DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ady43A and Adk

DIOPT Version :9

Sequence 1:	NP_651995.1	Gene:	Ady43A / 44750	FlyBaseID:	FBgn0026602	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_598840.1	Gene:	Adk / 11534	MGIID:	87930	Length:	361	Species:	Mus musculus

Alignment Length:	342	Identity:	92/342 - (26%)
Similarity:	154/342 - (45%)	Gaps:	25/342 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GNVLLDRLVQLEDPQLLERFGLELGSKGELDMEKLNQLAAEASESSRCLTNPGGSALNTARILKQ 99
            ||.||| :..:.|...|:::.|:...: .|..:|..:|..|..:..:...:.|||..|:.::.:.
Mouse    29 GNPLLD-ISAVVDKDFLDKYSLKPNDQ-ILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQW 91

  Fly   100 LGTD----ALFFGAVGADKHAEELRQIIRDRGIEARLQTVEDAHTGQCVCLMYQDNPTLYANIGA 160
            |..:    |.|||.:|.||..|.|::...|..::|......:..||.|...:...|.:|.||:.|
Mouse    92 LIQEPHKAATFFGCIGIDKFGEILKRKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAA 156

  Fly   161 SAQFEVQTLSHAVSHEGQSFLRPVERKQILYVEGFFVPQRSDVCDYIVQHLVRERRRLALNLSAP 225
            :..::.:  .| :..|....|  ||:.::.|:.|||:....:....:.::.....|...||||||
Mouse   157 ANCYKKE--KH-LDLERNWVL--VEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAP 216

  Fly   226 YIVRKNHQAMMKLARAAFFLFGNRQEFEALAEAAG-GFRNVDELADHL-----LQSGGTKVIFVT 284
            :|.:...:|:|.:......||||..|....|...| ..:::.|:|...     :.|...:.:..|
Mouse   217 FISQFFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFT 281

  Fly   285 NGSAGVQVITNYVEELAPPGPVSFEDFRAQRVEQLVDATGAGDAFVAGFLHAWLEKRSLGECIRM 349
            .|.....|        |....|:......|..|:::|..|||||||.|||...:..:.|.||||.
Mouse   282 QGRDDTIV--------AAENDVTAFPVLDQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRA 338

  Fly   350 ASSVAAKVVTQVGCNLP 366
            ....|:.::.:.||..|
Mouse   339 GHYAASVIIRRTGCTFP 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ady43A	NP_651995.1	adenosine_kinase	28..366	CDD:238573	91/340 (27%)
Ady43A	NP_651995.1	PTZ00247	28..366	CDD:240328	91/340 (27%)
Adk	NP_598840.1	Nuclear localization signal. /evidence=ECO:0000250	7..15
Adk	NP_598840.1	ribokinase_pfkB_like	28..360	CDD:320807	92/342 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S836
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003751
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100649
Panther	1	1.100	-	-	LDO	PTHR45769
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2162
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.720