Protein Alignment sad and Cyp19a1

DIOPT Version :10

• Sequence 1: NP_650123.1
• Gene: sad / 44858
• FlyBaseID: FBgn0003312
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_031836.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Alignment Length: 562
• Identity: 111/562 - (19%)
• Similarity: 208/562 - (37%)
• Gaps: 156/562 - (27%)

  Fly    39 PLQRFPATELPPAVAAKYVPIPRVKGLPV-------------------VGTLVD-----LIAAGG 79
            |:|......:|..|....:|:..:.||.:                   :|.|:.     .:..|.
Mouse     8 PMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGS 72

  Fly    80 ATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHA 144
            |.:.:      :|.||...|..:.| ::.:.:|.::.|..|.:|     .|        |..:..
Mouse    73 ACNYY------NKMYGEFMRVWISG-EETLIISKSSSMFHVMKH-----SH--------YISRFG 117

  Fly   145 CQRGLFFMEGAEWLHNRRILNRLLLNGNLN-WMDVH---------------IESCTRRMVDQWKR 193
            .:|||..:    .:|.    |.::.|.|.: |..:.               :|.|...:.....|
Mouse   118 SKRGLQCI----GMHE----NGIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDR 174

  Fly   194 RTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCC---IMFGTS---VLTCPKIQSSLDYFT 252
                     |.|..:...|             ::||..   ||..||   .|..|..:|:
Mouse   175 ---------LGEVTDTSGY-------------VDVLTLMRHIMLDTSNMLFLGIPLDESA----- 212

  Fly   253 QIVHKV---FEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIID---HCIRVQEDQRR 311
             ||.|:   |.....|:..|....:|..|  :|.:|.:|.::..|.|.:::   |.:...|....
Mouse   213 -IVKKIQGYFNAWQALLIKPNIFFKISWL--YRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLED 274

  Fly   312 PHDEA--LYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKERAT- 373
            ..|.|  |....:..|:..:.:.:..::::|||.||.:.:..:.|..:::.|.::..:.||..|
Mouse   275 CMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTV 339

  Fly   374 -----------NDSRLMHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGR- 426
                       .:.:::...|.||:|..||...:.|...:|..:.|:.::|.|.::|::   ||
Mouse   340 VGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNI---GRM 401

  Fly   427 -------DPSHF--EQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGR 482
                   .|:.|  |..|:.:|.|:             ..||..|.|.|.|:.:|:..:..:|..
Mouse   402 HRLEYFPKPNEFTLENFEKNVPYRY-------------FQPFGFGPRGCAGKYIAMVMMKVVLVT 453

  Fly   483 CAAQFEMS-----CLNEMPVDSVLRMVTVPDRTL-RLALRPR 518
            ...:|::.     |:..:|..:.|.:....||.| .:...||
Mouse   454 LLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	CYP24A1-like	91..512	CDD:410677	98/478 (21%)
Cyp19a1	NP_031836.1	CYP19A1	72..485	CDD:410709	96/486 (20%)