DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lin and Lins1

DIOPT Version :10

Sequence 1:NP_524815.1 Gene:lin / 45325 FlyBaseID:FBgn0002552 Length:858 Species:Drosophila melanogaster
Sequence 2:NP_001387157.1 Gene:Lins1 / 308704 RGDID:1308792 Length:742 Species:Rattus norvegicus


Alignment Length:694 Identity:130/694 - (18%)
Similarity:241/694 - (34%) Gaps:222/694 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 YLREWPTNKLLQFLSNL--QLLFDIYLKQNAKGFI------------CTR-------IMDVCDAL 257
            |:.|.....:.:.|.:|  ::|....|:.:..|:|            ||.       :.||.|.:
  Rat     3 YIVEIKMESVQEILDHLYRKVLLGATLEDDLHGYIVYLNPDLSEQAVCTASSVARSDVRDVLDGM 67

  Fly   258 IRNDHKLIDEIIVLAGYENSYVQFLAGRVLAAFLVIAKQELNDEWLQKIVD------QLFNFEQL 316
             ...|.:   .|:....|.|..|...||  |..:.:.:..|.|..|.:::.      ....:.:|
  Rat    68 -AGQHGV---SILPEAQECSRRQLQTGR--AWEVTLLQLTLIDMVLSRVLSAETESRAKAGYREL 126

  Fly   317 DQAAVQKIHFSLDIIKRIVEWKDMEIHPLDDDWMASANSTSAASSVVPLSTEASVSYMHFPVQEQ 381
            .:..:|.|.....:| |:::                 ||....|.   |:.:...|.::|.::|:
  Rat   127 TEVLLQSIELDSKLI-RVLQ-----------------NSDKLLSY---LAAKCLASLLYFQLREK 170

  Fly   382 PLATNYFALQFREDTEGERETGQEAPDNRDRHRRHFGEDMNVAYEPHPAPQSTTMPSGCHVVTLT 446
            .:.:|.:.                                                :.|......
  Rat   171 KMLSNSWV------------------------------------------------TFCQKHLSD 187

  Fly   447 DSESFDTTHLKCITIQKLEHKWPTLVKNMSELMAPTHQDAAE----------------------- 488
            .||..:..|..|:           |...|.|:....|...||                       
  Rat   188 SSEGGEAVHCLCV-----------LAAVMKEIFKDAHSQRAESLKQLLTPFDNTFEAFYNSLFSQ 241

  Fly   489 ------------HCVLNFLQLWENIISVKANLSID--ETRPYYAQLDKFELL-------LSHSLS 532
                        ..::.||:|.|.:::.:.:|.:.  ..|..:.:....::|       :...|.
  Rat   242 HFGNFKNPSNIISSLMCFLELLELLVASRIHLKLHLRSQRMLFLKPHALDILAWPIPAFIKRKLV 306

  Fly   533 CTVYKQMLCLFNEALCYGS--TLALQD-MLPEETCKLAHQIV--CHVRGFRILESLPRRQPDNMV 592
            ..:.|.:||...|..|..|  ||...| :|..:...||..::  .|:..::.| ::|        
  Rat   307 ILIKKCLLCKVGEDFCRESVPTLMSPDHLLDSDMLALADALLHAIHLGLWKAL-TVP-------- 362

  Fly   593 SLIGYNGKPMVYANGTITLAHAAQSGDSEEDGAPLDLIEMDKTLLQKMVLLVLKSIAVTVKEIRS 657
                  |||..:            .||..:.|..| ....|...|:...|:.:||:.:..:...|
  Rat   363 ------GKPSCF------------GGDEVQPGCRL-RAGPDHVTLRAASLITVKSLEIKFQNCTS 408

  Fly   658 DSSDSSIDSTDYDAFQDMMLIERSIRDVLSKLETFIKQTLEFHPECHFSKILIHLFDDQDDHLIE 722
             :::...|            :::.:.:.|:.|:..::.:|:.|..|.:   |..:|.:|||.::|
  Rat   409 -ATEMKAD------------LQKFLPEFLAFLKPQLQPSLQLHNPCEW---LSRVFIEQDDDMLE 457

  Fly   723 AMVCTLDV----TSGISFRNNAFPELVAML--------NPVYTFLEFLKMTSNSSDLLLDLLVSN 775
            |...:|.:    |.......:..||..|.:        ||...||.|||..:..|.:|||.|:|:
  Rat   458 AAKASLSIYLHLTREWDTSTSLTPEKEAWIHSTHGHGYNPHCIFLFFLKNIAFDSTVLLDFLISS 522

  Fly   776 ETCFLLYLLRLLKYIRMNWTMFVHSCHTFGMGSAMLDEAMGVLI 819
            |||||.|.::.||.::.:|..|:.:|..|    |.::...||.:
  Rat   523 ETCFLEYFVKYLKLLQKDWGHFLSTCQFF----AAMESQCGVSV 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
linNP_524815.1 LINES_N 441..801 CDD:464266 87/420 (21%)
LINES_C 814..850 CDD:464267 2/6 (33%)
Lins1NP_001387157.1 LINES_N 201..548 CDD:464266 83/390 (21%)
LINES_C 701..737 CDD:464267
Blue background indicates that the domain is not in the aligned region.

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