Protein Alignment Smyd3 and smyd4

DIOPT Version :10

• Sequence 1: NP_524768.2
• Gene: Smyd3 / 44554
• FlyBaseID: FBgn0011566
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: XP_012812690.1
• Gene: smyd4 / 779741
• XenbaseID: XB-GENE-945037
• Length: 777
• Species: Xenopus tropicalis
• Alignment Length: 522
• Identity: 109/522 - (20%)
• Similarity: 202/522 - (38%)
• Gaps: 122/522 - (23%)

  Fly    35 IKRGQRILTEKPFAFVL---KSQYRLE--------RCDN----CL-EATKVLKCSNCRYVSYCHR 83
            |::|:.::.|:.||.|:   :.|:|.|        .||:    || .....|.|..|.:..||.:
 Frog   259 IEQGEVLIWEEAFASVIIPERKQWRKEIKWDTRITACDHYCHYCLNRVIASLPCQYCSFARYCSQ 323

  Fly    84 SCQMQAW-GQHKHECPFLKKVHPRVVPD---AARMLCRLILR-------------LEHGGDL--- 128
            .|..:|| ..|..||.         :.|   |..|.|...||             ||..|..
 Frog   324 ECMDKAWRSYHYIECS---------MGDLLLALGMFCHTALRAVLVAGCRLFSQSLEQTGSADAT 379

  Fly   129 -------IRGYYTEHGSRKFRDLMSHYAEIKNDPMRLEHLDSLHA----------VLTDMMAESP 176
                   .:..|.|.....::.:::.....:|.|...:.|..|.|          :..|:::.:.
 Frog   380 DKTKVCNSKNTYHEKYCSSYQSVVNLLPHTENHPAERKFLCGLTAAALYKKLCLIMAKDLVSSTS 444

  Fly   177 STVPNKTE----------------------LMSIY--GRLIT--------NGFNILDAEMN-SIA 208
            .|..:.|:                      ::.:|  .:.:|        :..:::.:..: .:|
 Frog   445 QTEKSLTKESGTIEDWSSVRQFLGPTVLRHMLQLYCNAQAVTALQENEDESSLSLVKSNKSIRLA 509

  Fly   209 TAIYLGVSITDHSCQPNAVATFEGNELHVHA-------IEDMECLDWSKIFISYIDLLNTPEQRR 266
            ||::..:|:.:|||.||...:|.|..:.|.|       .|...|....|:      .::..|:::
 Frog   510 TAVFPVLSLLNHSCDPNTTVSFTGRFVTVRANRPIRRDEEVTHCYGPHKL------RMDVAERQQ 568

  Fly   267 LDLKEHYYFLCVCSKCTDAKESKEMLAALCPNRNCGAGISVDRN-NC--PRC-----DAGISPKL 323
            | ||:.|:|:|.|..||:..:.|:.....||  .|.|.:..:.. .|  .||     ...::.:|
 Frog   569 L-LKDQYFFVCQCKACTEELKGKKTHGFFCP--LCKAQLEGEEALYCTGARCTYTASQTQLTSRL 630

  Fly   324 RNAFNEAMTLTRHNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAAIEVGKWSDA 388
            ....|..........:|..|.|.:.:.. ||.:........::...:.:|...:|....|.|..|
 Frog   631 NQLGNHIQIAKVQLQDNKTDNAKMTLMS-CLSEAECFLSQDHLLLGEIMDHLAQAEASDGNWKAA 694

  Fly   389 LDYGQRLLPGFRKYHGPWNPLLGLLHMKLGKIQLYEGHS-KEALHHLEEAQRILTVTHGRDHRLL 452
            ..:.::.:...:.::|..:..||....||.:| |:.|.. .:|:..:.|||::|::.:|.||.|:
 Frog   695 AGHLRKSISIVKVHYGSSSMELGHELFKLAQI-LFNGFEVPDAMRTIMEAQKVLSMHYGPDHNLV 758

  Fly   453 TE 454
            .|
 Frog   759 QE 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	SET	34..284	CDD:394802	70/341 (21%)
		zf-MYND	60..97	CDD:460312	13/42 (31%)
		TPR_12	<383..441	CDD:315987	15/58 (26%)
smyd4	XP_012812690.1	TPR repeat	106..134	CDD:276809
		TPR repeat	143..173	CDD:276809
		SET_SMYD4	234..583	CDD:380934	69/339 (20%)
		zf-MYND	299..338	CDD:460312	11/38 (29%)