DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sub and ncd

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001287592.1	Gene:	ncd / 43517	FlyBaseID:	FBgn0002924	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	112/440 - (25%)
Similarity:	185/440 - (42%)	Gaps:	103/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 TESEYKYQSSEATEGASCATSAADSS-----------NVETGPQVFLRLRPVKDASK-----AYI 105
            ||...:....:|.|..:|......|:           ::....:||.|:||..::.:     .:.
  Fly   307 TEELLRCNEQQAAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWT 371

  Fly   106 VSEEANVLITSCKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKI---MEEECVTIMT 167
            ..:|:.|.:.|....:.|....::   |.|..:|.....|.||:: .|.|.|   ::...:.|..
  Fly   372 YHDESTVELQSIDAQAKSKMGQQI---FSFDQVFHPLSSQSDIFE-MVSPLIQSALDGYNICIFA 432

  Fly   168 YGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTV--FRSPKLKLINGSIVFLQDDASLKELQ 230
            ||.:|||||||:.|.....|:|||.::.:|    |::  :|:...:
  Fly   433 YGQTGSGKTYTMDGVPESVGVIPRTVDLLF----DSIRGYRNLGWE------------------- 474

  Fly   231 IRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDK 295
                                        :|.||          :|:|||||::||||:...|..:
  Fly   475 ----------------------------YEIKA----------TFLEIYNEVLYDLLSNEQKDME 501

  Fly   296 LGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTV 360
            :...  ||     ||..:::..:|...|........|:...:.....|||:.|..|||||.|..:
  Fly   502 IRMA--KN-----NKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKL 559

  Fly   361 DIL-KYNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKK 424
            ::: ::......:..|....||||||    :..:..|:.|.||||.||..|...:  .:.:||:
  Fly   560 ELIGRHAEKQEISVGSINLVDLAGSE----SPKTSTRMTETKNINRSLSELTNVI--LALLQKQ- 617

  Fly   425 NADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFAS 474
              |.||||:||||.||..:|.|..|..|.:.|:|....::|::..|.||:
  Fly   618 --DHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAA 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	106/397 (27%)
		Kinesin	93..479	CDD:278646	104/393 (26%)
		GBP_C	<512..603	CDD:303769
		coiled coil	576..586	CDD:293879
		coiled coil	592..603	CDD:293879
ncd	NP_001287592.1	KISc_C_terminal	346..672	CDD:276817	106/401 (26%)
ncd	NP_001287592.1	KISc	348..678	CDD:214526	106/399 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437851
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840