Protein Alignment mys and ITGB1

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_391988.1
• Gene: ITGB1 / 3688
• HGNCID: 6153
• Length: 801
• Species: Homo sapiens
• Alignment Length: 858
• Identity: 360/858 - (41%)
• Similarity: 480/858 - (55%)
• Gaps: 96/858 - (11%)

  Fly    15 MIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWC-----MQPDFKGQSRCYQNT 73
            :|:.:..:..|||..:..|       |:.:.|..|||. ..|.||     :|......:|| .:.
Human    11 LISSVCCVFAQTDENRCLK-------ANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARC-DDL 67

  Fly    74 SSL----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
            .:|    ||.:...:|...:.|..|..:||:.|        |:|
Human    68 EALKKKGCPPDDIENPRGSKDIKKNKNVTNRSK--------GTA--------------------- 103

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                       |:....:|.|||||.:.|.||..|.....:.:.:||.||:|||||||||.||:|
Human   104 -----------EKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKD 157

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPC---ENCKAPYGYQNH 261
            |...:.:||..|...|:|||::|.:||||||:|.:|||:||.|.||.:||   :||.:|:.|:|.
Human   158 DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNV 222

  Fly   262 MPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAG 326
            :.|.|..|.|:..|....:|||||:||||||||||...|.|.|||| ...||||||||||||:||
Human   223 LSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWR-NVTRLLVFSTDAGFHFAG 286

  Fly   327 DGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVE 391
            ||||||::.||||:|||. ...||.|...|||||:.:.||:.:|.|..|||||.....||::|..
Human   287 DGKLGGIVLPNDGQCHLE-NNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKN 350

  Fly   392 HIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLS--NGPEVQTSKC 453
            .|..|:...|..:||||::|:.:.|..:||.|.:::....: |.|:|.|.|.:  ||......||
Human   351 LIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKC 415

  Fly   454 DNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQ 518
            .|:..|.:|.|...|...|||:...|   :..|.|:|..|.:::.|..:|.|.|::.|.    .:
Human   416 SNISIGDEVQFEISITSNKCPKKDSD---SFKIRPLGFTEEVEVILQYICECECQSEGI----PE 473

  Fly   519 ANSC-SGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGAC 582
            :..| .|:||..||.|.|::...|..||||..::.|: ..|..||.:::|.. ||..|.||||.|
Human   474 SPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSE-DMDAYCRKENSSEI-CSNNGECVCGQC 536

  Fly   583 ECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTC 647
            .|.||.|..||.|||.||||||:|:|:...:|.|  :|.|:|..|:|.|.:|||.|.|.....||
Human   537 VCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGG--NGVCKCRVCECNPNYTGSACDCSLDTSTC 599

  Fly   648 MPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNG 712
             ....|:||:|.|.|||||||||   ..:|.|:.||.|.||.|.|.|.|:||||:.:..||.|
Human   600 -EASNGQICNGRGICECGVCKCT---DPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKK-- 658

  Fly   713 DDCARNCTQFVPVGVEKVEIDETKDEQM-------CKFFDEDDCKFMFKYSEQG--ELHVYAQEN 768
            |.|.:.|:.|   .:.|||..:...:.:       ||..|.|||.|.|.||..|  |:.|:..||
Human   659 DTCTQECSYF---NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN 720

  Fly   769 KECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQ 833
            .|||....::.||.||:|.|||:|||:||:||||..||||||||:||||:|||||||.||||||.
Human   721 PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTQENPIYKS 785

  Fly   834 ATSTFKNPMYAGK 846
            ..:.||||.|..|
Human   786 PINNFKNPNYGRK 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	188/475 (40%)
		Integrin_B_tail	692..775	CDD:462325	35/91 (38%)
		Integrin_b_cyt	803..843	CDD:462580	29/39 (74%)
ITGB1	NP_391988.1	INB	34..464	CDD:197563	188/475 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..107		11/71 (15%)
		CX3CL1-binding. /evidence=ECO:0000269|PubMed:23125415	207..213		1/5 (20%)
		CX3CL1-binding. /evidence=ECO:0000269|PubMed:24789099	295..314		10/19 (53%)
		Interaction with TMEM182. /evidence=ECO:0000250|UniProtKB:P07228	383..465		24/84 (29%)
		I-EGF_1	466..495	CDD:465729	10/32 (31%)
		Integrin_B_tail	640..727	CDD:462325	35/91 (38%)
		Integrin_b_cyt	755..795	CDD:462580	29/39 (74%)
		Signal for sorting from recycling endosomes, interaction with ACAP1	762..767		3/4 (75%)