DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment net and MESP2

DIOPT Version :9

Sequence 1:	NP_001259789.1	Gene:	net / 45339	FlyBaseID:	FBgn0002931	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001035047.1	Gene:	MESP2 / 145873	HGNCID:	29659	Length:	397	Species:	Homo sapiens

Alignment Length:	191	Identity:	47/191 - (24%)
Similarity:	69/191 - (36%)	Gaps:	57/191 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SPPPNSCIPSTLRLQHEIMPNPAH-IYVRHPGVTTLHRSLAAHPEQLEPLALVTTKKQCVDQAGP 201
            ||||.|.      |.|:      | |:.:..|       .|.|.:...|.:...:...|......
Human     4 SPPPQSL------LGHD------HWIFAQGWG-------WAGHWDSTSPASSSDSSGSCPCDGAR 49

  Fly   202 KIEAFSALLIGKQPSAKKTLKERTQKESTSSSFLEASLSDEDLNKTGLAPISRPHQHQRNYKNMT 266
            .:         .||          |..|.||...||:.:.....:||      |...||.
Human    50 GL---------PQP----------QPPSCSSRAAEAAATTPRRARTG------PAGGQRQ----- 84

  Fly   267 RERRIEANARERTRVHTISAAYETLRQAVPAYAST--QKLSKLSVLRVACSYILTLSRMAG 325
                 .|:.||:.|:.|::.|...||:.:|...:.  |.|:|:..||:|..||..||.:.|
Human    85 -----SASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLG 140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
net	NP_001259789.1	HLH	269..320	CDD:278439	17/52 (33%)
MESP2	NP_001035047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..92		18/98 (18%)
		HLH	82..135	CDD:278439	19/62 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..208
		13 X 2 AA tandem repeats of G-Q	179..204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..295
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910