Protein Alignment Smyd3 and SMYD2

DIOPT Version :10

• Sequence 1: NP_524768.2
• Gene: Smyd3 / 44554
• FlyBaseID: FBgn0011566
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_064582.2
• Gene: SMYD2 / 56950
• HGNCID: 20982
• Length: 433
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 115/479 - (24%)
• Similarity: 212/479 - (44%)
• Gaps: 89/479 - (18%)

  Fly    21 CS-SKSKNLKNPAPQIKRGQRILTEKPFAFVLKSQYRLERCDNCLEATKVL-KCSNCRYVSYCHR 83
            || .|.:.|:...| .:.|..:.:...:|:||....|...|:.|....:.| ||..|:...||:.
Human    13 CSPGKGRGLRALQP-FQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNV 76

  Fly    84 SCQMQAWGQHKHEC-PFL---------------------KKVHPRVVPDAARMLCRLILRLEHGG 126
            .||.:.|..||.|| |.:                     :|:||...| :.::|.  :...|...
Human    77 ECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTP-SEKLLA--VKEFESHL 138

  Fly   127 DLIRGYYTEHGSRKFRDLMSHYAEIKNDPMRLEHLDSLHAVLTDMMAESPSTVPNKTELMSIYGR 191
            |.:        ..:.:||      |::|...|.|..|.|.           ..|:...|:.::.:
Human   139 DKL--------DNEKKDL------IQSDIAALHHFYSKHL-----------GFPDNDSLVVLFAQ 178

  Fly   192 LITNGFNILDAEMNSIATAIYLGVSITDHSCQPNAVATFEGNELHVHAIEDMECLDWSKIFISYI 256
            :..|||.|.|.|::.:.:||:..|::.:|||.||.:.|::|....|.|:::::  ...::|.|||
Human   179 VNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIK--PGEEVFTSYI 241

  Fly   257 DLLNTPEQRRLDLKEHYYFLCVCSKCTDAKESKEMLAALCPNRNCGAGISVDRNNCPRCDAGISP 321
            |||...|.|...|::.|:|.|.|.:||...:.|             |.:.:.:.:.|       |
Human   242 DLLYPTEDRNDRLRDSYFFTCECQECTTKDKDK-------------AKVEIRKLSDP-------P 286

  Fly   322 KLRNAFNEAMTLTRHNLENMKDVAY-------LDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAA 379
            | ..|..:.:...|:.:|..:...:       |::|::..:|.:.||...||:.:..:..|....
Human   287 K-AEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVC 350

  Fly   380 IEVGKWSDALDYGQRLLPGFRKYHGPWNPLLGLLHMKLGKIQLYEGHSKEALHHLEEAQRILTVT 444
            :.:..|..||.|||:::..:.|::..::..:..:.:|||::.:...|.......|::|..|:.|.
Human   351 LYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVA 415

  Fly   445 HGRDHRLLTEQLYMLVLQARQEAH 468
            ||:||..::|      ::...|:|
Human   416 HGKDHPYISE------IKQEIESH 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	SET	34..284	CDD:394802	71/272 (26%)
		zf-MYND	60..97	CDD:460312	13/37 (35%)
		TPR_12	<383..441	CDD:315987	13/57 (23%)
SMYD2	NP_064582.2	SET_SMYD2	7..269	CDD:380979	76/286 (27%)
		zf-MYND	52..90	CDD:460312	13/37 (35%)