Protein Alignment Cnx99A and Clgn

DIOPT Version :10

• Sequence 1: NP_477157.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001421530.1
• Gene: Clgn / 685504
• RGDID: 1592643
• Length: 612
• Species: Rattus norvegicus
• Alignment Length: 621
• Identity: 281/621 - (45%)
• Similarity: 377/621 - (60%)
• Gaps: 46/621 - (7%)

  Fly    13 LALLFASSLLLLSAANAADLDTESDDFEDGYVE-DVQEEPAVIGGDEKLAYESPVIDAKKFHFAD 76
            |.|||     :.:.|:..|...|.:||.:...| |.::||:  .|..|.....|:   .:.:|.:
  Rat    10 LGLLF-----ITAKADFVDDGVEVEDFSESSDESDFKDEPS--SGTIKYKTPQPI---GEVYFTE 64

  Fly    77 HFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAPLR 141
            .||....|  .||||:|||||:..|||.|||.|..|..:......|.||||||||||.||:|.|.
  Rat    65 TFDSGNLS--GWVLSKAKKDDMDSEISIYDGRWEIEELKENQVPGDRGLVLKSKAKHHAISAVLE 127

  Fly   142 KPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQ--LKAFNDKTPYTIMFGPDKCGND 204
            |||.| :||||:|||||..|:|.:|||:|:|||:   ||..  |:.|.|||.|||||||||||.|
  Rat   128 KPFIF-ADKPLIVQYEVNFQDGIDCGGAYVKLLA---DTGDLILENFYDKTSYTIMFGPDKCGED 188

  Fly   205 VKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSL 269
            .|:|.||||.:|..|...|||...|...|:|.|.|:..|||.||:.||::|||.:|.|::|:|:|
  Rat   189 YKLHLIFRHKHPKTGVFEEKHAKPPDVDLKEFFTDRKTHLYTLVMNPDDTFEILIDQKVVNQGTL 253

  Fly   270 LTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDE 334
            |.|..||:|||.|||||||.|||.||:|.|||||||.|||||||..|.|:.|..||.|:|||:||
  Rat   254 LEDVVPPINPPREIDDPNDRKPEEWDDRAKIPDPTAVKPEDWDEKEPIQIEDPSAVKPDGWLDDE 318

  Fly   335 PDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPN 399
            |..|.:|.|.|||||...:|||||||.:.||.|:  .|||:||.|:|.||.|||.||.|||.|||
  Rat   319 PKFIPNPKAEKPEDWSDSMDGEWEAPHIPNPACQ--IGCGEWKPPMIDNPKYKGIWRPPMINNPN 381

  Fly   400 YQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDI 464
            |||.|:|:||||||:|||..||.:|..||:|||||||:.||.|||.||..:.|||..:||:.:::
  Rat   382 YQGIWSPQKIPNPDYFEDDHPFLLTSFSALGLELWSMTPDIYFDNFIICSEKEVADQWAADGWEL 446

  Fly   465 KRRYIDRESDSFVNKVVELAKANPSIWGIGLV-AIVALVALTIYC--RFGTAKSQDSAAKKA--- 523
            |....:......:.::...|:..|.:|.:.|| |.:.:..:|.:|  |....|.:|...|||
  Rat   447 KIMVANANEPGVLRQLTTAAEERPWLWLMYLVMAGLPIALVTSFCWPRKVKKKYEDIGPKKADLC 511

  Fly   524 --AAEAKKSDDPQPDDEPEAEEE-SDERAAGDTS---KESTPLSASPKKNQKSD---LDDNEEES 579
              .::|....:|:.:..||..|: .:|:...:|.   .|...:...|::..:.|   ::..||.:
  Rat   512 QLPSKAALEQEPEEEKAPEKPEDLQEEKKPSETEVVIVEKEEVIGEPEEKSEEDAETIEGQEEMT 576

  Fly   580 KAAESREPAQTEESNTKT----------RKRQARKE 605
            |.::|....:.::::..|          |||:.||:
  Rat   577 KLSKSGSEDEMKDADESTGSGDAPVKSLRKRRVRKD 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_477157.1	Calreticulin	74..447	CDD:459737	223/374 (60%)
Clgn	NP_001421530.1	Calreticulin	62..429	CDD:459737	223/374 (60%)