DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	562	Identity:	111/562 - (19%)
Similarity:	208/562 - (37%)	Gaps:	156/562 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PLQRFPATELPPAVAAKYVPIPRVKGLPV-------------------VGTLVD-----LIAAGG 79
            |:|......:|..|....:|:..:.||.:                   :|.|:.     .:..|.
Mouse     8 PMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGS 72

  Fly    80 ATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHA 144
            |.:.:      :|.||...|..:.| ::.:.:|.::.|..|.:|     .|        |..:..
Mouse    73 ACNYY------NKMYGEFMRVWISG-EETLIISKSSSMFHVMKH-----SH--------YISRFG 117

  Fly   145 CQRGLFFMEGAEWLHNRRILNRLLLNGNLN-WMDVH---------------IESCTRRMVDQWKR 193
            .:|||..:    .:|.    |.::.|.|.: |..:.               :|.|...:.....|
Mouse   118 SKRGLQCI----GMHE----NGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDR 174

  Fly   194 RTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCC---IMFGTS---VLTCPKIQSSLDYFT 252
                     |.|..:...|             ::||..   ||..||   .|..|..:|:
Mouse   175 ---------LGEVTDTSGY-------------VDVLTLMRHIMLDTSNMLFLGIPLDESA----- 212

  Fly   253 QIVHKV---FEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIID---HCIRVQEDQRR 311
             ||.|:   |.....|:..|....:|..|  :|.:|.:|.::..|.|.:::   |.:...|....
Mouse   213 -IVKKIQGYFNAWQALLIKPNIFFKISWL--YRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLED 274

  Fly   312 PHDEA--LYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKERAT- 373
            ..|.|  |....:..|:..:.:.:..::::|||.||.:.:..:.|..:::.|.::..:.||..|
Mouse   275 CMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTV 339

  Fly   374 -----------NDSRLMHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGR- 426
                       .:.:::...|.||:|..||...:.|...:|..:.|:.::|.|.::|::   ||
Mouse   340 VGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNI---GRM 401

  Fly   427 -------DPSHF--EQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGR 482
                   .|:.|  |..|:.:|.|:             ..||..|.|.|.|:.:|:..:..:|..
Mouse   402 HRLEYFPKPNEFTLENFEKNVPYRY-------------FQPFGFGPRGCAGKYIAMVMMKVVLVT 453

  Fly   483 CAAQFEMS-----CLNEMPVDSVLRMVTVPDRTL-RLALRPR 518
            ...:|::.     |:..:|..:.|.:....||.| .:...||
Mouse   454 LLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	99/514 (19%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	101/513 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100