DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cnx99A and Calr

DIOPT Version :10

Sequence 1:NP_477157.1 Gene:Cnx99A / 44643 FlyBaseID:FBgn0015622 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_071794.1 Gene:Calr / 64202 RGDID:620288 Length:416 Species:Rattus norvegicus


Alignment Length:556 Identity:163/556 - (29%)
Similarity:235/556 - (42%) Gaps:164/556 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 LAYESPVIDAKKFHFADHFDDVEESRKRWVLSQAKKD--DIAEEISKYDGIWNWESPQRIVWAND 122
            ||...|.|     :|.:.|.|.:....|||.|:.|.|  .......|:.|...          .|
  Rat    14 LAAADPAI-----YFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDQE----------KD 63

  Fly   123 LGLVLKSKAKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFN 187
            .||.....|:..|::|.. :||..|. :.||||:.|..::..:|||.|:||...|.|.   |..:
  Rat    64 KGLQTSQDARFYALSARF-EPFSNKG-QTLVVQFTVKHEQNIDCGGGYVKLFPGGLDQ---KDMH 123

  Fly   188 DKTPYTIMFGPDKCG-NDVKMHFIFRHVNPINGTITEKHCNKPKN-------RLEEPFKDKLPHL 244
            ..:.|.||||||.|| ...|:|.||.:              |.||       |.::   |:..||
  Rat   124 GDSEYNIMFGPDICGPGTKKVHVIFNY--------------KGKNVLINKDIRCKD---DEFTHL 171

  Fly   245 YQLVVRPDNSFEIRVDHKIINEGSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPE 309
            |.|:|||||::|:::|:..:..|||..|:  ...||.:|.||:..|||.||||.||.|||..|||
  Rat   172 YTLIVRPDNTYEVKIDNSQVESGSLEDDW--DFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPE 234

  Fly   310 DWDEDAPPQLPDTDAVMPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCG 374
            ||                     |:|:.|.||.|.||||||.|:|||||                
  Rat   235 DW---------------------DKPEHIPDPDAKKPEDWDEEMDGEWE---------------- 262

  Fly   375 KWKAPLIPNPNYKGKWRAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSD 439
               .|:|.||.|||:|:...|:||:|:|.|...:|.||::..|...:.....:.:||:||.:.|.
  Rat   263 ---PPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSG 324

  Fly   440 ILFDNLIITDDVEVARDFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAIVALVAL 504
            .:|||.:||:|...|.:|...:                             ||:           
  Rat   325 TIFDNFLITNDEAYAEEFGNET-----------------------------WGV----------- 349

  Fly   505 TIYCRFGTAKSQDSAAKKAAAEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQK 569
                            .|||  .|:..|.|.:::...|||.|:                 |:.::
  Rat   350 ----------------TKAA--EKQMKDKQDEEQRLKEEEEDK-----------------KRKEE 379

  Fly   570 SDLDDNEEESKAAESREPAQTEESNTKTRKRQARKE 605
            .:.:|.|:|....|..:....:|.:.:....||:.|
  Rat   380 EEAEDKEDEDDRDEDEDEEDEKEEDEEDATGQAKDE 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cnx99ANP_477157.1 Calreticulin 74..447 CDD:459737 133/382 (35%)
CalrNP_071794.1 N-domain 18..197 67/215 (31%)
Calreticulin 23..332 CDD:459737 133/382 (35%)
4 X approximate repeats 191..255 37/86 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..277 52/125 (42%)
P-domain 198..308 59/151 (39%)
Interaction with PPIB. /evidence=ECO:0000250 237..270 21/51 (41%)
3 X approximate repeats 259..297 19/56 (34%)
C-domain 309..416 34/182 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..416 19/85 (22%)
Prevents secretion from ER 413..416 1/3 (33%)

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