DRSC/TRiP Functional Genomics Resources

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Protein Alignment sub and cos

DIOPT Version :10

Sequence 1:NP_611260.1 Gene:sub / 44870 FlyBaseID:FBgn0003545 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_477092.1 Gene:cos / 35653 FlyBaseID:FBgn0000352 Length:1201 Species:Drosophila melanogaster


Alignment Length:690 Identity:139/690 - (20%)
Similarity:243/690 - (35%) Gaps:237/690 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PRREVRSFLMARDPSIDRRFRP-RPNKKMRLFDNIQESEEESFSEYSDTESEYKYQSSEATEGAS 73
            |.||::..|        |.|.| .|.|..:..|...:| ::|.::....|.:....|.....|.:
  Fly    13 PHRELKDLL--------RSFGPTEPKKDAQAVDEGADS-KDSEAQVPAAEKDNPSISETDPNGNA 68

  Fly    74 CATSAADSSNV------ETGPQVFLRLRPVKDAS---KAYIVSEEA----NVLITSCKVDSTSNN 125
            ...|||||..:      ::|.:.:      .|::   :|..:|..|    :.|.....:||.:..
  Fly    69 EQDSAADSKTIPDANGNDSGQKDY------PDSAYCVQAIPISASALGLPSALPGGDPMDSIAAG 127

  Fly   126 VNRMEKH-FGFTSIFDSTVGQRDIYDTCVGPKI---MEEECVTIMTYGTSGSGKTYTLLGD---- 182
            :.::..| ...|....|:..|..:|...|.|.|   :|....:::|||..|.||:|||.|:    
  Fly   128 LIQVGPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDP 192

  Fly   183 ---DVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISA 244
               |...|::...:.:||:                                          .||.
  Fly   193 TLTDSTEGVVQLCVRDIFS------------------------------------------HISL 215

  Fly   245 HHQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGN 309
            |.:|                   :..:.|.||||....|.|||                      
  Fly   216 HPER-------------------TYAINVGFVEICGGDVCDLL---------------------- 239

  Fly   310 KGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSS-RSHCVFTVDILK--YNRSGIT 371
                   |:.::..|:.:.....|::|          ::|..| .:|.:||:.:.:  .::.|:.
  Fly   240 -------GMGNIHCTNVDAVFHWLQVG----------LSARQSLPAHTLFTLTLEQQWVSKEGLL 287

  Fly   372 TQ--SSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADI------ 428
            ..  |:..|.||.|:||..:...                  ||.|||...:.::..:.:      
  Fly   288 QHRLSTASFSDLCGTERCGDQPP------------------GRPLDAGLCMLEQVISTLTDPGLM 334

  Fly   429 ------IPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFA---SIAKNIIF--- 481
                  |||..:.||.||:.:..|:.:..:|:.|:||:::..|.|..|.||   ...:|.:.   
  Fly   335 YGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNT 399

  Fly   482 -----------KEPVIKQHRVSYCGFMEFSKMSTCEGGDYTKELEDENVRLQLEIEQ----LKYD 531
                       .|||.:               |....|..::....:|..||....|    :...
  Fly   400 YSDDNTMIVQPAEPVPE---------------SNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNA 449

  Fly   532 HVLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQI---- 592
            ..|..:|::.||..|:.              :::.|:.|.:.|...|.:.|::..|.::|:    
  Fly   450 EGLFSKLIDSKLITEVE--------------KEQIEEWLFLKQECEECLSSTEAMRQQKQLVPIL 500

  Fly   593 -----EDLKDEIEELKNPASDTDISDDPNESKSPIEILDD 627
                 ||:..|....::|.||.: :|..|||..|  .|||
  Fly   501 EAEEPEDVNSEAANSESPNSDNE-NDTDNESHRP--DLDD 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
subNP_611260.1 KISc 89..477 CDD:276812 82/425 (19%)
GBP_C <512..603 CDD:293879 19/103 (18%)
coiled coil 576..586 CDD:293879 2/9 (22%)
coiled coil 592..603 CDD:293879 3/19 (16%)
cosNP_477092.1 Kinesin 140..389 CDD:459720 73/366 (20%)
SMC_N 660..>999 CDD:481474
Blue background indicates that the domain is not in the aligned region.

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