Protein Alignment Cnx99A and Clgn

DIOPT Version :10

• Sequence 1: NP_477157.1
• Gene: Cnx99A / 44643
• FlyBaseID: FBgn0015622
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_011246598.1
• Gene: Clgn / 12745
• MGIID: 107472
• Length: 615
• Species: Mus musculus
• Alignment Length: 614
• Identity: 279/614 - (45%)
• Similarity: 371/614 - (60%)
• Gaps: 44/614 - (7%)

  Fly    22 LLLSAANAADLD--TESDDFEDGYVE-DVQEEPAVIGGDEKLAYESPVIDAKKFHFADHFDDVEE 83
            ||....||..:|  .|.:||.:...| ::::||:  .|..|.....|:   .:.:|.:.||  ..
Mouse    16 LLFITVNADFMDDGVEVEDFSENSDESNIKDEPS--SGTFKYKTPQPI---GEVYFTETFD--SG 73

  Fly    84 SRKRWVLSQAKKDDIAEEISKYDGIWNWESPQRIVWANDLGLVLKSKAKHAAIAAPLRKPFEFKS 148
            :...||||:|||||:..||:.|||.|..|..:......|.||||||||||.||||.|.|||.| :
Mouse    74 NLAGWVLSKAKKDDMDSEIAIYDGRWEIEELKENQVPGDRGLVLKSKAKHHAIAAVLEKPFIF-A 137

  Fly   149 DKPLVVQYEVTLQEGQECGGSYLKLLSAGKDTEQ--LKAFNDKTPYTIMFGPDKCGNDVKMHFIF 211
            ||||:|||||..|:|.:|||:|:|||:   ||..  |:.|.|||.|||||||||||.|.|:|.||
Mouse   138 DKPLIVQYEVNFQDGIDCGGAYIKLLA---DTGDLILENFYDKTSYTIMFGPDKCGEDYKLHLIF 199

  Fly   212 RHVNPINGTITEKHCNKPKNRLEEPFKDKLPHLYQLVVRPDNSFEIRVDHKIINEGSLLTDFKPP 276
            ||.:|..|...|||...|...|:|.|.|:..|||.||:.||::||:.:|.|::|:|:||.|..||
Mouse   200 RHKHPKTGVFEEKHAKPPDVDLKEFFTDRKTHLYTLVMNPDDTFEVLIDQKVVNQGTLLDDVVPP 264

  Fly   277 VNPPAEIDDPNDHKPESWDEREKIPDPTAHKPEDWDEDAPPQLPDTDAVMPNGWLEDEPDMIFDP 341
            :|||.|||||:|.|||.||:|.|||||||.:||||||:.|.|:.|:.||.|:|||:|||..|.:|
Mouse   265 INPPREIDDPSDKKPEEWDDRAKIPDPTAVRPEDWDENEPAQIEDSSAVKPDGWLDDEPKFIPNP 329

  Fly   342 TATKPEDWDAEIDGEWEAPLVDNPVCEKAPGCGKWKAPLIPNPNYKGKWRAPMIENPNYQGKWAP 406
            .|.|||||..::|||||||.:.||.|:  .|||:||.|:|.||.|||.||.|||.||||||.|:|
Mouse   330 KAEKPEDWSDDMDGEWEAPHIPNPACQ--IGCGEWKPPMIDNPKYKGIWRPPMINNPNYQGLWSP 392

  Fly   407 RKIPNPDFFEDLKPFQMTPISAVGLELWSMSSDILFDNLIITDDVEVARDFAANSFDIKRRYIDR 471
            :||||||:|||..||.:|..||:|||||||:.||.|||.||..:.|||..:|.:.:::|....:.
Mouse   393 QKIPNPDYFEDDHPFLLTSFSALGLELWSMTPDIYFDNFIICSEKEVADQWATDGWELKIMVANA 457

  Fly   472 ESDSFVNKVVELAKANPSIWGIGLVAI---VALVALTIYCRFGTAKSQDSAAK---------KAA 524
            .....:.::|..|:..|.:|.:.||..   |||||...:.|....|.:|:..|         |||
Mouse   458 NEPGVLRQLVIAAEERPWLWLMYLVMAGLPVALVASFCWPRKVKKKYEDTGPKKTELCKLQSKAA 522

  Fly   525 AEAKKSDDPQPDDEPEAEEESDERAAGDTSKESTPLSASPKKNQKSD---LDDNEEESKAAES-- 584
            .|.:..::..|:...:.:||.....|...:.|...: ..|::..|.|   |:..||.||.::|
Mouse   523 LEQEAEEEKAPEKPEDVQEEKKPGEAEVVTVEKEVI-GEPEEKSKEDRETLEGQEEVSKLSKSGS 586

  Fly   585 --------REPAQTEESNTKTRKRQARKE 605
                    ..|...:......|||:.||:
Mouse   587 EDEMKDADESPGSGDAPLKSLRKRRVRKD 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cnx99A	NP_477157.1	Calreticulin	74..447	CDD:459737	219/374 (59%)
Clgn	XP_011246598.1	Calreticulin	66..433	CDD:459737	219/374 (59%)