Protein Alignment: Tom40 and TOMM40

• Sequence 1: NP_001259313.1
• Gene: Tom40
• FlyBaseID: FBgn0016041
• Length: 344
• Species: Drosophila melanogaster
• Sequence 2: NP_001122388.1
• Gene: TOMM40
• HGNCID: 18001
• Length: 361
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 189/366 (52%)
• Similarity: 239/366 (65%)
• Gaps: 25/366 (7%)

  Fly     1 MGNVLAASS---GAPGSGASNLGLGLQEPAP------LPSNSGSL---TESSSSAEGLDSLA--- 50
            |||||||||   |.|...|..| :||..|.|      ||...|||   |.:|.|:|.....|
Human     1 MGNVLAASSPPAGPPPPPAPAL-VGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGAATAS 64

  Fly    51 ---AAKDAA---LENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGY 109
               ||:|.|   |.||||.||.|:|||::..|..||.|:.:||||||||||:||:.:|.:..|.|
Human    65 ASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNY 129

  Fly   110 RFGATYVGTKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDY 174
            .||.||||||:.|||||||||:||:|.:|:|||.||||....||.|.|.|.|:||.|..|:..:|
Human   130 HFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEY 194

  Fly   175 RGSDYTLSLTVANPSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTA 239
            ||||:|.::|:.||.:...||::|..||||:||.||||.||.|.   ..||.:..:||:.|:||.
Human   195 RGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYH---RRPGEEGTVMSLAGKYTL 256

  Fly   240 GSSVWSGTLGQSGLHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSN 304
            .:.:.:.||||:|:|..||.|||||||:|.|.|.|.|||::..:..||:|||||||:|:|.:|||
Human   257 NNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSN 321

  Fly   305 WQIFGVLEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMIG 344
            |.:...|||:|.|||.||||...:||.||.|:.|.||.||
Human   322 WIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTIG 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	157/287 (55%)
TOMM40	NP_001122388.1	Porin3_Tom40	77..361	CDD:132766	157/287 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C260512797
eggNOG	1	0.900				E1_KOG3296
Hieranoid	1	1.000
Homologene	1	1.000				H101105
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2276
Isobase	1	0.950		0	Normalized mean entropy	S1946
OMA	1	1.010
OrthoDB	1	1.010				D1346842at2759
OrthoFinder	1	1.000				FOG0001097
OrthoInspector	1	1.000				T130062
orthoMCL	1	0.900				OOG5_128889
Panther	1	1.100			LDO	PTHR10802
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R2855
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	15	14.750