Protein Alignment Cnx99A and canx

DIOPT Version :10

• Sequence 1: NP_477157.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_998613.1
• Gene: canx / 406757
• ZFINID: ZDB-GENE-040426-2797
• Length: 600
• Species: Danio rerio
• Alignment Length: 621
• Identity: 310/621 - (49%)
• Similarity: 397/621 - (63%)
• Gaps: 57/621 - (9%)

  Fly    13 LALLFASSLLLLSAANAADLDTESDDFE---DGYVEDVQEEPAVIGGDEKLA---YESPVIDAK- 70
            :|||..|..|||.....|. :.|:||.|   :..::|:|||.  |..:|:.|   ..:|.:..|
Zfish     9 VALLSLSLCLLLMGPVRAQ-EEEADDMEMDVEDAIDDMQEED--IEEEEQKAPAPPSAPTVTYKA 70

  Fly    71 -----KFHFADHFDDVEESRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSK 130
                 :.:||:.||  :.:.:.|||||||||.|.|:|:||||.|..|..|......|.|||||||
Zfish    71 PEPMGEHYFAEAFD--KGTLQGWVLSQAKKDGIDEDIAKYDGKWEVEEMQDSKLPGDKGLVLKSK 133

  Fly   131 AKHAAIAAPLRKPFEFKSDKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQLKAFNDKTPYTIM 195
            |||.||:|.|.:||.|.: |||:|||||..|.|.:|||:|:||||...|.: |:.|.||||||||
Zfish   134 AKHHAISALLLRPFTFDT-KPLIVQYEVNFQTGIDCGGAYVKLLSQTPDLD-LEEFVDKTPYTIM 196

  Fly   196 FGPDKCGNDVKMHFIFRHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVD 260
            |||||||.|.|:||||||.||..|...|||..||.:.|...:.||..|||.||:.|||:|||.:|
Zfish   197 FGPDKCGEDYKLHFIFRHKNPKTGEFEEKHAKKPDSDLRSYYTDKKTHLYTLVLNPDNTFEILID 261

  Fly   261 HKIINEGSLLTDFKPPVNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAV 325
            ..::|.||||.|..|||||||||:||:|||||.||||.||.||.|.||||||||||.::.|.|||
Zfish   262 QTVVNSGSLLNDVTPPVNPPAEIEDPDDHKPEDWDERPKIQDPDAVKPEDWDEDAPAKIADEDAV 326

  Fly   326 MPNGWLEDEPDMIFDPTATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKW 390
            .|:|||:|||:.|.||.|.||||||.::|||||||.:.|||||.|||||.|:.|:|.||||||||
Zfish   327 KPDGWLDDEPEYISDPDAVKPEDWDEDMDGEWEAPQIPNPVCETAPGCGAWERPMIDNPNYKGKW 391

  Fly   391 RAPMIENPNYQGKWAPRKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVAR 455
            ::|||:||||||.|.|||||||||||||.||:|||.||||||||||||||.|||..||.|..||.
Zfish   392 KSPMIDNPNYQGVWKPRKIPNPDFFEDLHPFRMTPFSAVGLELWSMSSDIFFDNFFITSDRNVAE 456

  Fly   456 DFAANSFDIKRRYIDRESDSFVNKVVELAKANPSIWGIGLVAI-VALVALTIYCRFGTAKSQDSA 519
            .:|.:.:.:|:..........||:::..|:..|.:|.:.::.: :.||.:.::|..|    :.|:
Zfish   457 RWANDGWGLKKAAEGAAEPGLVNQMITAAEERPWLWIVYVLTVALPLVLIIVFCCTG----KKSS 517

  Fly   520 AKKAAAEAKKSDDPQP------------DDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSDL 572
            |...||:.||:|:|||            |:||||::..:|.:.||...:.|.        :..|.
Zfish   518 ASTPAAKYKKTDEPQPDVKEEAEEEEAKDEEPEAKKSEEEDSTGDGDGDDTA--------ENGDK 574

  Fly   573 DDNEEESKAAES---REPAQTEESNTKTRKRQARKE 605
            |||....|:.:.   |.|          |.|::||:
Zfish   575 DDNTSNEKSEDDILRRSP----------RNRKSRKD 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_477157.1	Calreticulin	74..447	CDD:459737	243/372 (65%)
canx	NP_998613.1	Calreticulin	79..448	CDD:459737	243/372 (65%)