DRSC/TRiP Functional Genomics Resources

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Protein Alignment sub and KIF23

DIOPT Version :10

Sequence 1:NP_611260.1 Gene:sub / 44870 FlyBaseID:FBgn0003545 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_001354734.1 Gene:KIF23 / 9493 HGNCID:6392 Length:974 Species:Homo sapiens


Alignment Length:641 Identity:176/641 - (27%)
Similarity:279/641 - (43%) Gaps:115/641 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 QSSEATEGASCATSAADSSNVETGPQVFLRLRPV--KDASKAYIVSEEANVLITSCKVDSTSNNV 126
            :|:.|.............:|::....|:.|:||:  .|......|.....|.:.:.:....:.|.
Human     2 KSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGYRLNRNG 66

  Fly   127 NRMEKHFGFTSIFDSTVGQRDIYDTCVGP---KIMEEECVTIMTYGTSGSGKTYTLLGDDVRAGI 188
            :..|..:.|..:|.:...|::::|....|   .::..:...:.|||.:|||||:|:.|.....|:
Human    67 DYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGL 131

  Fly   189 IPRALENIFTIY-----QDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQR 248
            :||.|:.||...     :..||:|...   |...:..:.|| |.|.|.|:.:.:  |..|:..::
Human   132 LPRCLDMIFNSIGSFQAKRYVFKSNDR---NSMDIQCEVDA-LLERQKREAMPN--PKTSSSKRQ 190

  Fly   249 L---------------KQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLL------AIPPK 292
            :               .:.:|.|.::.          |:||::||||..:||||      .|.||
Human   191 VDPEFADMITVQEFCKAEEVDEDSVYG----------VFVSYIEIYNNYIYDLLEEVPFDPIKPK 245

  Fly   293 QDKLGEVPRKNLKIV--------GNKGH-VFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVN 348
            .:.. ..|.:|...|        .:|.| :::.|.|.|.|.|:|||..:...||::...|:|.:|
Human   246 WNSC-STPMRNTDFVPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLN 309

  Fly   349 ANSSRSHCVFTVDILK-----------YNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKN 402
            ..|||||.||.:.:::           ..:..||. |.....|||||||.|.|...|.||:||.|
Human   310 RESSRSHSVFNIKLVQAPLDADGDNVLQEKEQITI-SQLSLVDLAGSERTNRTRAEGNRLREAGN 373

  Fly   403 INTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENL 467
            ||.|||.|..|:|.....|......::||||||||.|.:....|:.|:.|||.|.|..:.|||||
Human   374 INQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEENL 438

  Fly   468 NVLNFASIAKNIIFKEPVIKQHRVSYCG-------------------------FMEFSKMSTCEG 507
            .|:.||.:.:.:....||.|    :.||                         ...|..:.:|| 
Human   439 QVMRFAEVTQEVEVARPVDK----AICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPLPSCE- 498

  Fly   508 GDYTKELEDENVRLQLEIEQLKYDHVLQMQLLEE--KLRRELTATYQEIIQNNKKQYEDECEKKL 570
               ..::.||....:| ||.|:..|.|:..:::|  |......|..|| ..|.....|:..:.||
Human   499 ---ILDINDEQTLPRL-IEALEKRHNLRQMMIDEFNKQSNAFKALLQE-FDNAVLSKENHMQGKL 558

  Fly   571 LIAQRESEFMLSSQR---RRYEEQIEDLKDEIEELKNPASDTDISDDPNESKSPIE 623
                .|.|.|:|.|:   .|.|::.:.|:.:||.|:.  :.|...:|....:..:|
Human   559 ----NEKEKMISGQKLEIERLEKKNKTLEYKIEILEK--TTTIYEEDKRNLQQELE 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
subNP_611260.1 KISc 89..477 CDD:276812 134/438 (31%)
GBP_C <512..603 CDD:293879 27/95 (28%)
coiled coil 576..586 CDD:293879 5/12 (42%)
coiled coil 592..603 CDD:293879 3/10 (30%)
KIF23NP_001354734.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 2/17 (12%)
Nuclear localization signal. /evidence=ECO:0000255 7..11 0/3 (0%)
KISc_KIF23_like 24..448 CDD:276819 134/441 (30%)
PRK03918 <498..>691 CDD:235175 32/123 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..705
Interaction with ARF6. /evidence=ECO:0000269|PubMed:22522702 808..925
MKLP1_Arf_bdg 817..920 CDD:465166
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 912..942
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 955..974
Blue background indicates that the domain is not in the aligned region.

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