Protein Alignment E(bx) and Bptf

DIOPT Version :10

• Sequence 1: NP_001261188.1
• Gene: E(bx) / 44811
• FlyBaseID: FBgn0000541
• Length: 2761
• Species: Drosophila melanogaster
• Sequence 2: XP_038943342.1
• Gene: Bptf / 303617
• RGDID: 1307039
• Length: 3165
• Species: Rattus norvegicus
• Alignment Length: 3582
• Identity: 951/3582 - (26%)
• Similarity: 1392/3582 - (38%)
• Gaps: 1260/3582 - (35%)

  Fly     1 MSGRGSRKRGRPPKTPNERASGRFNYQLLKKPKYLSEGKSQPSTPSASRGISPQSDEGSRSSHNN 65
            |.||    ||||||.|...|:.|........|.........|..|.||..|.     |.||.|..
  Rat     1 MRGR----RGRPPKQPAAPAAERCAPAPPPPPPPPPPPPPPPPPPPASGPIG-----GLRSRHRG 56

  Fly    66 HTNRSRGSAAK------------RGRGRKSAVQPNTSSYS--------------GRKG------- 97
             ::|.|.:||:            ||.||:....|..:|.|              ||.|
  Rat    57 -SSRGRWAAAQAEVAPKTRLSSPRGGGRRKQPPPPPASASSASGPGRGGRGGGGGRTGGGGGHLA 120

  Fly    98 ----------------YES------------EYHYGSDFGDSEE---DKSDNEDDMLLTPSDDES 131
                            :||            |.....:.||:||   .:.|.||||.....|.:.
  Rat   121 RTTSARRAVNKVVYDDHESEDDDEEEDMVSEEDEEEEEDGDAEETQDSEDDEEDDMEEDDDDSDY 185

  Fly   132 LEVANESESEFSVC---SFNQNGV------GRPPRPPSPEPVWLQEGRQYAALDLPDSSEDLFIA 187
            .|...:.:.:.|.|   ||..:..      .|.||...|....|:| :....|:.|.|||||.:.
  Rat   186 PEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEE-KDIPPLEFPKSSEDLMVP 249

  Fly   188 NTHVLRALSIYEVLRRFRHMVRLSPFRFEDLCAALACEEQSALLTEVHIMLLKAILREEDAQGTH 252
            |.|::..::||||:|.|.:::|||||.|||.||||..:||..|:.|:|:.||||:|||||...|.
  Rat   250 NEHIMNVIAIYEVVRNFGNVLRLSPFCFEDFCAALVSQEQCTLMAEMHVALLKAVLREEDTSNTT 314

  Fly   253 FGPLDQKDTVNISLYLIDSITWPEVLRSYVESDKTFDRNVFHILSHTE---YPYTGIDNRLEVLQ 314
            |||.|.||:||.:||.||.:|||||||.|.||||.:    .|:|.:.|   |||..::::::|||
  Rat   315 FGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEY----HHVLPYQEAEDYPYGPVESKIKVLQ 375

  Fly   315 FLSDQFLTSNSIRDVMLQEGPIHYDDHCRVCHRLGDLLCCETCPAVYHLECVDPPMNDVPTEDWQ 379
            ||.|||||:|..|:.::.||.|.|||||||||:||||||||||.||||||||.||:.:||.::||
  Rat   376 FLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQ 440

  Fly   380 CGLCRSHKVSGVVDCVLPQEKQGVLIRHDSLGVDRHGRKYWFIARRIFI-EDQENFT---CWYYS 440
            |.:|.:|||.||.|||...:|....:||:.:|.||..|||||:.||:.| ||.||..   .||||
  Rat   441 CEVCVAHKVPGVTDCVAEVQKNKPYVRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKVWYYS 505

  Fly   441 TTSKLKLLLSRLDAEELETRLHSQITERRDEIERQMKLTETLTNEHKHTKRSVI----------- 494
            |..:|..|:..||.:..|..|...:.:.|:|:::.|.:||.|||:.:.:.:|.:
  Rat   506 TKVQLAELIDCLDKDYWEAELCRVLEDIREEMQQHMDVTEDLTNKARGSNKSFLAAANEEILDSL 570

  Fly   495 -------------------------------------EIEQEAKNELLEKEVLDEDEKDG----- 517
                                                 |.|.::.::..:.:||:|:...|
  Rat   571 RIKRGEDIDCDQNPEDTEKDKNEGENDSSKGAEKSREESEDQSPDKDADGKVLEEEPGQGKPEEP 635

  Fly   518 -------------------DAKSESQSIEGTKKQ------------------------------- 532
                               :|.||....||...:
  Rat   636 TEVGDKGNSVPANLGDNTRNASSEETPCEGRSPEGWLSETHDSSTAEKKVASELPPDVPEDSHKT 700

  Fly   533 -----------------EEC--------------------------------------------- 535
                             |.|
  Rat   701 CDSSNTSATTASSQPNLENCSSSSSSSELTSSQSDSAKAADDPDIGERDSHTPVSVQEEIGDFRL 765

  Fly   536 ---------------------KMVTR----------QKSNQLT---------------------- 547
                                 :::||          .||.|:.
  Rat   766 DKSNGEVSESPGTGKGTSGSTRIITRLRNPESKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQ 830

  Fly   548 ----------------NGTLHFKLGMEQGFKNYVNQYSTNPIALNKPQRNEERDKRRHLSHKFSL 596
                            |...:||||.|..::.|.||||||..||||.|..|:.||||||:|||.|
  Rat   831 GEVSRLSTKKEVVMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCL 895

  Fly   597 TTASDFKWIGITMGTTDNMITTLRQTLINFESNIAASFLNINWVVNKKIWNAAVMNARRPSEFAV 661
            |.|.:|||.|...|:....|:|||.|:...||||.:|||:.||..::..|..||....:|.|||:
  Rat   896 TPAGEFKWNGSVHGSKVLTISTLRLTITQLESNIPSSFLHPNWASHRANWIKAVQMCSKPREFAL 960

  Fly   662 VLLLFQASLKSVVFANVWHEQLGHTTLQRITSAEREERKKLEKREKRERDDEEERNRLAFNYIKY 726
            .|.:.:.::|.||...:|.|.||||.|.|:||.||||::|::|:||::   |||.......::||
  Rat   961 ALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQ---EEEETMQQATWVKY 1022

  Fly   727 TLGLKHQVWKQKGEEYRVHGQWGWLWLSSSRRCGVRARRAQPLTHNRVYVHY---------TMGE 782
            |..::|||||||||||||.|..||.|:|.:     ...|..|.......|:|         .|.|
  Rat  1023 TFPVRHQVWKQKGEEYRVTGYGGWSWISKT-----HVYRFLPKLPGNTNVNYRKPLEGVKNNMDE 1082

  Fly   783 ENDVNEIILVDPRTQRFMQ-QCESSNVDGQ-------------VCHYLPDQ-------------- 819
            ..|.:: ....||:.:.|: :|:|...:.:             ....||::
  Rat  1083 NKDESD-KRKSPRSPKKMKTECDSEKGEARDADSTAGATAGTMELSKLPEKEEHDVKELLDPDND 1146

  Fly   820 --YKNVKVIEDVTEKIKGH-----------IDVSKALNAPGRTYYSKVARKSRLDDLLDRRLKLA 871
              :|...:..|.:.|.:.|           ::||:..:.  ||.|.|..:.|:||.||:||::..
  Rat  1147 KPFKEEPMEIDDSVKTESHMNSEESAQVDVVNVSEGFHL--RTSYKKKTKSSKLDGLLERRIRQF 1209

  Fly   872 EVEEQM-------------ASKIP-----SDMKP-------------LLVSSQNNT--------- 896
            .:||:.             |.|.|     |..:|             ||...|.:|
  Rat  1210 TLEEKQRLEKLKLESGVKGAGKPPTGAVKSSSEPPVSTKADEGHQGDLLRQEQRSTPSQAGTADL 1274

  Fly   897 -----------------------------------------ANSKQTFLEKRL-LRLTEVQAKGG 919
                                                     |...|..:|..| .|::|..:||
  Rat  1275 GLGASQSDPLVLGISPPSLSTGKPDPKGQVLDDVSIQSPGPACQGQNSVESDLDARISEATSKG- 1338

  Fly   920 PANVNLEL------------------------------------------VNSLAKQIQTVRLQF 942
                 |||                                          |:|.:|......:..
  Rat  1339 -----LELSQTKTKVTDSLTDDSKPTSADEGSTLICKSKKPLPQDDCSTAVSSSSKSTLPAPVPK 1398

  Fly   943 SQLNRFAKVF-------------------------RCYTKECN------TNSN------------ 964
            |..:|.|:.|                         ..|.::.:      .|||
  Rat  1399 SPRDRDARAFPKAMDLDGRLGGDSEYNSTLENNSGTMYMRDSSEEDMVVQNSNDTTSKRFITPDQ 1463

  Fly   965 -----------AVSQITQNTCYSPLCLQKARAKKELLLLLRKAHTAGNGSKETVAAILGAVKKPS 1018
                       .||:.|:|      |..:.:.|.          |..||.|      ||..:||
  Rat  1464 GMESTEPTKCQLVSKSTEN------CDNRLQGKV----------TEANGKK------LGQHQKP- 1505

  Fly  1019 ILEQKLTEGKRESTQVAVDDSEEGKPAESEAPLDLLQDWEHARAHAVPFSDS------------- 1070
              |::..  .|.:.||::..|.:.|.:|:.   :..:..:.|....:...||
  Rat  1506 --EERAV--NRCADQVSLRHSADRKNSEAR---ESEKRGQKANKFQINGKDSKAKGYLKGPGMKD 1563

  Fly  1071 -----LLTECILVDQECVTN----------------TKIKQEVNASSGCNTTPDSNTQDSDKIDY 1114
                 :::..:   :..|.|                :.:|..||.........:.||.:::...
  Rat  1564 VSDGKVMSGAV---EPKVNNINKVIPGNIKSLAGKESAVKPFVNGDIIMEEFSEQNTSETNSYS- 1624

  Fly  1115 IESMDVCSNVE-----IESTEDSIVTGL----------NSGN-AEDVDMTPGWRRKRNQKS---- 1159
            :.|.|...|.:     :.||:||..|.:          ||.| .||:: |.|...|:...|
  Rat  1625 LSSSDAKGNHQDGLHTLPSTKDSASTQVIIPPAPCPDRNSLNQVEDME-TEGPEVKKVTPSPITT 1688

  Fly  1160 -KKSYIGTKDVLDQT---LDKDIPLNKQNRRFPI---------TARPVKRECVK--KYERETFEN 1209
             :.|.:| |||:|:.   ..||..:|.:::|..:         |.....:..:|  |.:::|..:
  Rat  1689 GEDSNLG-KDVMDENGLPSSKDENVNGESQRKTVITEVTTMTSTVATESKTVIKVAKGDKQTVVS 1752

  Fly  1210 GNERV--------------YSTSSPRGRVYLLNDAAKLYEQAVKTEDKSTIT------------- 1247
            ..|..              .||.||...|    |...:.||: ||...:|:|
  Rat  1753 STENCARSTVTTTTTTVTKLSTPSPDSDV----DTVSVKEQS-KTVVTTTVTDSLSTAGSTLVTS 1812

  Fly  1248 ------------------KKPSYSR----YPLISNFLTHKKKRSLLVLPRFELLKLARLGGKSST 1290
                              .:|..:|    .|....|:|...|:|:.|||..:|.||||.||....
  Rat  1813 MTVSREYSTRDRVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREV 1877

  Fly  1291 NGFHHAAKNN-TIWQYQCSRPLFRTCWSYRTSNATSLSSLALQLRILWSCLRWDDMIAK-PPSTD 1353
            ..|::.||.. .||.|...||.|...|.||.....||:.::|.||:||:.||||||.|| ||...
  Rat  1878 PCFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGG 1942

  Fly  1354 GKHQVTTDTEIVTLELLKLRHSGRYGEKTSYLRRKVVIPLEMPKTVREV-TSIRSGLR----KRK 1413
            .....|::|||.|.|::|.|..|.||.::.|..||::.|:.:|:..:|. |..|.|||    :.|
  Rat  1943 STRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPEAPKETPTPQRKGLRSSALRPK 2007

  Fly  1414 RAESPQPTEPQITEEWVDEDKLELWEIKFMGEKQEKARLSAVTRSVASRQLE-------ASGSNG 1471
            |.|:|:.|.|.:.|.||.|::||||||:...|:.||.:..||.:....| ||       |:.:..
  Rat  2008 RPETPKQTGPVVIESWVAEEELELWEIRAFAERVEKEKAQAVEQQTKKR-LEQQKPAVIAASTTS 2071

  Fly  1472 SNTSTNGALGVAGRVQLAPKLSEDVKEKMEQQLKLQRAVHQQRKLVATGEITRSVTPVKGQVIGS 1536
            ...||:..:..|.:|.:||                               ::.||||
  Rat  2072 PTNSTSSTVSPAQKVMVAP-------------------------------LSGSVTP-------- 2097

  Fly  1537 RRVIVKNPDGTTRIIQQAVTQVSRTGGANTAAAAASPTVGGSTST-----QSNPSTSTPHKVQII 1596
                     ||..::      .::.|...|.....:.....:.:|     |||.:|||
  Rat  2098 ---------GTKMVL------ATKVGSPATVTFQQNKNFHQTFATWVKQGQSNSATST------- 2140

  Fly  1597 RGPDGKVSVRGLNPGQQLVQMPDGKLHVLTTTTSSNSAGQGNKMKVPIKPASTSSSPAISSAQT- 1660
                                                              |:||::...|:.||
  Rat  2141 --------------------------------------------------AATSATTIASTGQTL 2155

  Fly  1661 --TTNPVTPVIKQIAVKHVTKNS--------ATQSIASSSRVALPLAQIKNKLL------LAQQQ 1709
              |.:|||...|.|....:..||        |||.         .:.|::.|:|      ....|
  Rat  2156 HITGSPVTMAGKVITKLPLPANSKIVAVNVPATQG---------GVVQVQQKVLGIIPSTAGPSQ 2211

  Fly  1710 QQSTSSSPATSSSPVQKIVSKVVNTSTSGQT----------------LQQ-----------VFVQ 1747
            |..||..|.|::..::...|....|:|:.|.                |||           |.:|
  Rat  2212 QTFTSFQPRTATVTIRPNTSASAGTTTTSQVITGPQIRPGMTVIRAPLQQPALGKAVIRTPVTMQ 2276

  Fly  1748 SGS-KLVVGQNAQGQKVIISTSAAQQQGTSPVQQ--------QQLVQSQPIQQSPQQ----ISMT 1799
            .|: :.||.|..:||.|..:.||:....::|||:        ..|..|.|....|||    ::|.
  Rat  2277 PGAPQQVVTQIIRGQPVSTAISASSTASSAPVQKGLTPGAAAGTLQPSAPHSPRPQQGQVKLTMA 2341

  Fly  1800 QV--------GNQPTQKVIQQIVNTSNVQQQIVVGGQRIILSPGQTIVTQRNVPQSQALQMVQQQ 1856
            |:        |||....|||....|:. |.|::..|..::..|||.:: |..:|.....:.:...
  Rat  2342 QLTQLTQGHGGNQGLTVVIQGQGQTTG-QLQLIPQGMTVLPGPGQQLM-QAAMPNGTVQRFLFTP 2404

  Fly  1857 IQTQQQQQQHHVVQPQQQFVVQSNQIVQSSPSAQTKLVKQLVVQQQSQQTIEEKTQI--TTTDSN 1919
            :.|..                   ..|.||.|:.:.........:|.|..:..:||:  .||
  Rat  2405 LSTPV-------------------TAVSSSSSSSSTNATATGSGEQKQSKLSPQTQVQPATT--- 2447

  Fly  1920 ETGTQQVLVPNSTLAQQLAQGKLQVATVNGQQVIVKPLGNNQAQIVAHIKHQGDGNAHI------ 1978
                   |.|..:.:...|:.:.|.|     |...:|....|......::.|...::|:
  Rat  2448 -------LAPTQSSSVSPAEAQPQPA-----QPAAQPQPQPQPPAQPEVQTQPAASSHVPSETQP 2500

  Fly  1979 --VTSNSATAVPQANPQT-----SPVKQQALP-----PQSPQQVVVQQQQIHQQSPTNFESGVTP 2031
              ..|:......|..||:     |||:.|:.|     |.:|.||...||...|.:.:.      |
  Rat  2501 SQAQSSKPLVATQCQPQSSVQGQSPVRVQSPPLTRIRPSTPSQVTPGQQPQVQTTASQ------P 2559

  Fly  2032 ITQQPVLTQAVQAPAQQQALSVE--ESLLQNQPPGTVIKCVTA--------QVLQTEHGPRIVLQ 2086
            |...|  ..::|||:|.|..|..  :|..|....|..:..||.        |..|.:  |:::
  Rat  2560 IPIPP--PTSLQAPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVPSPSRPQPQTQQPQ--PQVI-- 2618

  Fly  2087 GLVGNDFTAQQLQLVQ--TQVKQQL---MKAQESNGKLGVLGPTKIYLA----VQPENAVQSQPP 2142
                   ...|||.||  :|::.|:   ::||:..      .|.:|.|.    ||..:|.|:|
  Rat  2619 -------AVPQLQQVQVLSQIQSQVVAQIQAQQGG------APQQIKLQLPVHVQQNSAAQAQ-- 2668

  Fly  2143 PLTPVHQSAAHQQVGGGVSIAYTRMMNSNYFVQEIEEEEDYDDEIIVVCSPPNQIVPSPPREVFE 2207
                      |.|     |:...:..:....:|.:::
  Rat  2669 ----------HAQ-----SVLTVQAASVREQLQRVQQ---------------------------- 2690

  Fly  2208 GRILRSELPCRTNNNFEDQDNIEQHRLKYESEDLKRCSLQTNNIEIDADTLATTYEANSTIKDIA 2272
                           ..||...::.:::.|.|...:.|.|:..|:                |.:.
  Rat  2691 ---------------LRDQQQKKKQQIEMEREHTLQASNQSEIIQ----------------KQVV 2724

  Fly  2273 INNGDDQENSKCAETENSNITTNESFAGTSSLLEGSEHDEPTNLAGLDISETDLENKQNESFVVT 2337
            :.:....|:.|..:|                                   .|..|.::|:..:|.
  Rat  2725 MKHNAVIEHLKQKKT-----------------------------------MTPAEREENQRMIVC 2754

  Fly  2338 RGYIQKSISNALKQGNLSPELEEKLVCMQKQQENANSTNEWETCSRGSVNEEALTPSRQTDDTEW 2402
             ..:.|.|.:.:       :.|||....::::                  ||::...|.
  Rat  2755 -NQVMKYILDKI-------DKEEKQAAKKRKR------------------EESVEQKRS------ 2787

  Fly  2403 KIRTSLRRPNAMTTSSQFNRILKKNRSKNDEVAELGEQKQSQLERHKELLKKNILRKRSLLERNL 2467
                                  |:|.||          ..:.|.:|||.||..||:||:||::.|
  Rat  2788 ----------------------KQNASK----------LSALLFKHKEQLKAEILKKRALLDKEL 2820

  Fly  2468 QSEIHE----DVKTKVQRHV-------------------------RPLSNASPDEQSENERS--- 2500
            |.::.|    |:|.|.:|.:                         .|.:..:|.....:..|
  Rat  2821 QMQVQEELKRDLKMKREREMAQVVQANAAAGPTPSVPAPVPAPAPAPAAPPAPPSPPPSTHSLPP 2885

  Fly  2501 -GEPNLDFKRTEVQNPRH----GAGRPKKL-------TRKKEKLYCICRTPYDDTKFYVGCDLCS 2553
             |.|......|..:..|.    ...:.||:       .:|..:|||||:||||::|||:|||||:
  Rat  2886 AGHPTAPLPVTSQKRKREEEKDSKSKKKKMISTTSKEAKKDTRLYCICKTPYDESKFYIGCDLCT 2950

  Fly  2554 NWFHGDCVSITEEASKKLSEFICIDCKRARE--TQQLYCSCRQPYDESQFYICCDKCQDWFHGRC 2616
            ||:|||||.|||:.:||:..:||.|||||:|  :::|||.||.|||||||||.||:||:||||||
  Rat  2951 NWYHGDCVGITEKEAKKMDVYICNDCKRAQEGSSEELYCICRTPYDESQFYIGCDRCQNWFHGRC 3015

  Fly  2617 VGILQSEAEFIDEYVCPECQRKNDANAANMKKLTSNDVEELKNLIKQMQLHKSAWPFMEPVDPKE 2681
            |||||||||.|||||||:||...||... :..||..|.|.||.:::.:|.||.||||:|||||.:
  Rat  3016 VGILQSEAELIDEYVCPQCQSTEDAMTV-LTPLTEKDYEGLKRVLRSLQAHKMAWPFLEPVDPND 3079

  Fly  2682 APDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMTKIFDNCRYYNPKESSFYKCAEALESYFV 2746
            |||||.||||||||..||.:::...|.||:||:.||||||||||||||.:|.||:|||.|||:||
  Rat  3080 APDYYGVIKEPMDLATMEERIQKRYYEKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFFV 3144

  Fly  2747 QKIKNFR 2753
            ||:|.|:
  Rat  3145 QKLKGFK 3151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	188..248	CDD:214726	33/59 (56%)
		WHIM1	286..330	CDD:464774	19/46 (41%)
		PHD1_BPTF	341..383	CDD:277034	31/41 (76%)
		WSD	405..>441	CDD:464775	20/39 (51%)
		PHD_SF	2533..2579	CDD:473978	30/45 (67%)
		PHD2_3_BPTF	2589..2635	CDD:277035	39/45 (87%)
		Bromo_gcn5_like	2653..2752	CDD:99941	64/98 (65%)
Bptf	XP_038943342.1	DDT	250..309	CDD:214726	32/58 (55%)
		PHD1_BPTF	402..444	CDD:277034	31/41 (76%)
		WSD	466..534	CDD:464775	28/67 (42%)
		PHA03169	574..>759	CDD:223003	13/184 (7%)
		SP1-4_N	2173..2569	CDD:425404	98/448 (22%)
		Atrophin-1	2385..>2567	CDD:460830	43/224 (19%)
		TPH	<2703..>2839	CDD:464007	43/250 (17%)
		PHD2_3_BPTF	2930..2976	CDD:277035	30/45 (67%)
		PHD2_3_BPTF	2988..3034	CDD:277035	39/45 (87%)
		Bromo_gcn5_like	3050..3150	CDD:99941	64/99 (65%)