DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NiPp1 and Ppp1r8

DIOPT Version :9

Sequence 1:	NP_611177.1	Gene:	NiPp1 / 44748	FlyBaseID:	FBgn0026402	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001101381.1	Gene:	Ppp1r8 / 313030	RGDID:	1306280	Length:	351	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	178/380 - (46%)
Similarity:	227/380 - (59%)	Gaps:	54/380 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YDIPSWAGKPPTGLHLDVLKDDKLVQKLMVDEKRCYLFGRNSQMNDFCIDHASCSRVHSAFVYHK 69
            :|.|:||||||.||||||:|.|||::||::|||:.||||||..:.||.|||.||||||:|.||||
  Rat    14 FDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHK 78

  Fly    70 HLNIAYLVDLGSTHGTFIGTLRLEAHKPTQLQINSTFHFGASTRNYILRERPSGHHSNIMEDLPL 134
            ||...:|:||.||||||:|.:|||.|||.|:.|:||..||||||.|.|||:|....|.:..|..:
  Rat    79 HLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKM 143

  Fly   135 SETSD--GALLGLPESQTELDNLTEYNTAHNRRISMLGIDDDTNMRKQNALKQGRRTRNVTFNDE 197
            ....|  ..||||||.:||||||||:|||||:|||.|.|::. |:..|.. |:.|:...|||:|:
  Rat   144 GGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEG-NLDIQRP-KRKRKNSRVTFSDD 206

  Fly   198 EIVINPEDVDPNVGRFRNLVQTTVVPAKRARCDVNHMGIHSGNSSLSSANAAHVHQMFQQSLVDM 262
            :.:||||||||:||||||:|||.|||.|:.|.:      .||:..|..:.:..: |.|..|
  Rat   207 DEIINPEDVDPSVGRFRNMVQTAVVPVKKKRME------GSGSLGLEESGSRRM-QNFAFS---- 260

  Fly   263 KQQHREMPPPNAVLHSPTNSLYQGLPAEMHGKGDLEP--ISPLSIGSKLGLLLPNPAPEV--LPV 323
                              ..||.||| ..|.:...:|  |...::...|.:..||.||:|  .||
  Rat   261 ------------------GGLYGGLP-PTHSEPGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPV 306

  Fly   324 YDEAVETSTLAQKLAVANANVRRFGEDPHDSSGEGDSLCPQKKKYAKEAWPGRKP 378
            ...|| |.......||.|.          ::..|     |:|||||||||||:||
  Rat   307 VPSAV-TINPTPNPAVYNP----------EAVNE-----PKKKKYAKEAWPGKKP 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NiPp1	NP_611177.1	FHA	18..110	CDD:238017	59/91 (65%)
NiPp1	NP_611177.1	FHA	<40..>87	CDD:224630	32/46 (70%)
Ppp1r8	NP_001101381.1	FHA	27..119	CDD:238017	59/91 (65%)
		FHA	<41..151	CDD:224630	62/109 (57%)
		WASH_WAHD	<98..>212	CDD:288773	57/115 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348354
Domainoid	1	1.000	139	1.000	Domainoid score	I4678
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8555
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2692
OMA	1	1.010	-	-		QHG49326
OrthoDB	1	1.010	-	-		D400304at33208
OrthoFinder	1	1.000	-	-		FOG0005513
OrthoInspector	1	1.000	-	-		oto96999
orthoMCL	1	0.900	-	-		OOG6_106306
Panther	1	1.100	-	-	LDO	PTHR23308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3930
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910