Protein Alignment mys and ITGB5

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_002204.2
• Gene: ITGB5 / 3693
• HGNCID: 6160
• Length: 799
• Species: Homo sapiens
• Alignment Length: 842
• Identity: 316/842 - (37%)
• Similarity: 449/842 - (53%)
• Gaps: 85/842 - (10%)

  Fly     9 CQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTE-GCAWCMQPDFKGQSRCYQN 72
            |.|.|  .|:|..:||..          :.|..|...|..|:... .||||.:.|| |..|   :
Human    11 CLLGL--CALLPRLAGLN----------ICTSGSATSCEECLLIHPKCAWCSKEDF-GSPR---S 59

  Fly    73 TSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSS 137
            .:|.|                      ..:|.|...|.|..:...:||.:...|     ...||.
Human    60 ITSRC----------------------DLRANLVKNGCGGEIESPASSFHVLRS-----LPLSSK 97

  Fly   138 GSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKA 202
            ||.|| |:      :::|:.||.:.:.||..:|...::...|.|.||||||||||||.||:||..
Human    98 GSGSA-GW------DVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLD 155

  Fly   203 KLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPC------ENCKAPYGYQNH 261
            .:.:||.||:|.|:::|:||.|||||||||.:.|:..|.|:...:||      .||...:|:::.
Human   156 NIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHL 220

  Fly   262 MPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAG 326
            :||.:..:||:.||:...||.|.|||||||||::||..|:.:||||:.|..||||:||...|.|.
Human   221 LPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIAL 285

  Fly   327 DGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVE 391
            ||||||::.|:||:|||:...|||.|...||||::.:.:|:.:|.||:|||||.:...:|:....
Human   286 DGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTA 350

  Fly   392 HIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKD-NATGDVKITYFSSCLSNGPEVQTSKCDN 455
            .|.|::...||.||.|:::|:...|..|.|.||:.. :...|:.:.:.::|..........||:.
Human   351 LIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEG 415

  Fly   456 LKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQAN 520
            ||.|...||...::...||.  |.......:.|||..:.:::.:|..|:|.|    |:|.:..:.
Human   416 LKIGDTASFEVSLEARSCPS--RHTEHVFALRPVGFRDSLEVGVTYNCTCGC----SVGLEPNSA 474

  Fly   521 SCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECH 585
            .|:|.||.:||:|.|...|.|.:|||...:..|.:.|  .|| ::.....|||||.|.|..|.|.
Human   475 RCNGSGTYVCGLCECSPGYLGTRCECQDGENQSVYQN--LCR-EAEGKPLCSGRGDCSCNQCSCF 536

  Fly   586 KRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPP 650
            :  :....|.|..||||||||.||:..||||  ||.|.||.|||..|:.|.||.|.....||. .
Human   537 E--SEFGKIYGPFCECDNFSCARNKGVLCSG--HGECHCGECKCHAGYIGDNCNCSTDISTCR-G 596

  Fly   651 GGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDC 715
            ..|:|||..|.|.||.|:||  :.|.| |..|||||||...|...:|||:|.:..:|:..| ..|
Human   597 RDGQICSERGHCLCGQCQCT--EPGAF-GEMCEKCPTCPDACSTKRDCVECLLLHSGKPDN-QTC 657

  Fly   716 ARNCTQFVPVGVEKVEIDETKDEQ---MCKFFDEDDCKFMFKYSE--QGELHVYAQENKECPAKV 775
            ...|...|...|:.:    .||:|   :|.:....||..||.|.|  .|:.::......||....
Human   658 HSLCRDEVITWVDTI----VKDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTP 718

  Fly   776 FMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATST 837
            ..:.|::.|:.:|:|||||:|.:||||.|||||||||:|:.||..|:::...||:|::..||
Human   719 NAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPIST 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	170/467 (36%)
		Integrin_B_tail	692..775	CDD:462325	24/87 (28%)
		Integrin_b_cyt	803..843	CDD:462580	18/35 (51%)
ITGB5	NP_002204.2	INB	35..463	CDD:197563	170/467 (36%)
		I-EGF_1	465..493	CDD:465729	11/31 (35%)
		Integrin_B_tail	635..714	CDD:462325	22/83 (27%)
		Integrin_b_cyt	746..781	CDD:462580	18/35 (51%)