Protein Alignment sub and Kif20a

DIOPT Version :10

• Sequence 1: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_001101896.1
• Gene: Kif20a / 361308
• RGDID: 1307695
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 667
• Identity: 189/667 - (28%)
• Similarity: 295/667 - (44%)
• Gaps: 138/667 - (20%)

  Fly    72 ASCATSAADSSNVETGPQVFLRLRPV------KDASKAYIVSEEANVLITSCKVD-----STSNN 125
            ||.....|...:.....:|:||:||.      :...:..:..|....|:.....|     |....
  Rat    48 ASLEDKQAPMEDTAEKMKVYLRIRPFLTSELERQEDQGCVCIENTETLLLQAPKDSFALKSNERG 112

  Fly   126 VNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKIMEEECV-----TIMTYGTSGSGKTYTLLGDDVR 185
            :.:....|.|:.||...|||...::..:  |.|.::.:     .|.|||.:.||||||:.|....
  Rat   113 IGQATHKFTFSQIFGPEVGQVSFFNLTM--KEMVKDVLRGQNWLIYTYGVTNSGKTYTIQGTSKD 175

  Fly   186 AGIIPRALENIFTIYQDTVFRSPKLK-LINGSIVFLQDDASLKELQIRKKLL--------DLCPD 241
            .||:|::|..||...|..:..:|.|| |::..:::| |...:::.:|:|..|        :|...
  Rat   176 VGILPQSLALIFNSLQGQLHPTPDLKPLLSNEVIWL-DSKQIRQEEIKKLSLLIGGLQEEELSTS 239

  Fly   242 IS-------------------AHHQRLKQVIDGDHMFET------------KASTDVSVLVWVSF 275
            :.                   |......|......:.||            ....|:...:|:||
  Rat   240 LKKRVHAESRIGASNSFDSGIAGLSSTSQFTSSSQLDETSQLWAQPDTVPVSVPADIRFSIWISF 304

  Fly   276 VEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNK-GHVFIKGLTSVFVTSSEEALRLLRLGQQR 339
            .||||||:||||..|..|.|     |:.|::..:: |:.::|.|..:.|...|||.:||::|::.
  Rat   305 FEIYNELLYDLLEPPSHQHK-----RQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGRKN 364

  Fly   340 STYASTSVNANSSRSHCVFTVDILKYNRSG--ITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKN 402
            .::|||.:|.:|||||.:|::.||.....|  :...|....||||||||..:. .||.|||||.|
  Rat   365 QSFASTHMNQHSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKHQ-KSGERLKEAGN 428

  Fly   403 INTSLMVLGRCLDA-ASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEEN 466
            |||||..||||:.| ....|.:...::||:||||||.:.|....|:.:..|||.|.|....|:|.
  Rat   429 INTSLHTLGRCIAALRQNQQNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDET 493

  Fly   467 LNVLNFASIAKNIIFKEPV----------IKQHRVSYC----------GFMEFSKMSTCEGGDYT 511
            |:...|:::|..::...||          ||:|.:...          ..:|.|.....:...|.
  Rat   494 LHAAKFSALASQLVHAPPVHLGIPSLHSFIKEHSLQVSPGLKKEGKADSDLEDSPEDEADISMYG 558

  Fly   512 KE-------------LEDENVRLQLEI---EQLKYDHVLQMQ---------------LLEEK--- 542
            ||             |::...:|||||   |::..:.|.|||               ||||.
  Rat   559 KEELLQVVEAMKALLLKERQEKLQLEIQLREEICNEMVEQMQQREQWCSERLDTQKDLLEELYED 623

  Fly   543 ----LRRELTATYQEIIQNNKKQYED-----ECEKKLLIAQRESEFMLSSQRRR------YEEQI 592
                |:..||..|||.||...::.|:     :..|:..:||:.....||.:|.:      ..:|:
  Rat   624 KLKILKESLTTFYQEQIQERDEKIEELETLLQEAKQQPVAQQSGGCELSLRRSQRLAASASSQQL 688

  Fly   593 EDLKDEIEELKNPASDT 609
            :::|.|:|:.|.....|
  Rat   689 QEVKAELEQCKTELGST 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_611260.1	KISc	89..477	CDD:276812	139/447 (31%)
		GBP_C	<512..603	CDD:293879	36/139 (26%)
		coiled coil	576..586	CDD:293879	2/9 (22%)
		coiled coil	592..603	CDD:293879	3/10 (30%)
Kif20a	NP_001101896.1	KISc_KIF23_like	62..504	CDD:276819	139/450 (31%)
		SMC_prok_B	<560..817	CDD:274008	37/146 (25%)
		RBD_KIF20A	601..656	CDD:409645	13/54 (24%)