|
Fly 11 LKRT--RLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSD------EFGTAHNSNVNASKV-- 65
|::| |:|..|:|.|:..|.||.||...:|.|:.. ||:. .|..:.|..:...|.
Worm 2 LRKTNLRMGTADVYKQNKNQEEDMLTTERLKKGYQM--PLTQYELQSLVFNASENKLIRLEKAQK 64
Fly 66 --SAFFSGVLAKKEELMTLPDTGRK--KQQINCKDNFWP------VSPRRKCTVDAWFKDLAGNK 120
.:..:.|:.||.|.....|..|| |:|:.| |.| :|.|.| :|..||...
Worm 65 RSQSMIASVIHKKGEFHMNYDRERKIPKEQLPC---FAPHNWKRILSDRVK-----FFSALARGT 121
Fly 121 PLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSF-TESKNKKRSIYDPAA--- 181
||..|::|.|.|.:||.:|:...:..::..||.|.:||.. .|.| :.||.:|:::.|.|.
Worm 122 PLQQLSQRIPGFRRKELLFLEFSDYNISYDRAIWCVKLLC--ILGFNSSSKTQKKTLLDVATLEL 184
Fly 182 ------------------------------EW---TGNMIKFM--------KELLPKLQEYYQQ- 204
.| ||.| |:| :|.|..|.|.:.|
Worm 185 SQACNKTTIWLVTQLYKSFRNPIKRREATKTWNYLTGFM-KYMFDDGVLDKQEFLNDLTEVFNQL 248
Fly 205 --------------------------------------------------NHDK-------SSSN 212
..|| .|:|
Worm 249 FLQKNFKNPSVLSTFMKYYVYFVEDLSSSLVLARRSSTLLCQALGFLFEMAQDKRKIDAYYDSAN 313
Fly 213 GT--------------------------------------------------------TSGSLTA 221
.| .:|||..
Worm 314 KTFIKKEFENEDGEIYEFEDYDDFIDMLDEIPDVPYFDETDKTPEAQAEELIKQHEKRKAGSLKK 378
Fly 222 A----------------GNGPASNGST------------------GTSSINSVTGSSASTNVIPV 252
: ...|::..|. |..|.||:...|.|....|
Worm 379 SERRRRRGLSKNRPKKMPQNPSNEASLDHDKVQIKQEPMDYDEYGGQQSDNSMDYDSFSHQYDP- 442
Fly 253 PSMASPLP--PIHS----PANGQQAAPGGGVNAGSVMPTT-----GSL--------GGV-VGGPG 297
...||| |:|: .....:......:...||.|.. ||: ||| :..|.
Worm 443 --SYEPLPFKPLHTDIPKKLTDDEEFKYMKIGKRSVTPERISGRYGSMTYPFWIQQGGVGIDPPK 505
Fly 298 SSVVGGAAGAGA------------AVPPGSTISGIGSQFE------------------------- 325
..|:..:..... :.|..|....:..:.|
Worm 506 DEVLDFSNPTPTETVNTQPQIDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKEK 570
Fly 326 ------------------------DSRNALKYWKYCHQ-----------LSKYMYEESLLDRQEF 355
|..:|.:..|...: .||.....:..::.|.
Worm 571 SVDEHTNDLDVPINPDDAEMADANDKTDASEKQKLVEEEPTGKENEDDTSSKTAKTSTSAEKSEA 635
Fly 356 LNWILDLLDKM-----------------------------------RTQASFDEPLKKLVLSFAL 385
.: |:|..||: .|:.:.:|||: :
Worm 636 PS-IVDSNDKIDKEPNASSTSNDETSKDDTVPMESDPPAATEKPKESTEITTEEPLE-------V 692
Fly 386 QYMHDFVQSERLCRKMAYIV-SKKLAQLLNTVV--------------------EQQTIKELDEPK 429
....:..:||:.......|: |.|.|...:.|| |::..|..|...
Worm 693 DKAPEVDKSEKEHEDDIMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDV 757
Fly 430 LQQDPYELALQEQMS-------------------------------------------CPHHRDI 451
...:|.::...|::: |....:.
Worm 758 ADNEPEKIYTDEELAEIKIRKEKEMKIATLASHIKEKMVSDKKWKEKTSHAGWRTLDQCSQFSEA 822
Fly 452 VLYLSTILQIITIECPTALVWSGIAA------HRAPSSLLGSPLDHLPLAPSVLPMPTRCPRTNH 510
:..||:::|.:....|.:.||:.::. ||....|.|||||:||.....||:.... .
Worm 823 LHLLSSMVQYMACVTPESFVWNDLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVMEGV----E 883
Fly 511 EIRRQLRAAESDIVLRTQHAEQRWF--AAKWLSAGK--NQYTSVLATLDHLDTHCFDRMEHNNSI 571
|:...||....:||.|:|.||.||. ||...|.|: :....|:..:|::| :|..|:|
Worm 884 EVVDCLRLRHCEIVRRSQAAEDRWLPNAAFLQSFGRIIDTCVDVIGIMDNID------VEKPNAI 942
Fly 572 DTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWAVSGQRWGEHRAMVVAILLDKR 636
.....::|.. |..:|.::......::.:|.::.:|.|..||..:|.||
Worm 943 TNAGLRLFAF--------------REKFEKQEALLKTMLMFKWCITEEREGSFRATYIAKLL--- 990
Fly 637 QIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVSSPQQRTEFTN 701
:...|::.:::: .|..::| :...|:..:.| :| .|...:..|.:
Worm 991 ----------RFGMDQNPENTI-GGWQVMD-------LFFKFMSTEGP---KH-GSKMYQAHFDS 1033
Fly 702 LVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTATKTSPPPPAPPPTTTHGFDDDG 766
.|.:...::|..:||....:..|....||
Worm 1034 TVAIMIEMMREKIFSITDILRELEKDSDL------------------------------------ 1062
Fly 767 FGGGLDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGETNPGGSISRHYVYTK 831
:::...::....:.:..|.::.::.|.||..|: .|:. |:
Worm 1063 ----------DYNAPLMERQRKQKIPKISKRHRKPETPDDTKL---------------VHFT-TE 1101
Fly 832 HFP------------------IPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIG 878
:.| :||.| :...:.|...|.:||||:....:......:.:.|.|.
Worm 1102 YTPKRLFMGKKMDLLERMIIILPQLD--VDEDTDEYRLRRLLLFGLKPAANVYFRRARAIYKSIT 1164
Fly 879 KLFTKKFSIDVAAAGHV----KKHSRNEFN-----FEATTSKCQQMAYFDQHVVTAQCAANVLEQ 934
|.||.:..|:...:..| ||.::|..: |.|.| |.|||::..:...|.::.
Worm 1165 KEFTTRLYIEFDRSSKVTTAHKKINQNRLDDLLRQFRAQT-------YHDQHLILERIVYNFIDG 1222
Fly 935 LNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDSLLKELPEVEHQL-QLKKSNLVRSYT 998
:.||...|.:.:|..|....:.::.|.:::|.|:.:..:.:...|..|:.:: ..:...|...|.
Worm 1223 IGGFLKKNCDDVPAPEVANIICEMYEFSMDITSIFDFFEMVNPYLKAVDDKIAHFRMDVLPDMYY 1287
Fly 999 TSLALYIVSILRRYHSCLLLSP------EQTLSVFEGVCRTIRHVSNPSECTSAERCIIAYLSDL 1057
|..|...||...::....||.| .|...:.:.:.|...|: .|...|.:..:: .
Worm 1288 TETAFIFVSFFMKHWQRFLLHPRACAIVNQCFVLIQDMIRADDHM-----ITCWGRTVAIFV--F 1345
Fly 1058 HESCVLLQGKEQSTEYYQQLQCIKRFKDIFNTPEQLDLPPQGYNPLLLQELFMAPR---RGGKL- 1118
|....:.....|:.|:..: ...|..:|...:.:||....:| |.|...: |||.|
Worm 1346 HARKAIANAGLQNEEFLAE---DSHFWRVFPNAQHVDLDVGYFN-----EDFAGVKLQLRGGTLR 1402
Fly 1119 -----DPHWLGT---------LH-ESPANVYSFVSNALIAVCRETDN-ERLNDVALACAELTASC 1167
|..||.: .| :.|...||||..|.:...:...| :|:|::|..||.:||:.
Worm 1403 YDSYNDFKWLVSNMKPNLKKKPHLKRPNTRYSFVVRAFMEARQHGRNFDRINELANYCANITAND 1467
Fly 1168 NVLSEEWIYALQSLCSGSKSPRYP--HLGGQVDIGQLKTHNALAVFVCILVARHCF----SLADF 1226
..|||.||.|::.||..|....|| .:..|:||....||.:|..|:..|..:..| .||:
Worm 1468 PPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFITCLAGKSAFYIPRLLAE- 1531
Fly 1227 VSKFALPTLAR------------------SVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQP 1273
::|...|.:.| |.:.....|| :||.|..| |.|:: .
Worm 1532 LTKHVFPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLS-EAEPGVCL-CLLII----------C 1584
Fly 1274 GMYSVSTSPNPL--HAVG---------NDFSIRLSCDRHLLVGAH---KTI-PIAAVLAVLK--- 1320
|:..|...|..| |..| |....|:....|.....| :|: .|:.:|..|:
Worm 1585 GLCCVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTLGHISQLLEALQSRC 1649
Fly 1321 --AILIVVDNAALKTPLASGSGTSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQ--------RP 1375
|.|::..|..:|.| ||..:: ||
Worm 1650 RDANLVLPKNFPIKNP---------------------------------PKHQQELHREKAPYRP 1681
Fly 1376 ADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQISLLEFAQAVLKQICAQEHVLERCLKNAEQ 1440
..|..|..|....: .:|..| .:.:..|.|....:...|:.:.:.|| .:|
Worm 1682 QYLFNIAKTVQFVI----------CEQDWV----TLRMFRFFQTRKMEAFNQDKLKQNCL--GQQ 1730
Fly 1441 LCDMIIDEMLTAKQAQRVLHMICYPEPEFNIISELDQRSMIVRILENLGQWTLRISWLDLQLMYR 1505
:..|.:......:...::.. ..::.:::.:.::|..:..|..|.:..||.||.:
Worm 1731 ILRMALRRRTERENVHKLFE-----------AHKISKKATVDKVLSFMNLWNFRATLFDLMLMIK 1784
Fly 1506 Q----SLSNNAE-----LNVWLDTVARAAIDVF---HMEEVVLPGAVKATH---KPKPSTWLVAP 1555
: ..|.:|: .:..:..:.:...|:| :..::.:|.|...|. ......||:||
Worm 1785 EISPDGNSRHAQQGAIAADALMSEIGKCCRDMFLSAYKTKIKMPIAKTLTDFRLSDINKFWLIAP 1849
Fly 1556 LIAKLTP---------------AVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSC 1605
|: ::.| .|..:.||.|..::::.....|.....|
Worm 1850 LV-RMCPKPINIPPQYANTTVGTVAAKFLREAALLMDTPPTTPKERLLQC--------------- 1898
Fly 1606 HSSNSYGLGGVPARNKKMPLDYQPFLGLILTCLKGQ--DEYKENLLVSLYAQLSQCLQSFAELDT 1668
|:.:..| ||:.:|||||:.: .:.|:..|.|||.||.: :|
Worm 1899 ----SWAMSKV------------PFINMILTCLQCEKMQQSKDVFLQSLYTQLQR--------ET 1939
Fly 1669 IGGIDEPQA-----REEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNR 1728
:. |..:. |.|..|....|.:|:|.:::.|.| :|....|.:|:.||:..|:::....:
Worm 1940 LR--DHHRRSNWTNRREHRDCTIFRITLIGYIYKEILK-ATHVETWGLLIFQLMFHGIINPVREK 2001
Fly 1729 ELFTTVVDMLATLVHSTLVSDDERH--------------YMNLMKKLKKEIGEKNNASIR-VIRQ 1778
.::.|..|||..:|..|||..|..: |..||||::||:.|:.....| .:.:
Worm 2002 LIYETCFDMLHHMVLWTLVDGDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLHR 2066
Fly 1779 LLPLYKQPTEVIACEHSGMDTKGNKICDIDKKQLR------------ISDKQRISVWD------- 1824
.||:.|.....|:.:......|.|: .:.||.|. ..:|.:.:.::
Worm 2067 FLPIGKMQMSTISYKKYQKRPKVNQ--KMSKKFLAGEGLKNGKYSFLPEEKAKTNAFEHTDHLGD 2129
Fly 1825 -ILEGHKNPAPLSWVW--FGAVKLERKPLTYEEAHRNLKYHTHSLV--KP----SSYYYEPLPLP 1880
|::| .|.: |...:|::.....:...|:..:|||.|. :| |...::.:.|.
Worm 2130 LIVKG-------GWKFRMFQTTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLA 2187
Fly 1881 PEDIE-------PVP-------------------------------------------------- 1888
|.||| |||
Worm 2188 PPDIEITKIIEQPVPVIDEEEAKKRAEEEKEAAEKKEESKNAEDEKNKNNAENKKDTKEGEKGKS 2252
Fly 1889 -------EKICIKDEMKAD----------------------------------TPSSVDQSPSAV 1912
||...||..|.| .|:.|.:||:..
Worm 2253 KDKEKDGEKEKCKDASKKDDVTSEKNELEKRASDAAAATNAPETNKDMDTSTPKPAPVTRSPATR 2317
Fly 1913 VGGTGRGRGKG----------------------TTTRKRKP----KNP------------KTPPV 1939
..|.||.|..| .||:...| .|| ..||:
Worm 2318 GRGGGRKRNSGARGGGPRAKRANSRADTAQAAAATTQWNAPIANTSNPAAGGNFHAAMRGNQPPM 2382
Fly 1940 VN-----------------TQQQQPQLAQQ----------------------PQQPQNVQQ---- 1961
.| .::::..||.. |..|.....
Worm 2383 SNGSSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAMGNTSSMPPSGPPMPMGSSMQSAG 2447
Fly 1962 --QQLQQQQQQQQHMQQQHMQQQQ--MQPNQMGQMP--------MNMPMNMQQF------APNPN 2008
||||..|:.|.......|.|.. |..:...|.| ||.|: |.|: ||||.
Worm 2448 ATQQLQGMQKHQMGGSMSGMNQNMGGMNQSMSHQAPPPYSSTNEMNRPL-MNQYGGPHFAAPNPG 2511
Fly 2009 NM-------------------------------------------------------MQQNAMLQ 2018
.: ||:.|.::
Worm 2512 PLNRSSGPVSSETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMK 2576
Fly 2019 QQQ-------------------------------------------------------------- 2021
:||
Worm 2577 EQQLLERKRAIEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEA 2641
Fly 2022 ---------------QQQMQ--------------------------------------------- 2026
|:||:
Worm 2642 EERMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEAR 2706
Fly 2027 -------QMGNNPMQQQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAPQQQQPP 2084
::....|:|| ...|.||.|| ||.|: .||||
Worm 2707 MREAREAELSRQRMEQQ-----RRSQQNPYMN------------------QQGQY-----SQQPP 2743
Fly 2085 QPYH-----NQYAPHQQNMQSNRIERPP-------LNANSKQALSQM---LRQRQPFQ----QQA 2130
..|. |.|.|.||..|....::|. ..|..:|..:|| ::|:|..| ||:
Worm 2744 PSYQQSSYPNNYQPGQQGNQPPNYQQPSHQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQS 2808
Fly 2131 QQGPGG----------GFN---------PMQQQ-----PQASQQQPGPQQQMN--PNQMRQQQMN 2169
..|||| |:| .|||| .|...||||..:.|: ||:...||..
Worm 2809 FSGPGGINQPSQPGYSGYNQQGGQGQQGQMQQQRNPFGNQQDMQQPGAAKLMHAKPNEAHAQQYQ 2873
Fly 2170 PQQNPQSVAA-------FNAMQ-QQPQQNAQQQQM--------------NPNQQQQ--QQFMRGG 2210
..||..|:|. |.|.. |..|.||||||. .|..||| .....|.
Worm 2874 HTQNQLSLAQKEKEKQYFQAKNLQASQANAQQQQQRFGDVVAGNVAGYGRPYGQQQLGASDQMGT 2938
Fly 2211 NMRPGMAPNQMNQMNMGGQG-----MSQNPMM------------QQQIPQNMVGMVN-------- 2250
:..||.:.::|||.:...|| ..|.|:: |||||.......|
Worm 2939 SQLPGASTSRMNQGSSNPQGGMQSYQQQQPVLGQPGPIQTGQSTQQQIPAQSQQQYNSGRPQMHT 3003
Fly 2251 -PNANQM--MQSGGAQG--GNGVGVGVG-VGVGGAGNN------------------------PNM 2285
|..|.| ....||.| .|.:|.|.. .|.|..|.| ||.
Worm 3004 TPTKNDMSARAPSGAMGQIANRMGHGTNPQGYGSTGQNVPGGYQQGQQQSGQGSYPQAQQQQPNQ 3068
Fly 2286 GMGGMPQQGMIQQQPQQQP--------QQQVQF----------QNFQNQ-----YQQ--QQQQGM 2325
..|...|.|...||.|||| |...|| |:..|| ||: |||||.
Worm 3069 YSGSNQQVGQQAQQQQQQPLNQNVSQSQSAAQFGRPSQDSAYQQSGYNQTGNQSYQRPDQQQQGA 3133
Fly 2326 QQQGGGAGVGVGVGMAPN----QQQQQQANMMGNFNPQMQQGNRNNPDFMAAAAV------AQQQ 2380
||.... |...|.| |||.||.......:.|.||..:...:.||.:|. .||.
Worm 3134 QQNQWS-----GSNQAQNQLRSQQQAQQPLQQPQQSQQFQQPAQQAKNPMAQSAQYGGFGGQQQG 3193
Fly 2381 QQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVV---------------------- 2423
..||||.::.| ..|.|.....:.....|.....|.|..|..
Worm 3194 YDQQQQGQIAP--QQAQNPQASQSYGQQQTQQNRYGMGSSGYTANSGGSSNILNQSMEESGLNQG 3256
Fly 2424 ---------GQVPPYARQQSAGGGKPGVLNTQQQFQQQQQQQQQLRHQMMQLQGMGGGAGGGMGA 2479
.|....::.|.:|.|.|| .|.|.||.|:||::..|. .|||....|..|.
Worm 3257 FSGASSNASSQQGGSSQMQQSGYGMPG-----NQMQMQQNQKQQVQRGMP--TGMGQTNMGQSGM 3314
Fly 2480 GPQQGGGAVG---GGAGGGMVPQQQSMNQQQTPNLVAQLQRQNMM-----------GQQQYQP 2528
| |.|.|..| .|.|||:..|.|...|.|.|. |:|.|.|..| ||||:||
Worm 3315 G-QSGMGQTGMSRSGLGGGIGQQGQQSQQPQQPQ-VSQQQNQRGMNPGAQLPPYSTGQQQHQP 3375
| 
