Protein Alignment mys and Itgb3

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_058060.2
• Gene: Itgb3 / 16416
• MGIID: 96612
• Length: 787
• Species: Mus musculus
• Alignment Length: 853
• Identity: 328/853 - (38%)
• Similarity: 464/853 - (54%)
• Gaps: 97/853 - (11%)

  Fly    12 ALLMIAILA-AIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEG-CAWCMQPDF-KGQSRCYQNT 73
            |||.:..|| .:.|:::         :.|......|..|:.... ||||..... :|..||....
Mouse    12 ALLALGALAGVVVGESN---------ICTTRGVNSCQQCLAVSPVCAWCSDETLSQGSPRCNLKE 67

  Fly    74 SSL---CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQS 135
            :.|   |..|....|::..|||....|                                     |
Mouse    68 NLLKDNCAPESIEFPVSEAQILEARPL-------------------------------------S 95

  Fly   136 SSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDD 200
            |.||.|::        :|.|:.||.:.|.||.::.....:...|.|.||||:|||||||.||:||
Mouse    96 SKGSGSSA--------QITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDD 152

  Fly   201 KAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYV-STIPKKLEHPCEN----CKAPYGYQN 260
            .:.:.|||.||:..|:::|:|..:|||:||||.:.||: .:.|:.:::||.|    |...:||::
Mouse   153 LSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQAIKNPCYNMKNACLPMFGYKH 217

  Fly   261 HMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYA 325
            .:.|.:....|:.|||..:||.|.|||||||||||||..|..:||||..|..||||:|||..|.|
Mouse   218 VLTLTDQVSRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIA 282

  Fly   326 GDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLV 390
            .||:|.|::.||||.||:.....|:.||..||||:..:.:|:....||:|||||.:.:|:|:...
Mouse   283 LDGRLAGIVLPNDGHCHIGTDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVSLYQNYS 347

  Fly   391 EHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMK-DNATGDVKITYFSSCLSNGPEVQTSKCD 454
            |.|.|::...|.:|||||::|:.:.|.||.|.||:: .:...::.:::.::||:|........|.
Mouse   348 ELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCV 412

  Fly   455 NLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCE---NPGSIGYQ 516
            .||.|..|||:.:.::..||::..   |:..|.|||..:.:.:|:|..|.|.|:   .|.|
Mouse   413 GLKIGDTVSFSIEAKVRGCPQEKE---QSFTIKPVGFKDSLTVQVTFDCDCACQAFAQPSS---- 470

  Fly   517 VQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGA 581
            .:.|  :|:||..||:|.||..:.|:.||||..|.......:.|.:.....   ||.||.|:||.
Mouse   471 PRCN--NGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEGQPI---CSQRGECLCGQ 530

  Fly   582 CECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDT 646
            |.||.  :....|:||:||||:|||.|.:.::|||  ||.|.||.|.|...|||..|.|....||
Mouse   531 CVCHS--SDFGKITGKYCECDDFSCVRYKGEMCSG--HGQCNCGDCVCDSDWTGYYCNCTTRTDT 591

  Fly   647 CMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKN 711
            ||.. .|.:|||.|.||||.|.|.  ..|.: |..|||||||...|...|:||:|:.:..|.|..
Mouse   592 CMST-NGLLCSGRGNCECGSCVCV--QPGSY-GDTCEKCPTCPDACSFKKECVECKKFNRGTLHE 652

  Fly   712 GDDCARNCTQFVPVGVEKV-EIDET-KDEQMCKFFDEDDCKFMFKYSE--QGELHVYAQENKECP 772
            .:.|:|.|..    .:|:| |:.:| |:...|.:.:||||...|:|.|  .|...:|..|..|||
Mouse   653 ENTCSRYCRD----DIEQVKELTDTGKNAVNCTYKNEDDCVVRFQYYEDTSGRAVLYVVEEPECP 713

  Fly   773 AKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATST 837
            ....:|.:::.|:.||:|:|||.||:||||.|||||:|||:||:||..|||||..||:||:||||
Mouse   714 KGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATST 778

  Fly   838 FKNPMYAG 845
            |.|..|.|
Mouse   779 FTNITYRG 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	169/470 (36%)
		Integrin_B_tail	692..775	CDD:462325	29/86 (34%)
		Integrin_b_cyt	803..843	CDD:462580	27/39 (69%)
Itgb3	NP_058060.2	INB	37..460	CDD:197563	169/470 (36%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05106	202..209		2/6 (33%)
		Involved in CX3CL1-, NRG1-, FGF1-and IGF1-binding. /evidence=ECO:0000250|UniProtKB:P05106	202..209		2/6 (33%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05106	292..312		9/19 (47%)
		I-EGF_1	462..491	CDD:465729	12/34 (35%)
		Integrin_B_tail	633..716	CDD:462325	29/86 (34%)
		Integrin_b_cyt	744..784	CDD:462580	27/39 (69%)
		LIR. /evidence=ECO:0000250|UniProtKB:P05106	776..782		4/5 (80%)