTHNIIEKRYRSSINDKIIELKDLV--MGTDAKMH 354

  Fly   306 KLSVLRVACSYILTLSRM 323
            |..|||.|..||..|.::
Mouse   355 KSGVLRKAIDYIKYLQQV 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
net	NP_001259789.1	HLH	269..320	CDD:278439	15/50 (30%)
Srebf2	NP_150087.1	Transcriptional activation (acidic). /evidence=ECO:0000250\|UniProtKB:P36956	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..133		17/78 (22%)
		Interaction with LMNA. /evidence=ECO:0000269\|PubMed:11929849	226..480		32/168 (19%)
		HLH	320..370	CDD:278439	15/51 (29%)
		Leucine-zipper	369..390		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910