Protein Alignment Hsp70Ba and HSPA2

DIOPT Version :10

• Sequence 1: NP_731716.1
• Gene: Hsp70Ba / 44921
• FlyBaseID: FBgn0013277
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 643
• Identity: 481/643 - (74%)
• Similarity: 549/643 - (85%)
• Gaps: 12/643 - (1%)

  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFD 66
            ||||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||.||:||
Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    67 AKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||||::|..:..|||||||:|||:|||||:.||||||:|.|.||||||||||||||.||||
Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN--LKGERNVLI 194
            ||..:..|||||||||||||||||||||.|.|||||||||||||||:||||||.  ..||:||||
Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALR 259
            |||||||||||||||::| :|||:||||||||||||||||:|:|||||||||:|||:..|.||:|
Human   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264

  Fly   260 RLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKM 324
            |||||.|||||||||||:|:||||:|:||.||||.::|||||||.|||||.||:||||||.|||:
Human   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   325 DKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDV 389
            |||||.:||||||||||||:|.|||:||:||.||.|||||||||||||||||||.||:|..:||:
Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   390 LLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNAL 454
            ||:||.||||||||||||||.||:||..||.|||:||:||||||..|.:||||||||||||||.|
Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459

  Fly   455 GTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNE 519
            |.|||:|||||||||||||||||:||||||||:|.:.||||...|||.|||||||:.:|||||.|
Human   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524

  Fly   520 AEKYADEDEKHRQRITSRNALESYVYNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTT 583
            ||:|..|||.:|.|:.::||||||.||:||:|| :...||:.|.|||.:||||.|.|.|||.|..
Human   525 AERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589

  Fly   584 AEKEEFDHKMEELARHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641
            |||:|::||.:||.|.|:||::|::|      ||||...|  .||.|...|||:||||
Human   590 AEKDEYEHKQKELERVCNPIISKLYQ------GGPGGGSG--GGGSGASGGPTIEEVD 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	479/641 (75%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	465/609 (76%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		312/383 (81%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		89/114 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		14/33 (42%)