Protein Alignment mys and Itgb3

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_714942.1
• Gene: Itgb3 / 29302
• RGDID: 628868
• Length: 787
• Species: Rattus norvegicus
• Alignment Length: 855
• Identity: 327/855 - (38%)
• Similarity: 462/855 - (54%)
• Gaps: 84/855 - (9%)

  Fly     5 RNRR-CQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEG-CAWCMQPDFKGQS 67
            |.|| .||...::| |.|:||....:     :.:.|......|..|:.... ||||........|
  Rat     2 RTRRPGQLWATLLA-LGALAGVVVGE-----SNICTTRGVNSCQQCLAVSPVCAWCSDESLPQNS 60

  Fly    68 -RCYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSS 128
             ||....:.|   |..|....|::..|||....|:::       |.|.||
  Rat    61 PRCNLKKNLLKDKCSPESIEFPVSEAQILEALPLSSK-------GSGDSA--------------- 103

  Fly   129 SSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDL 193
                                   :|.|:.||.:.|.||.::.....:...|.|.||||:||||||
  Rat   104 -----------------------QITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDL 145

  Fly   194 SKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYV-STIPKKLEHPC----ENCK 253
            |.||:||.:.:.|||.||:..|:::|:|..:|||:||||.:.||: .:.|:.:::||    ..|.
  Rat   146 SFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMFISPPQAIKNPCYTMKSTCL 210

  Fly   254 APYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFST 318
            ..:||::.:.|.:....|::|||..:||.|.|||||||||||||..|..:||||..|..||||:|
  Rat   211 PMFGYKHVLTLTDQVTRFNDEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT 275

  Fly   319 DAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQL 383
            ||..|.|.||:|.|::.||||.||:.|...|:.||..||||:..:.:|:....||:|||||.:.:
  Rat   276 DAKTHIALDGRLAGIVLPNDGRCHIGPDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVV 340

  Fly   384 SVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMK-DNATGDVKITYFSSCLSNGPE 447
            |:|:...|.|.|::...|.:|||||::|:.:.|.||.|.||:: .:...::.:::.::||:|...
  Rat   341 SLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVI 405

  Fly   448 VQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGS 512
            .....|..||.|..|||:.:.::..||:...   |:..|.|||..:.:.:|:|..|.|.|:   :
  Rat   406 PGLKSCVGLKIGDTVSFSIEAKVRGCPQQKE---QSFTIKPVGFKDSLTVQVTFDCDCDCQ---A 464

  Fly   513 IGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHC 577
            ....:.....:|:||..||:|.||..:.|:.||||..|.......:.|.:.....   ||.||.|
  Rat   465 FAQPLSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEGQPI---CSQRGEC 526

  Fly   578 VCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQE 642
            :||.|.||.  :....|:||:||||:|||.|.:.::|||  ||.|.||.|.|...|||..|.|..
  Rat   527 LCGQCVCHS--SDFGKITGKYCECDDFSCVRYKGEMCSG--HGQCNCGDCVCDSDWTGYYCNCTT 587

  Fly   643 SNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTG 707
            ..||||.. .|.:|||.|.||||.|.|.  ..|.: |..|||||||...|...||||:|:.:..|
  Rat   588 RTDTCMST-NGLLCSGRGNCECGSCVCV--QPGSY-GDTCEKCPTCPDACSFKKDCVECKKFNRG 648

  Fly   708 ELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSE--QGELHVYAQENKE 770
            :|...::|.|.|..  .:.:.|...|..|:...|.:.:||||...|:|.|  .|...:|..|..|
  Rat   649 KLHEENNCNRFCRD--DIELVKELTDTGKNAVNCTYKNEDDCVVRFQYYEDSSGRAVLYVVEEPE 711

  Fly   771 CPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQAT 835
            ||....:|.:::.|:.||:|:|||.||:||||.|||||:|||:||:||..|||||..||:||:||
  Rat   712 CPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEAT 776

  Fly   836 STFKNPMYAG 845
            |||.|..|.|
  Rat   777 STFTNITYRG 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	168/470 (36%)
		Integrin_B_tail	692..775	CDD:462325	28/84 (33%)
		Integrin_b_cyt	803..843	CDD:462580	27/39 (69%)
Itgb3	NP_714942.1	INB	37..460	CDD:197563	168/470 (36%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05106	202..209		1/6 (17%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000250|UniProtKB:P05106	202..209		1/6 (17%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05106	292..312		10/19 (53%)
		I-EGF_1	462..491	CDD:465729	9/31 (29%)
		Integrin_B_tail	633..716	CDD:462325	28/84 (33%)
		Integrin_b_cyt	744..784	CDD:462580	27/39 (69%)
		LIR. /evidence=ECO:0000250|UniProtKB:P05106	776..782		4/5 (80%)