DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NiPp1 and Ppp1r8

DIOPT Version :9

Sequence 1:	NP_611177.1	Gene:	NiPp1 / 44748	FlyBaseID:	FBgn0026402	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001342127.1	Gene:	Ppp1r8 / 100336	MGIID:	2140494	Length:	377	Species:	Mus musculus

Alignment Length:	373	Identity:	175/373 - (46%)
Similarity:	223/373 - (59%)	Gaps:	52/373 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AGKPPTGLHLDVLKDDKLVQKLMVDEKRCYLFGRNSQMNDFCIDHASCSRVHSAFVYHKHLNIAY 75
            |||||.||||||:|.|||::||::|||:.||||||..:.||.|||.||||||:|.||||||...:
Mouse    46 AGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVF 110

  Fly    76 LVDLGSTHGTFIGTLRLEAHKPTQLQINSTFHFGASTRNYILRERPSGHHSNIMEDLPLSETSD- 139
            |:||.||||||:|.:|||.|||.|:.|:||..||||||.|.|||:|....|.:..|..:....|
Mouse   111 LIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDE 175

  Fly   140 -GALLGLPESQTELDNLTEYNTAHNRRISMLGIDDDTNMRKQNALKQGRRTRNVTFNDEEIVINP 203
             ..||||||.:||||||||:|||||:|||.|.|::. |:..|.. |:.|:...|||::::.:|||
Mouse   176 LKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEG-NLDIQRP-KRKRKNSRVTFSEDDEIINP 238

  Fly   204 EDVDPNVGRFRNLVQTTVVPAKRARCDVNHMGIHSGNSSLSSANAAHVHQM-FQQSLVDMKQQHR 267
            |||||:||||||:|||.|||.|:.|.:      .||:..|..:.:..:... |...|      :.
Mouse   239 EDVDPSVGRFRNMVQTAVVPVKKKRME------GSGSLGLEESGSRRMQNFAFSGGL------YG 291

  Fly   268 EMPPPNAVLHSPTNSLYQGLPAEMHGKGDLEPISPLSIGSKLGLLLPNPAPEV--LPVYDEAVET 330
            .:||    .||.|.|...|:    ||..        .||. |.:..||.||:|  .||...||..
Mouse   292 GLPP----THSETGSQPHGI----HGTA--------LIGG-LPMPYPNLAPDVDLTPVVPSAVAI 339

  Fly   331 STLAQKLAVANANVRRFGEDPHDSSGEGDSLCPQKKKYAKEAWPGRKP 378
            :..... ||.|.          ::..|     |:|||||||||||:||
Mouse   340 NPTPNP-AVYNP----------EAVNE-----PKKKKYAKEAWPGKKP 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NiPp1	NP_611177.1	FHA	18..110	CDD:238017	59/91 (65%)
NiPp1	NP_611177.1	FHA	<40..>87	CDD:224630	32/46 (70%)
Ppp1r8	NP_001342127.1	FHA	53..145	CDD:238017	59/91 (65%)
Ppp1r8	NP_001342127.1	WASH_WAHD	<124..>238	CDD:314769	56/115 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844886
Domainoid	1	1.000	138	1.000	Domainoid score	I4839
eggNOG	1	0.900	-	-		E1_KOG1880
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8555
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2778
Isobase	1	0.950	-	0	Normalized mean entropy	S4121
OMA	1	1.010	-	-		QHG49326
OrthoDB	1	1.010	-	-		D955935at2759
OrthoFinder	1	1.000	-	-		FOG0005513
OrthoInspector	1	1.000	-	-		oto93459
orthoMCL	1	0.900	-	-		OOG6_106306
Panther	1	1.100	-	-	LDO	PTHR23308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3572
SonicParanoid	1	1.000	-	-		X3930
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750