Protein Alignment sad and Cyp27a1

DIOPT Version :10

• Sequence 1: NP_650123.1
• Gene: sad / 44858
• FlyBaseID: FBgn0003312
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_849178.2
• Gene: Cyp27a1 / 301517
• RGDID: 727915
• Length: 533
• Species: Rattus norvegicus
• Alignment Length: 572
• Identity: 161/572 - (28%)
• Similarity: 249/572 - (43%)
• Gaps: 112/572 - (19%)

  Fly    11 LRWLRHLLDQLLVRILSLSL----FRSRCD-PPPLQRFPATELPPAVAAKYVPIPRVKG---LPV 67
            |||.  |||   .|::...|    .|::.. |..|:...:||.|.....:    ||::.   ||.
  Rat     9 LRWA--LLD---TRVMGHGLCPQGARAKAAIPAALRDHESTEGPGTGQDR----PRLRSLAELPG 64

  Fly    68 VGT---LVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQ 129
            .||   |..|...|...|||:.......:|||::.... ||:..|.::||.|:..|.:.||:||.
  Rat    65 PGTLRFLFQLFLRGYVLHLHELQALNKAKYGPMWTTTF-GTRTNVNLASAPLLEQVMRQEGKYPI 128

  Fly   130 HPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRR 194
            ....:.|..:........|:|..:|.:|.|.|..||:.:|                        :
  Rat   129 RDSMEQWKEHRDHKGLSYGIFITQGQQWYHLRHSLNQRML------------------------K 169

  Fly   195 TAEAAAIP----------LAESGEIRSY-----ELPLLEQQLYRWSIEVLCCIMFGTSVLTC--P 242
            .||||...          :|...::|:.     ::|.:...||..::|.:|.|:|...| .|  |
  Rat   170 PAEAALYTDALNEVISDFIARLDQVRTESASGDQVPDVAHLLYHLALEAICYILFEKRV-GCLEP 233

  Fly   243 KIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCIRVQE 307
            .|......|.:.|..:|::|. .:||.|:.::.| ||.|:.:..|.|.:...|..:|..  :|||
  Rat   234 SIPEDTATFIRSVGLMFKNSV-YVTFLPKWSRPL-LPFWKRYMNNWDNIFSFGEKMIHQ--KVQE 294

  Fly   308 DQRRPHDEALYHRLQAADVPGDMI---------KRI---------FVDLVIAAGDTTAFSSQWAL 354
                     :..:||||...|..:         |.:         |.:|::|..|||:.:..|||
  Rat   295 ---------IEAQLQAAGPDGVQVSGYLHFLLTKELLSPQETVGTFPELILAGVDTTSNTLTWAL 350

  Fly   355 FALSKEPRLQQRLAKE--------RATNDSRLMH-----GLIKESLRLYPVAPFIGRYLPQ-DAQ 405
            :.|||.|.:|:.|.||        :...:....|     .:|||:||||||.|...|.:.: :.:
  Rat   351 YHLSKNPEIQEALHKEVTGVVPFGKVPQNKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETE 415

  Fly   406 LGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWC---IGETEQVHKSHGSLPFAIGQRSCI 467
            :.|....|:|..:|..|...||||.|.:||...|.||.   ..:...:....||:||..|.|||:
  Rat   416 INGFLFPKNTQFVLCHYVVSRDPSVFPEPESFQPHRWLRKREDDNSGIQHPFGSVPFGYGVRSCL 480

  Fly   468 GRRVALKQLHSLLGRCAAQFEMSCLNEM-PVDSVLRMVTVPDRTLRLALRPR 518
            |||:|..::..||.|...::|:.....| .|.||.|:|.||.:.:.|....|
  Rat   481 GRRIAELEMQLLLSRLIQKYEVVLSPGMGEVKSVSRIVLVPSKKVSLRFLQR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	CYP24A1-like	91..512	CDD:410677	133/473 (28%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		6/23 (26%)
		cytochrome_P450	91..527	CDD:477761	133/474 (28%)
		Sterol-binding. /evidence=ECO:0000255	386..400		6/13 (46%)