Protein Alignment mys and ITGB2

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000202.3
• Gene: ITGB2 / 3689
• HGNCID: 6155
• Length: 769
• Species: Homo sapiens
• Alignment Length: 854
• Identity: 306/854 - (35%)
• Similarity: 444/854 - (51%)
• Gaps: 115/854 - (13%)

  Fly    11 LALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWCMQPDFKGQS-----RC 69
            |||:.:..|..:.    :|:..|....|       |..||:: .||.||.:.:|.|..     ||
Human     9 LALVGLLSLGCVL----SQECTKFKVSS-------CRECIESGPGCTWCQKLNFTGPGDPDSIRC 62

  Fly    70 YQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
                            .|..|:|                     |.|.::......
Human    63 ----------------DTRPQLL---------------------MRGCAADDIMDP--------- 81

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                :|.|...|:::.|: .|:.||.:.|.||..:.....:::.:|:|||:|||||||||.||.|
Human    82 ----TSLAETQEDHNGGQ-KQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLD 141

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN----CKAPYGYQN 260
            |...:..||..|...:..||.:..:||||||||.::|:|:|.|.||.:||.|    |:.|:.:::
Human   142 DLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRH 206

  Fly   261 HMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYA 325
            .:.|.||:..|..||....:||||||||||.||:||..||..:|||| ...|||||:||.|||:|
Human   207 VLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWR-NVTRLLVFATDDGFHFA 270

  Fly   326 GDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLV 390
            ||||||.::.||||.|||. ...|..|...||||:.|:..|:.:|.|..|||||:..:..||||.
Human   271 GDGKLGAILTPNDGRCHLE-DNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLT 334

  Fly   391 EHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLSNGPEVQT---S 451
            |.|..|:..:|..||||||.|:|..|.|:||.|.:..||..| :|:||.|.| |||...:.   .
Human   335 EIIPKSAVGELSEDSSNVVHLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFC-SNGVTHRNQPRG 398

  Fly   452 KCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQ 516
            .||.::....::|..::...:|.::     |:..|..:|..:::.:|:...|.|.|.:...
Human   399 DCDGVQINVPITFQVKVTATECIQE-----QSFVIRALGFTDIVTVQVLPQCECRCRDQSR---- 454

  Fly   517 VQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGA 581
             ..:.|.|.|...||||.||..|.|..|||.....:|: ..:.|||.|:.|.. |||.|.||||.
Human   455 -DRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQ-ELEGSCRKDNNSII-CSGLGDCVCGQ 516

  Fly   582 CECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDT 646
            |.||....|.::|.|::||||..:|||...|:|.||..|.|.||:|:|.||:.||.|.|:.:.:.
Human   517 CLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEG 581

  Fly   647 CMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRH---CEKCPTCSGRCQELKDCVQCQMYKTGE 708
            |:.|...| |||.|.|.|.||:|       .||..   |::||.|...|.:...|.:|..::.|.
Human   582 CLNPRRVE-CSGRGRCRCNVCEC-------HSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGP 638

  Fly   709 LKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELH---VYAQENKE 770
            .      .:||:...| |:: :..:..|. :.||..|.:.|...:...:|..:.   :|..|::|
Human   639 F------GKNCSAACP-GLQ-LSNNPVKG-RTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRE 694

  Fly   771 CPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQAT 835
            |.|...:..||.|.:|.|||:|:.:|::||.|..:.|.||:.|||||::.::|: .:||::|.||
Human   695 CVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWN-NDNPLFKSAT 758

  Fly   836 STFKNPMYA 844
            :|..||.:|
Human   759 TTVMNPKFA 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	173/473 (37%)
		Integrin_B_tail	692..775	CDD:462325	19/85 (22%)
		Integrin_b_cyt	803..843	CDD:462580	17/39 (44%)
ITGB2	NP_000202.3	INB	32..447	CDD:197563	174/480 (36%)
		Cell attachment site. /evidence=ECO:0000255	397..399		0/1 (0%)
		I-EGF_1	<457..476	CDD:465729	9/18 (50%)
		Integrin_B_tail	622..699	CDD:462325	19/85 (22%)
		Integrin_b_cyt	727..766	CDD:462580	17/39 (44%)