DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sub and kif20bb

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_021335955.1	Gene:	kif20bb / 100007502	ZFINID:	ZDB-GENE-030131-9684	Length:	1547	Species:	Danio rerio

Alignment Length:	683	Identity:	186/683 - (27%)
Similarity:	317/683 - (46%)	Gaps:	136/683 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NKKMRLFDNI--QESEEESFSEYSDTESEYKYQSSEATEGASCATSAADSSNVETGP-QVFLRLR 95
            |.|....|:|  ::..::.|||:|..                    :.||.::|... ||:||:|
Zfish     7 NHKPDRVDSITVEDLRKDLFSEFSKL--------------------SRDSVSLEKEHLQVYLRVR 51

  Fly    96 PVKDASKAYIVSEEA-------NVLITSCKVDSTSNNVNR----MEKHFGFTSIFDSTVGQRDIY 149
            |.....:|...|::.       .|::.:.|...|:.:..|    :.:.|.|:.::.....|::|:
Zfish    52 PFTSTERAEGESQDCISIEPPDTVILKAPKASLTARHSERFGPQLAQRFQFSQVYGPETTQKEIF 116

  Fly   150 DTCVGPKIMEEECV-----TIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTVFRSPK 209
            |...  |.:.:|.:     .|.|||.:.:|||:|.||.:...||:||:|..||...:..::....
Zfish   117 DGTT--KSLVKEVLDGGNSLIFTYGVTNAGKTFTFLGPESDGGILPRSLNVIFNSIEGRIYLQNN 179

  Fly   210 LKLINGSIVFL------QDDASLKELQIRKKLLD----------LCPDISAHHQRLKQVIDGDHM 258
            :| .:..:.|.      ||:.:..:..:.::..|          .....|:........::||.:
Zfish   180 IK-PHRCVDFTRLTKEQQDEEATNKRNLLRRFKDNDSQKTLSSMSSSSCSSFDSSTSSDMNGDSV 243

  Fly   259 FETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGN-KGHVFIKGLTSVF 322
            :..:.| .|...|||||.|||||.::|||...|.    |...|..|::..: |.:.|:|.|..|.
Zfish   244 YLDEDS-HVKFSVWVSFCEIYNESIHDLLDFVPN----GSHRRNALRLAQDVKSNSFVKDLKWVQ 303

  Fly   323 VTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSG---ITTQSSYKFCDLAGS 384
            |.|::|||:::::|::..:::||.:|..|||||.:|::.:|:....|   :.|.|....||||||
Zfish   304 VNSADEALKVVKIGRKNQSFSSTKLNNISSRSHSIFSIRMLRIEDVGVPRVQTISELSLCDLAGS 368

  Fly   385 ERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQ-KKKNADIIPYRDSKLTMLLQAALLGKE 448
            ||...|...|.|||||.||||||:.||:|::|....| :.|....||:|:||||..||....|:.
Zfish   369 ERCARTQNRGERLKEAGNINTSLLTLGKCINALRLNQTQSKFHQHIPFRESKLTHYLQGYFCGRG 433

  Fly   449 KLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEP------VIKQHR------VSYCGFMEFSK 501
            |..||:.:......|:|.||||.|:::|:.::...|      .:|:..      ::.....::::
Zfish   434 KACMIININQCASVYDETLNVLKFSAVAQKVVVLNPKPAPSIALKRSARDVSMIINNADKKDWTR 498

  Fly   502 MSTCEGGDYTKE--LEDEN------------------------------VRLQLEIEQLKYDHVL 534
            .|:..|.:.:.|  .||||                              ..||::||:|:...:.
Zfish   499 RSSIMGWEMSLEDVQEDENDEDMDEEEVESDDESIVDRTVLETVENQELCELQVKIEELQEKLIK 563

  Fly   535 QMQ---LLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLK 596
            :..   .||.::|.|:|..:.|:..|.:|.|.:.       .|||.|.:.....||
Zfish   564 EESEKLTLEARIREEVTTEFMELFSNMEKDYSER-------LQREKEIVEERAERR--------- 612

  Fly   597 DEIEELKNPASDT--DISDDPNESK-SPIEILD 626
              :|.|||..:.|  :::.|.|.:| :.:|:||
Zfish   613 --LEILKNLVNRTIEEMTTDENAAKEAKMELLD 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	134/424 (32%)
		Kinesin	93..479	CDD:278646	132/422 (31%)
		GBP_C	<512..603	CDD:303769	26/125 (21%)
		coiled coil	576..586	CDD:293879	2/9 (22%)
		coiled coil	592..603	CDD:293879	1/10 (10%)
kif20bb	XP_021335955.1	Motor_domain	42..462	CDD:328930	134/427 (31%)
		SMC_N	<544..1161	CDD:330553	31/118 (26%)
		TOP2c	<1287..1532	CDD:330395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3418
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25532
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.970