Protein Alignment Hsp70Ba and HSPA12A

DIOPT Version :10

• Sequence 1: NP_731716.1
• Gene: Hsp70Ba / 44921
• FlyBaseID: FBgn0013277
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001317093.1
• Gene: HSPA12A / 259217
• HGNCID: 19022
• Length: 692
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 137/663 - (20%)
• Similarity: 226/663 - (34%)
• Gaps: 216/663 - (32%)

  Fly     4 IGIDLGTTYS-----------CVGVYQHGKVEIIANDQG--NRTTPSYVAFTDSERLIGDPAKNQ 55
            :.:|.|||.|           |:.|.:..:    ..|.|  |:.||:.:..|...:.      :.
Human    76 VAVDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKF------HS 130

  Fly    56 VAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGE-----------SK 109
            .....|:...|.         ||   .:.|.|.:.     .|.|:.:...|:           .|
Human   131 FGYAARDFYHDL---------DP---NEAKQWLYL-----EKFKMKLHTTGDLTMDTDLTAANGK 178

  Fly   110 RFAPEEISSMVLTKMKETAEAYLGESI------TDA--VITVPAYFNDSQRQATKDAGHIAGL-- 164
            :....||.:..|...||.|...|.:..      :|.  ||||||.:....:|..:.|.:.|||
Human   179 KVKALEIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLAS 243

  Fly   165 ----NVLRIINEPTAAAL--------------------AYG------------------------ 181
                ..|.|..||.||::                    .|.
Human   244 PENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRT 308

  Fly   182 -LDKNLKGE--------RNVLIFDLGGGTFDVSI--LTIDEGSLFEVRSTAGDTH--LGGE-DFD 232
             |.:|:.||        ...::.|.||||.|:::  :.:.||.|.|:....|..:  ||.: :|:
Human   309 FLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFE 373

  Fly   233 NRLVTHLAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKV-- 295
            ..|.....|:|..::|   ...|.|...|..|.|..||..:......:.|...|...|:|.|.
Human   374 KLLYKIFGEDFIEQFK---IKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRG 435

  Fly   296 ---------SRARFEELCAD------------LFRNTLQPVEKALND--AKMDKGQIHDIVLVGG 337
                     |...|.:..:.            ||:.|:..:.:.|.|  .|.:...:..:.||||
Human   436 HSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGG 500

  Fly   338 STRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSG-DQSGKIQDVLLVDVAPLSLGI 401
            ....|.:|..:|..| |....:.|..|..:   ..::.|:|.| |.:     |:.|..:||:.|:
Human   501 FAEAPLLQQAVQAAF-GDQCRIIIPQDVGL---TILKGAVLFGLDPA-----VIKVRRSPLTYGV 556

  Fly   402 ETAGGVMTKLIE--------------RNCR------IPCKQT--------KTFSTYSDNQPGVSI 438
                ||:.:.:|              |.|.      |...|:        ::::....:|..:.|
Human   557 ----GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVI 617

  Fly   439 QVYEGERAMTKDN---------NALGT--FDLSGIP----PAPRGVPQIEVTFDLDANGILNVSA 488
            .:|..|.    ||         ...||  .||:|..    ||.|.:..:....|.:    :..:|
Human   618 NIYSSEH----DNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREIQTLMQFGDTE----IKATA 674

  Fly   489 KEMSTGKAKNITI 501
            .:::|.|:..:.|
Human   675 IDIATSKSVKVGI 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	137/663 (21%)
HSPA12A	NP_001317093.1	ASKHA_NBD_HSP70_HSPA12A	74..540	CDD:466841	104/497 (21%)