Protein Alignment sub and kif20a

DIOPT Version :10

• Sequence 1: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_002936881.1
• Gene: kif20a / 496538
• XenbaseID: XB-GENE-967269
• Length: 910
• Species: Xenopus tropicalis
• Alignment Length: 648
• Identity: 189/648 - (29%)
• Similarity: 312/648 - (48%)
• Gaps: 108/648 - (16%)

  Fly    55 SDTESEYKYQSSEATEGASCATS-AADSSNVETG----PQ-----------VFLRLRPVKDA--- 100
            ||.|....::|:.|..||....: .:|.|.:..|    ||           |::|:||..|.
 Frog    14 SDDEENPVFESTAAECGAGIRKALLSDFSVISPGLGHPPQSMPEESNDKVMVYVRIRPFVDGELE 78

  Fly   101 ---SKAYIVSEEANVLITSCKVDS-----TSNNVNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKI 157
               .:..:..|....|:.....||     |...:.:....|.|:.:|...|.|:..:|..:...:
 Frog    79 KKEDQGCVEVENEETLVLRAPKDSFAMKNTERGLGQSVHKFTFSQLFGPEVDQKQFFDGTMRQVV 143

  Fly   158 ---MEEECVTIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVF 219
               :..:...|.|||.:.||||:|:.|.....||:||::..||...||.:::|..||.::..:::
 Frog   144 KDALNGQNWLIYTYGVTNSGKTFTIQGTSKDRGILPRSIALIFNSAQDRLYKSSDLKPLSNEVMW 208

  Fly   220 LQDDASLKELQIRK-KLLD-------LCP-----------------------DISAHHQRLKQVI 253
            | |...:::.:::| .||.       :.|                       .:|:..|.:.|..
 Frog   209 L-DSKQVRQEELKKVSLLSNLREEELMTPLKRSGNESQVRAGTSVSFDSGIGGLSSTSQFVNQTC 272

  Fly   254 ----------DGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVG 308
                      :...:...:.:.||.:.:|||:.|||||.|||||...|.....   .|..|::..
 Frog   273 SQLEETCSRWNDQEVVSLQEAADVQLSIWVSYYEIYNEFVYDLLDFMPSGPNR---KRTTLRLCE 334

  Fly   309 NK-GHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDIL-KYNRSGIT 371
            :: |:.::|.||.:.|.|:|||.::||:|::..::|||.:|.||||||.:|::.|| ...::.:|
 Frog   335 DRNGNPYVKDLTWINVHSAEEAWKILRVGRKNQSFASTHLNQNSSRSHSIFSIRILHMQGKNDLT 399

  Fly   372 TQ-SSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDA-ASTVQKKKNADIIPYRDS 434
            .: |...|||||||||..:. .||.|||||.||||||..||||:.. ....|:|...:::|:|||
 Frog   400 PKISELSFCDLAGSERCKDQ-RSGDRLKEATNINTSLHTLGRCITVLRQNQQQKLRQNVVPFRDS 463

  Fly   435 KLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHRVSYCGFMEF 499
            |||.:.||...|:.|..|||.:......|:|.|..:.|::||..::...||    :|:.......
 Frog   464 KLTRIFQAYFTGRGKSCMIVNINQCASTYDETLYAMKFSAIASQLVQAPPV----KVNIPSIQSL 524

  Fly   500 SKMST-CEGGDYTKELE-DENVRLQLE---IEQLKYDHVLQM-----QLL----EEKL------R 544
            .|.|| .....||.|.: |||...:.|   |.:...:.:||:     :|:    :|||      |
 Frog   525 IKESTMLANRSYTDEEDADENSDEESEETDIAKFNREELLQVIENMKELIVKERQEKLNMEIQIR 589

  Fly   545 RELTATYQEIIQNNKKQYED--ECEKKLL--IAQRESEFMLSSQRRRYEEQIEDLKDEIEELK 603
            :|:.:...:::|..:||:.:  |.|::||  |.:...|.:..|....|:.::|:..:.||||:
 Frog   590 KEVCSEMMDMMQQQQKQHSESLEDERELLEEIYEGRLENLKESLTNYYKHELEERDERIEELE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_611260.1	KISc	89..477	CDD:276812	139/457 (30%)
		GBP_C	<512..603	CDD:293879	29/113 (26%)
		coiled coil	576..586	CDD:293879	2/9 (22%)
		coiled coil	592..603	CDD:293879	4/10 (40%)
kif20a	XP_002936881.1	KISc_KIF23_like	61..506	CDD:276819	138/449 (31%)
		RBD_KIF20A	<622..657	CDD:409645	8/31 (26%)
		COG2433	<625..>719	CDD:441980	8/28 (29%)