|
Fly 7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70
|:|||||.||||||:||||.||:|||||..|||.||...|..: ||.|:|.|..:|.||:.|:||
Human 10 EQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFS 74
Fly 71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKK 135
.:||:|.:|.|..|||:||.|:|.|||:|.|:.|.:..:.:||.||||||||..|||:.|..:||
Human 75 SILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKK 139
Fly 136 EEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQE 200
|::|..|.:..|.|.||||.||::.||..:.:|:|.|||...||..|||....::::|.|.|:.:
Human 140 EDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISD 204
Fly 201 YYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPSMASPLPPIHSP 265
:| |..||: |:||. |:||
Human 205 FY---HMASST-----------GDGPV------------------------------PVPP---- 221
Fly 266 ANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISGIGSQFEDSRNA 330
:...|
Human 222 ------------------------------------------------------------EVEQA 226
Fly 331 LKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSE 395
:|.|:|..:|:.:|::|.:|::.|:|.||||:|:|:| ..|:.|.||:|...|||..:||||.
Human 227 MKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIR---PMDDDLLKLLLPLMLQYSDEFVQSA 288
Fly 396 RLCRKMAYIVSKKLAQLLNTVVEQQTIKELDEPKL---------------------------QQD 433
.|.|::||..:::|:.||: |.|.| ...
Human 289 YLSRRLAYFCARRLSLLLS-----------DSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMS 342
Fly 434 PYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLLGSPLDHLPLAPSV 498
|.:||..:.:||..|..:|..||.:||.:|:.||:||||: .:.:...|:..|||||.|.:|||.
Human 343 PVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWN-YSTNENKSANPGSPLDLLQVAPSS 406
Fly 499 LPMPTRCPRTNHEIRRQLRAAESDIVLRTQHAEQRWFAAKW--LSAGKNQYTSVLATLDHLDTHC 561
||||......|.::|.::...|..|..|.:..|.||...|. .:||.. .:.||.||:.||.||
Human 407 LPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVT-ISRVLHTLEVLDRHC 470
Fly 562 FDRMEHNNSIDTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWAVSGQRWGEHRA 626
|||.:.:||::|||.:|| ..::.::..:|.| .|:..|.:|||||||.:|.|:|||
Human 471 FDRTDSSNSMETLYHKIF---WANQNKDNQEVAP-------NDEAVVTLLCEWAVSCKRSGKHRA 525
Fly 627 MVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVS 691
|.||.||:|||.::.:.... :|...|:|:|::|.:.....|||||:||:.|||..||.|.: .:
Human 526 MAVAKLLEKRQAEIEAERCG-ESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSD-PN 588
Fly 692 SPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTATKTSPPPPAPPP 756
|..::.||.|||.||...||||||||:|||.|||||||| :....|.|..|....
Human 589 SECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-----------SVTASTRPRSPVGEN 642
Fly 757 TTTHGFDDDGFGGGLDFK--------HNEFDD--SNVDDDLDKLVQNIK-EKGQQHEAPDSPKIG 810
...|...|. |.| |...|. :|:.|::|| .:.| :.|.:. |...
Human 643 ADEHYSKDH------DVKMEEQSIMAHMGIDSGTTNIFDEVDK--SDFKTDFGSEF-----PIFS 694
Fly 811 P-PGDGETNPGGSIS----------------------------RHYVYTKHFPIPQDDPSMSSYS 846
| ||:...|...|:. ||..|..|||||.|:.| |
Human 695 PMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESS----S 755
Fly 847 SESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAAAGHVKKHSRNEF----NFEA 907
.|.|||.|||:||||||||.:|.:||::|:|.|:..||.:.:.......:|..:|:. ..|.
Human 756 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLET 820
Fly 908 TTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELC 972
..:|.|.::|||||.||:|.:.|||||:..||.|.:.:||:..|:..:|||||.||||..|::..
Human 821 VFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFA 885
Fly 973 DSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHV 1037
..||.||..||.:|.||.|:|..||||.|.:.||::||||||||:|:|:||..||||:|..::||
Human 886 IQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHV 950
Fly 1038 SNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQL---QCIKRFKDIFNT--PEQLDLPP 1097
.|||||:|.||||:|||.||:.||..|:.| :..| .|.|..:.|:|. |...:|
Human 951 VNPSECSSPERCILAYLYDLYVSCSHLRSK------FGDLFSSACSKVKQTIYNNVMPANSNL-- 1007
Fly 1098 QGYNPLLLQELFMAPRRGGKLDPHWLG-TLHESPANVYSFVSNALIAVCR-ETDNERLNDVALAC 1160
.::|..:.:....| ....::...|| .|.::.||.||||.|.|:.||. ..|..|:||:|...
Human 1008 -RWDPDFMMDFIENP-SARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFS 1070
Fly 1161 AELTASCNVLSEEWIYALQSLCSGSKSPRYPHLGG------QVDIGQLKTHNALAVFVCILVARH 1219
:||||.|.|||.||:..|::||..|. |:.| .||:..|..|::||.|:.||:||.
Human 1071 SELTACCTVLSSEWLGVLKALCCSSN-----HVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQ 1130
Fly 1220 CFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLE---IPQPGMYSVSTS 1281
||||.|.|...|||:|. :.:.|.| |||.|||:||.|:|.||:..: :||
Human 1131 CFSLEDVVQHVALPSLL-AAACGDA----DAEPGARMTCRLLLHLFRAPQACFLPQ--------- 1181
Fly 1282 PNPLHAVGNDF-SIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLASGSGTSSGG 1345
|.|..| .||.|||||||..||.:|.:.||.||||||:::.| |.:.....|........
Human 1182 -----ATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGD-AKIGNNSVSSLKNDDFT 1240
Fly 1346 LGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQ 1410
:.|....|......| ....||| .|.|:: :|.
Human 1241 MRGLRCDGNADDIWT---ASQNPKS------------------CGKSIS-------------IET 1271
Fly 1411 ISLLEFAQAVLKQICAQEHVLERCLKNAEQLC---DMIIDEMLTAKQAQRVLHMICYPEPEFNII 1472
.:|.|:|:.||:.||.||.|.|.|||..|:|| ::|:|.:|:..|||::|.:||||. .....
Human 1272 ANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPH-GIKEC 1335
Fly 1473 SELD--QRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNN-----AELNVWLDTVARAAIDVFH 1530
:|.| ||..|.|||:||.|||||.|||:||||.:|.|.:. ||:|..||.:|:|.|:||.
Human 1336 TEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQ 1400
Fly 1531 ME-----------EVVLPGAVKA---------------THKPKPSTWLVAPLIAKLTPAVQGRIL 1569
.. .:..|.::.: :...:...||||||||:|..:||||:|
Human 1401 QSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVL 1465
Fly 1570 RVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKMPLDYQPFLGLI 1634
:.||:.||...:. ||..::|:......|.|. |..||||.|:
Human 1466 KAAGEELEKGQHL-----------GSSSKKERDRQKQKSMSL-------------LSQQPFLSLV 1506
Fly 1635 LTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAI 1699
|||||||||.:|.||.||..|::|.|.::.|... .|:.:||:.:.:|||||.:||||||:.:
Human 1507 LTCLKGQDEQREGLLTSLQNQVNQILSNWREERY---QDDIKARQMMHEALQLRLNLVGGMFDTV 1568
Fly 1700 QKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD-----------DERH 1753
|:::..|||||:||.|::..|.||:..|.||||||:|||..|::.||.|| ::|.
Human 1569 QRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRA 1633
Fly 1754 YMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKIC---DIDKKQ-L 1812
||||:||||||:|:|.:.||..:||||||.||..:||.||..| :|||||||. .||||| |
Human 1634 YMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGL 1698
Fly 1813 RISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPL 1877
::|.||::|.||:.||.||||||||.|||.|:::|:.:.|||.|..|.||||.:.||.|||.:||
Human 1699 QVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPL 1763
Fly 1878 PLPPEDIEPVPEKICIKDEMKADTPSSVDQSP---SAVV---GGTGRGRGKGTTTRKRKPKN--- 1933
|||||:.|..| .|.|.|.| ||.: |.|.....|.|..||||.|:
Human 1764 PLPPEEEEEEP-------------TSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSR 1815
Fly 1934 -------------PKTPPVVNTQQQQPQ-------LAQQPQQPQ-NVQQQQLQQQQQQ------- 1970
|...|:.:.....|| |..|||||. .:|.|.|.....:
Human 1816 VDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSF 1880
Fly 1971 -QQHMQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNPNNMMQQNAMLQQQQQQQMQQMGNNPMQ 2034
..:.:|......|.:...|.|.|....:..|| .::|...:.|||||:.::|....|.|
Human 1881 VPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQ------QLIQMKLLQQQQQQRLLRQAQTRPFQ 1939
Fly 2035 QQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAPQQQQPPQPYHNQYAPHQQNMQ 2099
|.. .|..::.::... ...|.||.|.....| |..|.|...||
Human 1940 QDF--------CNSAVSLLEDFD-----NIMGQPGDQAALFAA---QARPSPQLPQY-------- 1980
Fly 2100 SNRIERPPLNANSKQALSQMLRQRQPFQQQAQQGPGGGFNPMQQQP--QASQQQPGPQQQMNPNQ 2162
|..||||..|.|......|.| |.||||.| ...::|:.
Human 1981 -------------------------PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAG-SVVLSPSY 2019
Fly 2163 MRQQQMNPQQNPQSVAAFNAMQQQPQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMG 2227
..:.......||..:.....:||||....||| ..|.:.|...:| .:.
Human 2020 NSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQ-----------------ASPYLQPLTGSQ-RLN 2066
Fly 2228 GQGMSQNPMMQQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQ 2292
.|.:.|:|: ||.|:.......:||:....:||
Human 2067 HQALQQSPL---------------------------------VGGGIDAVLTSAHPNLPSVPLPQ 2098
Fly 2293 QGMIQQQPQQQPQQQVQFQNFQNQYQQQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMG--N 2355
..|..:|||.:.||::. |.||.||...||. ..|.|..|.|:..:| .
Human 2099 DPMRPRQPQVRQQQRLL------QMQQPQQPQPQQP-----------PQPQQSSQSQSQTLGLQA 2146
Fly 2356 FNPQM----QQGNRNNPDFMAAAAVAQQQQQQ----QQQQRVVPGG 2393
..||. :||.:........||:.:|.|:| |.||.|.|.|
Human 2147 MQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYG 2192
| 
