DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ady43A and ADK

DIOPT Version :9

Sequence 1:	NP_651995.1	Gene:	Ady43A / 44750	FlyBaseID:	FBgn0026602	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_006712.2	Gene:	ADK / 132	HGNCID:	257	Length:	362	Species:	Homo sapiens

Alignment Length:	350	Identity:	94/350 - (26%)
Similarity:	160/350 - (45%)	Gaps:	27/350 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RKVICF--GNVLLDRLVQLEDPQLLERFGLELGSKGELDMEKLNQLAAEASESSRCLTNPGGSAL 91
            |:.|.|  ||.||| :..:.|...|:::.|:...: .|..:|..:|..|..:..:...:.|||..
Human    22 RENILFGMGNPLLD-ISAVVDKDFLDKYSLKPNDQ-ILAEDKHKELFDELVKKFKVEYHAGGSTQ 84

  Fly    92 NTARI----LKQLGTDALFFGAVGADKHAEELRQIIRDRGIEARLQTVEDAHTGQCVCLMYQDNP 152
            |:.::    ::|....|.|||.:|.||..|.|::...:..::|......:..||.|...:..||.
Human    85 NSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNR 149

  Fly   153 TLYANIGASAQFEVQTLSHAVSHEGQSFLRPVERKQILYVEGFFVPQRSDVCDYIVQHLVRERRR 217
            :|.||:.|:..::.:  .| :..|....|  ||:.::.|:.|||:....:....:..|.....|.
Human   150 SLIANLAAANCYKKE--KH-LDLEKNWML--VEKARVCYIAGFFLTVSPESVLKVAHHASENNRI 209

  Fly   218 LALNLSAPYIVRKNHQAMMKLARAAFFLFGNRQEFEALAEAAG-GFRNVDELADHL-----LQSG 276
            ..||||||:|.:...:::||:......||||..|....|...| ..:::.|:|...     :.|.
Human   210 FTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSK 274

  Fly   277 GTKVIFVTNGSAGVQVITNYVEELAPPGPVSFEDFRAQRVEQLVDATGAGDAFVAGFLHAWLEKR 341
            ..:::..|.|.....:.|.        ..|:......|..::::|..|||||||.|||...:..:
Human   275 RQRIVIFTQGRDDTIMATE--------SEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDK 331

  Fly   342 SLGECIRMASSVAAKVVTQVGCNLP 366
            .|.||||.....|:.::.:.||..|
Human   332 PLTECIRAGHYAASIIIRRTGCTFP 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ady43A	NP_651995.1	adenosine_kinase	28..366	CDD:238573	93/348 (27%)
Ady43A	NP_651995.1	PTZ00247	28..366	CDD:240328	93/348 (27%)
ADK	NP_006712.2	Nuclear localization signal. /evidence=ECO:0000269\|PubMed:19635462	8..16
ADK	NP_006712.2	ribokinase_pfkB_like	29..361	CDD:412208	90/342 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S836
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1226324at2759
OrthoFinder	1	1.000	-	-		FOG0003751
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100649
Panther	1	1.100	-	-	LDO	PTHR45769
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2162
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870