Protein Alignment sub and Kif23

DIOPT Version :10

• Sequence 1: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_038937410.1
• Gene: Kif23 / 315740
• RGDID: 1308596
• Length: 1022
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 170/624 - (27%)
• Similarity: 280/624 - (44%)
• Gaps: 119/624 - (19%)

  Fly    82 SNVETGPQVFLRLRPVK--DASKAYIVSEEANVLITSCKVDSTSNNVNRMEKHFGFTSIFDSTVG 144
            :|::....|:.|:||:.  |......|.....|.:.:.:....:.|.:..|..:.|..:|.:...
  Rat    75 TNLKDPVGVYCRVRPLSFPDQECCVEVVNSTTVQLHTPEGYRLNRNGDYKETQYSFKRVFGTHTT 139

  Fly   145 QRDIYDTCVGPKIMEEECV-----TIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTV 204
            |::::|....|.:  ::.:     .:.|||.:|||||||:.|.....|::||.|..||.....
  Rat   140 QKELFDVVASPLV--DDLIHGKNGLLFTYGVTGSGKTYTMTGSPGSGGLLPRCLNMIFNSIGS-- 200

  Fly   205 FRSPKLKLINGSIVFLQDDASLKELQI---------RKKLLDLCPDISAHHQRLKQVIDGDHMFE 260
            |::.:       .||..:|.:..|:|.         :::.:.:....|:..|...:..|..::.|
  Rat   201 FQAKR-------FVFKSNDRNSMEIQCEVDALLERQKREAMPIPKTPSSKRQADPEFADMINVQE 258

  Fly   261 TKASTDV---SVL-VWVSFVEIYNELVYDLL------AIPPKQDKLGEVPRKNLKIV-------- 307
            ...:.:|   ||. |:||::||||..:||||      .|.|.:......|.:|.:.|
  Rat   259 FCKAEEVDEDSVYGVFVSYIEIYNNYLYDLLEEVQFDPIKPNRWNGCSTPMRNAEAVLPQSKMLR 323

  Fly   308 GNKGH-VFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILK------- 364
            .:|.| :::.|.|.|.|.|:|||..:...||::...|:|.:|..|||||.||::.:::
  Rat   324 EDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFSIKLVQAPLDADG 388

  Fly   365 ----YNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKN 425
                ..:..||. |.....|||||||.|.|...|.||:||.|||.|||.|..|::.....|....
  Rat   389 DNVLQEKEQITI-SQLSLVDLAGSERTNRTKAEGNRLREAGNINQSLMTLRTCMEVLRENQMYGT 452

  Fly   426 ADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHR 490
            ..::||||||||.|.:....|:.|:.|||.|.|..:.|||:|.|:.||.:.:.:....||.|
  Rat   453 NKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEESLQVMRFAEVTQEVEVARPVDK--- 514

  Fly   491 VSYCG-------------------------FMEFSKMSTCEGGDYTKELEDENVRLQLEIEQLKY 530
             :.||                         ...|..:..|:    ..::.||....:| ::.|:.
  Rat   515 -AICGLTPGRRYRNLPRAGPVGDEPLTEEILQSFPPLPPCK----LLDVNDEETLPRL-MDALEK 573

  Fly   531 DHVLQMQLLEEKLRRE---LTATYQEIIQ--NNKKQYEDE--CEKKLLIAQRESEF--------- 579
            .|.|: ||:.|:|.::   ..|.::|...  :||:.|..|  .||:.:|:.::||.
  Rat   574 RHRLR-QLMTEELNKQCVAFKALFKEFDNSLSNKENYIQEKLNEKEKVISGQKSEIERLEKKNKT 637

  Fly   580 ------MLSSQRRRYEEQIEDLKDEIE----ELKNPASD 608
                  :|......|||...:|:.|:|    :|:...||
  Rat   638 LEYKIEILEKTTTIYEEDKRNLQQELESQHQKLQREFSD 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_611260.1	KISc	89..477	CDD:276812	131/433 (30%)
		GBP_C	<512..603	CDD:293879	28/116 (24%)
		coiled coil	576..586	CDD:293879	3/24 (13%)
		coiled coil	592..603	CDD:293879	3/14 (21%)
Kif23	XP_038937410.1	KISc_KIF23_like	79..504	CDD:276819	131/436 (30%)
		SCP-1	<559..710	CDD:114219	31/120 (26%)
		MKLP1_Arf_bdg	866..968	CDD:465166