DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(bx) and E(bx)

DIOPT Version :10

Sequence 1:NP_001261188.1 Gene:E(bx) / 44811 FlyBaseID:FBgn0000541 Length:2761 Species:Drosophila melanogaster
Sequence 2:XP_061496858.1 Gene:E(bx) / 3290113 VectorBaseID:AGAMI1_013045 Length:3297 Species:Anopheles gambiae


Alignment Length:3421 Identity:1376/3421 - (40%)
Similarity:1796/3421 - (52%) Gaps:820/3421 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGRGS----------RKRGRPPKTPNERASGRFNYQLLKKPKYL----SEGKSQPSTPSASRGI 51
            |:||.|          ::|||||||.......:|.|.|:||||||    .:|.|  |||||||..
Mosquito     1 MTGRQSNGPGGSASVGKRRGRPPKTATMERPKKFQYHLMKKPKYLCKDGQDGSS--STPSASRAS 63

  Fly    52 SPQSDEGSRSSHNNHTNRSRGSAAKRGRGRKSAVQPNTS--------SYSGRKGY---ESEYHYG 105
            ||...|.||.|    |:| |..|||..|||||..:...|        :.|.||.|   :||||||
Mosquito    64 SPHGSEESRPS----TSR-RTPAAKGTRGRKSTPRGRPSGRGRGGHNNSSARKAYSYHDSEYHYG 123

  Fly   106 SDFGDSEEDKSDNEDDMLLTPSD-DESLEVANESESEFSVCSFNQNGVGRPP----RPPSPEPVW 165
            ||||| :.||||.:||.|.:||| |:||  .:||:|:||:.| :..|.|...    :.|||:|:|
Mosquito   124 SDFGD-DSDKSDLDDDYLRSPSDSDDSL--GHESDSDFSMIS-STGGAGINGALYLKDPSPDPIW 184

  Fly   166 LQEGRQYAALDLPDSSEDLFIANTHVLRALSIYEVLRRFRHMVRLSPFRFEDLCAALACEEQSAL 230
            ||| |:...|:||:||:||.:....||:..||||::|||||.||||||||||.|||:..||||:|
Mosquito   185 LQE-REVPPLELPESSQDLLVPTDIVLKCTSIYEIIRRFRHQVRLSPFRFEDFCAAIWSEEQSSL 248

  Fly   231 LTEVHIMLLKAILREEDAQGTHFGPLDQKDTVNISLYLIDSITWPEVLRSYVESDKTFDRNVFHI 295
            |||:||||||.||||||:|.||||||||||:|||:|||||.||||||||||:|||.:.|:.|..|
Mosquito   249 LTELHIMLLKGILREEDSQQTHFGPLDQKDSVNIALYLIDFITWPEVLRSYIESDPSLDQAVLRI 313

  Fly   296 LSHTEYPYTGIDNRLEVLQFLSDQFLTSNSIRDVMLQEGPIHYDDHCRVCHRLGDLLCCETCPAV 360
            ||.|||||...::||.|||||:||||.:..:||.::||. |.||||||||||:|:||||||||||
Mosquito   314 LSTTEYPYVPAEDRLYVLQFLTDQFLITTQVRDDVMQEA-IRYDDHCRVCHRVGELLCCETCPAV 377

  Fly   361 YHLECVDPPMNDVPTEDWQCGLCRSHKVSGVVDCVLPQEKQGVLIRHDSLGVDRHGRKYWFIARR 425
            :|||||:||:.|||..||||.||:|||||||:||:..|||||:|.|.:.||.|||||||||:.||
Mosquito   378 FHLECVEPPLVDVPKGDWQCNLCKSHKVSGVIDCISMQEKQGLLSRQEMLGFDRHGRKYWFVVRR 442

  Fly   426 IFIEDQENFTCWYYSTTSKLKLLLSRLDAEELETRLHSQITER-RDEIERQMKLTETLTNEHKHT 489
            ||:|::::...|||||..:.:||||:||.:|||..|:.::.:: ||:|.|||.||||||::||.:
Mosquito   443 IFVENEDSSQVWYYSTVKQYELLLSKLDPDELEAELYQELDQKYRDDIVRQMTLTETLTSQHKGS 507

  Fly   490 KRSVIEIEQEAKNELLE------------------------------------------KEVLDE 512
            |:|..|::.:..::||:                                          ||....
Mosquito   508 KKSYFEVDNQRVSKLLDHQQDSNREGANAADTEEGSENKEAEEGAGEKGATGENGAEPGKEPSAS 572

  Fly   513 DEKDGDAKSE--SQSIEG----------------------------------------------T 529
            ||.....|.|  :|.:.|                                              |
Mosquito   573 DEAAAAVKEEDGTQQVNGGGGSKHVTRSKTGSLTPRTFNLDELKKKNPKDEAAGGGTAGSVSSTT 637

  Fly   530 KKQEECKMVTRQKSNQLTNGTLHFKLGMEQGFKNYVNQYSTNPIALNKPQRNEERDKRRHLSHKF 594
            ..|:....:||||..||:||||:||||||.|.|||||||:.:|||||||||||||||:|||||||
Mosquito   638 TAQDGIDRLTRQKVTQLSNGTLYFKLGMENGHKNYVNQYAVHPIALNKPQRNEERDKKRHLSHKF 702

  Fly   595 SLTTASDFKWIGITM-GTTDNMITTLRQTLINFESNIAASFLNINWVVNKKIWNAAVMNARRPSE 658
            |||..|:|||:|..: .|...:|||:||||:..|..:|..|::.||...:|:|..|:....||:|
Mosquito   703 SLTPVSEFKWLGGGLYATQQQIITTIRQTLLALEQAVATPFMHHNWNRLRKVWINAIGVCTRPNE 767

  Fly   659 FAVVLLLFQASLKSVVFANVWHEQLGHTTLQRITSAEREERKKLEKREKRERDDEEERNRLAFNY 723
            ||..:.:.||.|:.||||:|||||||||.:.|||.|||||:|||||||||||||||||||.|.|:
Mosquito   768 FARAMCMIQACLRGVVFASVWHEQLGHTKMYRITLAEREEKKKLEKREKRERDDEEERNRTAINF 832

  Fly   724 IKYTLGLKHQVWKQKGEEYRVHGQWGWLWLSSSRR-CGVRARRAQPLTHNRVYVHYTMGEENDVN 787
            :||:||||||||||||||||:||||.|:|:.:.|| ..|..|......|..:.|.:...::..|.
Mosquito   833 VKYSLGLKHQVWKQKGEEYRIHGQWDWIWMGNGRRKKTVPGRTTNEAAHVVLPVLHPETQQRKVQ 897

  Fly   788 EIILVDPRTQRFMQQCESSNVDGQ------VCHYLPD-QYKNVKVIED--------VTEKIKGHI 837
            ::   |.|:...:|:|.:...:.|      ...||.| ...|.|:::.        |.::....|
Mosquito   898 KL---DWRSYEALQKCRAVKTEQQHQPALAAVDYLTDIDSLNEKLLQKLHQIETFAVPQQYSTEI 959

  Fly   838 DVSKALNAP-GRTYYSKVARK-SRLDDLLDRRLKLAEVEEQMASKIPSDM-------KPLLVSSQ 893
            |||:||:.| ||..|.||.|| ..|:.||.||:.|.:.|||.. |:..:.       :|.:||..
Mosquito   960 DVSRALSTPQGRILYPKVGRKCPLLEGLLQRRMNLRDAEEQRI-KLAKERQDEGLGDEPAVVSKD 1023

  Fly   894 -----NNTANSKQTF-----LEKRLLRLTEVQAKGGP-ANVNL-----------------ELVNS 930
                 |.|..:.:..     :||:|.|:  :.::||. |..||                 |.:.|
Mosquito  1024 APSGGNTTVITVRVLPPSECIEKQLQRI--ISSRGGQVAGANLKPHVTAYQQHLRNRQYREKLQS 1086

  Fly   931 LAKQIQTVRLQFSQLNRFAKVFRCYTKECNTNSNAVSQITQNTCYSPLCLQKARAKKELLLLLR- 994
            |..|.|.:|:|:...||.....|||:..|   |.|.|..|. .|||.||.|||..|.:|..||: 
Mosquito  1087 LVNQTQELRVQYHYANRKTAQNRCYSIGC---SMANSPPTM-ACYSSLCRQKAALKAKLFALLKQ 1147

  Fly   995 ------------KAHTAGNGSKETVAAILGAVKKPSILEQKLTEGKRES-----TQVAV------ 1036
                        ::.||..|:  ..||...|....|||||||||.|:||     |..:|      
Mosquito  1148 MQLLEIQHNSTIQSATAAGGA--AAAAAAAAAPSKSILEQKLTEAKKESFENLLTNFSVNLFKSL 1210

  Fly  1037 -DDSEEGKPAESEAPLDLLQDWEHARAHAVPFSDSLLTECILVDQE--CVTNTK----------- 1087
             ||.|..|....|...:||   :...|...|..::...|.:.|.:|  .:.|..           
Mosquito  1211 NDDLERSKRTLVEYDAELL---DKLTAEVAPKLEASAEEGVTVKEEPDMLANASSSAAVLDCADV 1272

  Fly  1088 IKQEVNASSGCN------------TTP---DSNTQDSDKIDYIESMDVCSNVEIESTEDSIVTGL 1137
            :|:||..|:..|            |||   |:...|.|:.| |.:..:..|.  .|..:|:.:.:
Mosquito  1273 VKEEVVCSTEDNAMDSTAAMLDVTTTPTVEDAKPMDVDEGD-ISASGIALNE--NSNSNSLASDV 1334

  Fly  1138 NSGNAEDVDMTPGWRRKRNQKSKK------SYIGTKD----------------VLDQTLDKDIPL 1180
            ::|:...|....|...:...|:.:      :...:||                :.::.|...||:
Mosquito  1335 SNGDGSRVTRGRGRSSRLAMKASEEAAMAAATSASKDTGCANVSPVKPKEEELLPEKKLAVLIPV 1399

  Fly  1181 NKQNRRFPITARPVKRECVKKYERETFENGNERVYSTSSPRGRVYLLNDAAKLYEQAVKTEDKS- 1244
             :.||||.:.:|.||:|  :..|:|...:|:.||||.||.:||:||    .|....|||....| 
Mosquito  1400 -RPNRRFALPSRSVKKE--EAEEKEEAPDGSVRVYSVSSTKGRIYL----KKSLPPAVKPATGSG 1457

  Fly  1245 ----------TITKKP----SYSRYPLISNFLTHKK-KRSLLVLPRFELLKLARLGGKSSTNGFH 1294
                      ..|:.|    ...|||:::.|.|.|. ..|::||||.||.|||:.||:...:|||
Mosquito  1458 AAGDGGGKPKADTRIPVLGNGKPRYPVVNYFRTKKAGVSSIMVLPRGELFKLAKHGGRLPVSGFH 1522

  Fly  1295 HAAKNNT-IWQYQCSRPLFRTCWSYRTSNATSLSSLALQLRILWSCLRWDDMIAKPPSTDGKHQV 1358
            |.||.|| :|.|.||||||:|||.||:.|.||||::.|||||||:|||||||..||.:.||||||
Mosquito  1523 HLAKTNTSVWPYPCSRPLFKTCWLYRSVNLTSLSAVGLQLRILWTCLRWDDMAMKPLTADGKHQV 1587

  Fly  1359 TTDTEIVTLELLKLRHSGRYGEKTSYLRRKVVIPLEMPKTVR-EVTSIRSGLRKRKRAESPQPTE 1422
            ||::||::||||:.||.|.:.|:..|||||||||||:||||| ||.||||||||||||||||.||
Mosquito  1588 TTESEIMSLELLRHRHVGMFNERLQYLRRKVVIPLELPKTVRAEVQSIRSGLRKRKRAESPQQTE 1652

  Fly  1423 PQITEEWVDEDKLELWEIKFMGEKQEK---ARLSAVTRS-----------VASRQLEASGSNGSN 1473
            ||::|||:|||||||||||..||||||   |....|||:           .|.....||...|:.
Mosquito  1653 PQVSEEWIDEDKLELWEIKLYGEKQEKLAAASAQPVTRNSTGKLPVNNRMAADSSSSASPGGGAQ 1717

  Fly  1474 TSTNGALGVAGRVQLAPKLSED-VKEKMEQQLKLQRAVHQQRKLVATGEITR--SVTPVKGQVIG 1535
            ::.:.|.|       ..|.|.| :.|||||||:||||.|.|::.:   |:.:  |.||....|| 
Mosquito  1718 SNKSSASG-------GNKASRDEINEKMEQQLRLQRAAHNQKRAM---ELKQEGSTTPKPAGVI- 1771

  Fly  1536 SRRVIVKNPDGTTRIIQQAVTQVSRTGGANTAAAAASPTVGGSTSTQSNPSTSTPHKVQIIRGPD 1600
            .|:::|||.||||:||||.|               |:|:..|...|.:.|....|.|||||||||
Mosquito  1772 QRKILVKNADGTTKIIQQNV---------------AAPSSSGQQQTATTPKPDGPQKVQIIRGPD 1821

  Fly  1601 GKVSVRGLNPGQQLVQMPDGKLHVLTTTTSSNSAGQ-----GNKMKVPIKPASTSSSPAISSAQT 1660
            ||||||||||||||:|.||||||||  :::.||..|     ..|: |.:.|..|.|:.|.:|..|
Mosquito  1822 GKVSVRGLNPGQQLIQTPDGKLHVL--SSNPNSPKQMITKIAQKI-VKVGPTGTPSTSAATSTVT 1883

  Fly  1661 T---TNPVTPVIKQIAVKHVTKNSATQSIASSSRVALPLAQIKNKLLLAQQQQQSTSS------- 1715
            :   :||.||. :.|..|.|...:||.:..:::....|:.|:..:.||.:.|..:.::       
Mosquito  1884 SGDASNPSTPT-QHILNKGVLVRNATSTPTAAATPQQPVKQVVQRQLLQKVQTSNATTTVQNAQQ 1947

  Fly  1716 --SPAT-------------------------SSSPVQKIVSKVVNTSTSGQTLQQVFVQSGSKLV 1753
              ||||                         :|:||||:|     ||...|.||....|.|.|::
Mosquito  1948 IVSPATQKIVINNQSTLQKVITSGGHQQLLATSTPVQKVV-----TSNLQQLLQGTQHQGGQKVI 2007

  Fly  1754 VGQNA-------------------QGQKVIISTSAAQQQGTSPVQQQQLVQSQ-PIQQSPQQISM 1798
            |...|                   |.|||:::|:    .|...|.:|.|:|:. ....:||||.:
Mosquito  2008 VEPTAAAAAAAAAAANTSTAQPTLQTQKVLLATT----PGQPTVTKQILIQNAGSAGGTPQQIII 2068

  Fly  1799 TQVGNQPTQKVIQQIVNTSNVQQQIVVGGQRIILSPGQTIV-----------------------T 1840
            ...|    ||::||||  ::..|||::|||||||:.||.||                       |
Mosquito  2069 NHGG----QKMVQQIV--ASPGQQIMIGGQRIILNSGQKIVSNTPLQIQTQPAVVSMAGGGQLTT 2127

  Fly  1841 QRNVPQSQALQMV--------------QQQIQTQQQQQQHHVVQPQQQFVVQSNQIVQSSPSAQT 1891
            ...|.|.|.:|.:              |||:|.||||||....|.|||...|..|          
Mosquito  2128 TGTVQQIQKVQQIVTAAQPTIATATLQQQQLQQQQQQQQQQQQQQQQQQQQQQQQ---------- 2182

  Fly  1892 KLVKQLVVQQQSQQTIEEKTQITTTDSNETGTQQVLVPN--STLAQQLAQGKLQVATVNGQQVIV 1954
               :|...|||.|..|::...:.|..:.....||.:|.|  .:|||||:.||||:|||.||||::
Mosquito  2183 ---QQQQQQQQIQIQIQQPASMQTIAAASQQPQQTVVINQAQSLAQQLSSGKLQLATVGGQQVLL 2244

  Fly  1955 KPLGNNQAQIVAHIKHQGDGNAHIVTSNSATAVPQANPQ------TSPVKQQALPPQSPQQVVVQ 2013
            :|:.|||||:|||:|...:|.|.|:...:.|...||..|      ....:||....|..||.::|
Mosquito  2245 RPISNNQAQVVAHLKTLPNGTAQIIPVGNLTDPAQAQQQQLQQQLQQQQQQQQQQQQQQQQQLIQ 2309

  Fly  2014 QQQIHQ-------QSPTNFESGVTPITQQPVLTQAVQAPAQQQ-------ALSVEESLLQNQPPG 2064
            |.||.|       |:.::..|.|....||....|..|...|||       :.|||:||||.||||
Mosquito  2310 QHQILQPAVQQVMQTTSDINSVVLQQQQQQQQQQQQQQQQQQQQQQQQQISNSVEQSLLQGQPPG 2374

  Fly  2065 TVIKCVTAQVLQTEHGPRIVLQGLVGNDFTAQQLQLVQTQVKQQLMKAQESNGKL-GVLGPTKIY 2128
            ||||||||||:.|..|||||||||.|:|||.||..|||.||||||::.|||||:. |::||||||
Mosquito  2375 TVIKCVTAQVVHTGQGPRIVLQGLQGSDFTPQQTALVQQQVKQQLLRVQESNGRQGGMIGPTKIY 2439

  Fly  2129 LAVQP-------ENAVQSQPPPLTPV--------------HQSAAHQQ--------------VGG 2158
            ||:||       ...|.|||||||||              ||..|.::              ...
Mosquito  2440 LAIQPAQNTMATAGTVTSQPPPLTPVQIKHDGTGTPIQIHHQDNATEEGAELGMQEAGTLPNTAT 2504

  Fly  2159 GVSIAYTRMMNSNYFVQEIEEEEDYDDEIIVVCSPPNQIVPSPPREVFEGRILRSELPCRTNNNF 2223
            .:..|...:..:|.....|::.:......|::....|..|.:|        :::.||..:.:||.
Mosquito  2505 TIPAAVPMIQGTNNPSSAIDDGKPRILSNIIINGANNASVINP--------LVKKELIQKVSNNL 2561

  Fly  2224 EDQDNIEQHRLKYESEDLKRCSLQTNNI----EIDADTLATTYEANSTIKDIAINNGDDQENSKC 2284
            ..|...:|.:           .:|..|:    |.:|..:||:..|... :|.|     |:...|.
Mosquito  2562 NKQQQQQQQQ-----------KMQQQNVVPAAEPEATVVATSVVAPPQ-QDAA-----DEAKEKE 2609

  Fly  2285 AETENSNITTNESFAGTSSLLEGSEHDEPTNLAGLDISETDLENKQNESFVVTRGYIQKSISNAL 2349
            .:.|.||              ||                       .||||||..|||:.|:||.
Mosquito  2610 GDLEESN--------------EG-----------------------KESFVVTSDYIQQLINNAR 2637

  Fly  2350 KQGNLSPELEEKLVCMQKQQENANST-------------------NEWETCSRGSVNEEALTPSR 2395
            ||||..||:||||:.:|:..|....|                   |..|:.|..|...:..||..
Mosquito  2638 KQGNNPPEIEEKLLNLQRYHEKNTKTEDRSDRTIALQHNYSNMTGNRSESHSNSSRTRKRPTPRA 2702

  Fly  2396 QTDDTEWKIRTSLR-RPNAMTTS--------------SQFNRILKKN------------------ 2427
            :.||.||::.|..| ||:..|:|              |...|.|..|                  
Mosquito  2703 EDDDDEWQLDTPKRSRPSKSTSSAAGGGVSTHLSPGGSSRERKLSNNETHGSAAASSPNKRRAGA 2767

  Fly  2428 ------------------------------RSKNDE------------------VAELGEQK--- 2441
                                          |::|.|                  |:....|:   
Mosquito  2768 SSHQTQHQSPTATMIVTSSAEGKSDSPSTGRNRNAEKRKQQSSAGANCDSSGTAVSPQQHQQNPH 2832

  Fly  2442 ------QSQLERHKELLKKNILRKRSLLERNLQSEIHEDVKTKVQ-----RHVRPLSNA------ 2489
                  |:||.||||.|||:||:|||.||:.||.:|.:::..::|     .::|..|.|      
Mosquito  2833 QRQSKLQAQLNRHKEQLKKDILKKRSHLEKELQVQIQKELSVELQSASGTTNIRAASAAATGGGG 2897

  Fly  2490 -------------------------------SP----------DEQSENERSGEP---------- 2503
                                           ||          ||..|:|:...|          
Mosquito  2898 GGGGGRVMVTTAGTTAAASFQQQEQQHQQLQSPLMAESSLTNADEHEESEKLVPPGRGSSKQTTD 2962

  Fly  2504 ---------NLDFKRTEVQ------------------------------NPR----HGAGRPKKL 2525
                     ....:||.|.                              |.|    .|||:.|:.
Mosquito  2963 KSSSTASATTTSRRRTIVSGANAATKEPTGAAASAKRGQKHATPAAKSGNARSSGGRGAGQSKRG 3027

  Fly  2526 TRK--KEKLYCICRTPYDDTKFYVGCDLCSNWFHGDCVSITEEASKKLSEFICIDCKRARETQQL 2588
            .:|  |.:.:|||:|||||:|||||||||:||||||||.|:|..|||::|:||.:||.|||||:|
Mosquito  3028 AKKNNKAQTHCICQTPYDDSKFYVGCDLCNNWFHGDCVGISEAESKKITEYICSECKHARETQEL 3092

  Fly  2589 YCSCRQPYDESQFYICCDKCQDWFHGRCVGILQSEAEFIDEYVCPECQRKNDANAANMKKLTSND 2653
            ||.||||||||||||||||||||||||||||||.||..||||.||.|...|..|.||||.|::.:
Mosquito  3093 YCLCRQPYDESQFYICCDKCQDWFHGRCVGILQCEANNIDEYSCPNCHMNNAINFANMKTLSAKE 3157

  Fly  2654 VEELKNLIKQMQLHKSAWPFMEPVDPKEAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMT 2718
            .|.||.||||:|.|||||||||||||.||||||:||||||||:::|.|:::..|..|||||||||
Mosquito  3158 FENLKKLIKQIQQHKSAWPFMEPVDPNEAPDYYRVIKEPMDLQKIEGKIDNKVYQTLSEFIGDMT 3222

  Fly  2719 KIFDNCRYYNPKESSFYKCAEALESYFVQKIKNFRENVFDQ 2759
            ||||||||||||||.|::|||:|||:||||||:|||::.|:
Mosquito  3223 KIFDNCRYYNPKESPFFRCAESLESFFVQKIKHFREHLIDR 3263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(bx)NP_001261188.1 DDT 188..248 CDD:214726 43/59 (73%)
WHIM1 286..330 CDD:464774 23/43 (53%)
PHD1_BPTF 341..383 CDD:277034 32/41 (78%)
WSD 405..>441 CDD:464775 20/35 (57%)
PHD_SF 2533..2579 CDD:473978 33/45 (73%)
PHD2_3_BPTF 2589..2635 CDD:277035 40/45 (89%)
Bromo_gcn5_like 2653..2752 CDD:99941 74/98 (76%)
E(bx)XP_061496858.1 None

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