DRSC/TRiP Functional Genomics Resources

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Protein Alignment nerfin-1 and INSM1

DIOPT Version :10

Sequence 1:NP_524783.1 Gene:nerfin-1 / 44786 FlyBaseID:FBgn0028999 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_002187.1 Gene:INSM1 / 3642 HGNCID:6090 Length:510 Species:Homo sapiens


Alignment Length:477 Identity:131/477 - (27%)
Similarity:177/477 - (37%) Gaps:161/477 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TPIPIPAPAEPIEKLSH--------------PHSIGIQLQHKGMPHGLGLLTTVASLPP------ 50
            :|:|.|.|..|..:.:|              |...|.:..|.|.|.........:...|      
Human    47 SPVPGPLPPPPPAERAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHE 111

  Fly    51 --KYRSRYLNLKTRCEIPLDLTLKLPSPL-----------------------PSSDVPMAATFAE 90
              ||..|..||.:    |:... ..|:|.                       |....|.......
Human   112 KHKYFERSFNLGS----PVSAE-SFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGT 171

  Fly    91 VYSENTSASSSEVQGEVTKVEELPVKPPTPPQS---PAGKRKLSRESYDDEPAKMAKKEEEVPVE 152
            .:|....|:.....|           ||.||.:   |.|||.                    |..
Human   172 AFSAGAEAARGPGPG-----------PPLPPAAALRPPGKRP--------------------PPP 205

  Fly   153 TVESTPAKPVKVAESAPKTNKASTSSGKPSRNKATRKLKF-DEETSSPVSGTVIRPLEDITDGSM 216
            |....|||.||    ||...|.          ||.|||.| ||.|:|||.|..|:      :|.:
Human   206 TAAEPPAKAVK----APGAKKP----------KAIRKLHFEDEVTTSPVLGLKIK------EGPV 250

  Fly   217 QYSNGDIDPKYNIVEITEETKAELAAIKNVIGDYVCRLCKIKFEDAFGLARHRCACIVLLEYRCP 281
            :...|               :|..||  ..:|:::|:|||.::.|.|.||:|:|:.||.:|||||
Human   251 EAPRG---------------RAGGAA--RPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCP 298

  Fly   282 ECGKQFNCPANLASHRRWHKPR-----------KEASKKENR------NTTNQPEKQQQVEKKSE 329
            ||.|.|:|||||||||||||||           :.|::.|.|      :..:.|......|..||
Human   299 ECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSESGSE 363

  Fly   330 EELAFDCQECGKKFKRAAYLRKHQLTHQKK--------EKPAEKQLEMKPTTTTITGSFHFNQAV 386
            :.| ::|..|.|||:|.||||||.|.|.:.        ..|||..|.:.|             ..
Human   364 DGL-YECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYP-------------GP 414

  Fly   387 STSSSASSSHSDEGVYVVGSNA 408
            ...:...::...||..|:|.:|
Human   415 DEKAPQEAAGDGEGAGVLGLSA 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nerfin-1NP_524783.1 C2H2 Zn finger 252..272 CDD:275368 10/19 (53%)
C2H2 Zn finger 280..300 CDD:275368 16/19 (84%)
zf-C2H2 334..356 CDD:395048 13/21 (62%)
C2H2 Zn finger 336..356 CDD:275368 13/19 (68%)
INSM1NP_002187.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..110 12/62 (19%)
SNAG domain. /evidence=ECO:0000250|UniProtKB:Q63ZV0 1..20
Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:23721412 2..7
Necessary for interaction with CCND1 43..58 4/10 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..226 21/94 (22%)
C2H2 Zn finger 269..289 CDD:275368 10/19 (53%)
C2H2 Zn finger 297..317 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..362 11/46 (24%)
zf-C2H2 367..389 CDD:395048 13/21 (62%)
C2H2 Zn finger 369..389 CDD:275368 13/19 (68%)
C2H2 Zn finger 443..464 CDD:275368
C2H2 Zn finger 471..492 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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