Protein Alignment Adk3 and ADK

DIOPT Version :10

• Sequence 1: NP_651995.1
• Gene: Adk3 / 44750
• FlyBaseID: FBgn0026602
• Length: 366
• Species: Drosophila melanogaster
• Sequence 2: NP_006712.2
• Gene: ADK / 132
• HGNCID: 257
• Length: 362
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 94/350 - (26%)
• Similarity: 160/350 - (45%)
• Gaps: 27/350 - (7%)

  Fly    29 RKVICF--GNVLLDRLVQLEDPQLLERFGLELGSKGELDMEKLNQLAAEASESSRCLTNPGGSAL 91
            |:.|.|  ||.||| :..:.|...|:::.|:...: .|..:|..:|..|..:..:...:.|||..
Human    22 RENILFGMGNPLLD-ISAVVDKDFLDKYSLKPNDQ-ILAEDKHKELFDELVKKFKVEYHAGGSTQ 84

  Fly    92 NTARI----LKQLGTDALFFGAVGADKHAEELRQIIRDRGIEARLQTVEDAHTGQCVCLMYQDNP 152
            |:.::    ::|....|.|||.:|.||..|.|::...:..::|......:..||.|...:..||.
Human    85 NSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNR 149

  Fly   153 TLYANIGASAQFEVQTLSHAVSHEGQSFLRPVERKQILYVEGFFVPQRSDVCDYIVQHLVRERRR 217
            :|.||:.|:..::.:  .| :..|....|  ||:.::.|:.|||:....:....:..|.....|.
Human   150 SLIANLAAANCYKKE--KH-LDLEKNWML--VEKARVCYIAGFFLTVSPESVLKVAHHASENNRI 209

  Fly   218 LALNLSAPYIVRKNHQAMMKLARAAFFLFGNRQEFEALAEAAG-GFRNVDELADHL-----LQSG 276
            ..||||||:|.:...:::||:......||||..|....|...| ..:::.|:|...     :.|.
Human   210 FTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSK 274

  Fly   277 GTKVIFVTNGSAGVQVITNYVEELAPPGPVSFEDFRAQRVEQLVDATGAGDAFVAGFLHAWLEKR 341
            ..:::..|.|.....:.|.        ..|:......|..::::|..|||||||.|||...:..:
Human   275 RQRIVIFTQGRDDTIMATE--------SEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDK 331

  Fly   342 SLGECIRMASSVAAKVVTQVGCNLP 366
            .|.||||.....|:.::.:.||..|
Human   332 PLTECIRAGHYAASIIIRRTGCTFP 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adk3	NP_651995.1	adenosine_kinase	28..366	CDD:238573	93/348 (27%)
ADK	NP_006712.2	Nuclear localization signal. /evidence=ECO:0000269|PubMed:19635462	8..16
		ribokinase_pfkB_like	29..361	CDD:469648	90/342 (26%)