DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sad and Cyp27a1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_849178.2	Gene:	Cyp27a1 / 301517	RGDID:	727915	Length:	533	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	161/572 - (28%)
Similarity:	249/572 - (43%)	Gaps:	112/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRWLRHLLDQLLVRILSLSL----FRSRCD-PPPLQRFPATELPPAVAAKYVPIPRVKG---LPV 67
            |||.  |||   .|::...|    .|::.. |..|:...:||.|.....:    ||::.   ||.
  Rat     9 LRWA--LLD---TRVMGHGLCPQGARAKAAIPAALRDHESTEGPGTGQDR----PRLRSLAELPG 64

  Fly    68 VGT---LVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQ 129
            .||   |..|...|...|||:.......:|||::.... ||:..|.::||.|:..|.:.||:||.
  Rat    65 PGTLRFLFQLFLRGYVLHLHELQALNKAKYGPMWTTTF-GTRTNVNLASAPLLEQVMRQEGKYPI 128

  Fly   130 HPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRR 194
            ....:.|..:........|:|..:|.:|.|.|..||:.:|                        :
  Rat   129 RDSMEQWKEHRDHKGLSYGIFITQGQQWYHLRHSLNQRML------------------------K 169

  Fly   195 TAEAAAIP----------LAESGEIRSY-----ELPLLEQQLYRWSIEVLCCIMFGTSVLTC--P 242
            .||||...          :|...::|:.     ::|.:...||..::|.:|.|:|...| .|  |
  Rat   170 PAEAALYTDALNEVISDFIARLDQVRTESASGDQVPDVAHLLYHLALEAICYILFEKRV-GCLEP 233

  Fly   243 KIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCIRVQE 307
            .|......|.:.|..:|::|. .:||.|:.::.| ||.|:.:..|.|.:...|..:|..  :|||
  Rat   234 SIPEDTATFIRSVGLMFKNSV-YVTFLPKWSRPL-LPFWKRYMNNWDNIFSFGEKMIHQ--KVQE 294

  Fly   308 DQRRPHDEALYHRLQAADVPGDMI---------KRI---------FVDLVIAAGDTTAFSSQWAL 354
                     :..:||||...|..:         |.:         |.:|::|..|||:.:..|||
  Rat   295 ---------IEAQLQAAGPDGVQVSGYLHFLLTKELLSPQETVGTFPELILAGVDTTSNTLTWAL 350

  Fly   355 FALSKEPRLQQRLAKE--------RATNDSRLMH-----GLIKESLRLYPVAPFIGRYLPQ-DAQ 405
            :.|||.|.:|:.|.||        :...:....|     .:|||:||||||.|...|.:.: :.:
  Rat   351 YHLSKNPEIQEALHKEVTGVVPFGKVPQNKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETE 415

  Fly   406 LGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWC---IGETEQVHKSHGSLPFAIGQRSCI 467
            :.|....|:|..:|..|...||||.|.:||...|.||.   ..:...:....||:||..|.|||:
  Rat   416 INGFLFPKNTQFVLCHYVVSRDPSVFPEPESFQPHRWLRKREDDNSGIQHPFGSVPFGYGVRSCL 480

  Fly   468 GRRVALKQLHSLLGRCAAQFEMSCLNEM-PVDSVLRMVTVPDRTLRLALRPR 518
            |||:|..::..||.|...::|:.....| .|.||.|:|.||.:.:.|....|
  Rat   481 GRRIAELEMQLLLSRLIQKYEVVLSPGMGEVKSVSRIVLVPSKKVSLRFLQR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	136/492 (28%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58		6/23 (26%)
		cytochrome_P450	91..527	CDD:425388	133/474 (28%)
		Sterol-binding. /evidence=ECO:0000255	386..400		6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351010
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.760