Protein Alignment Smyd3 and Smyd2

DIOPT Version :10

• Sequence 1: NP_524768.2
• Gene: Smyd3 / 44554
• FlyBaseID: FBgn0011566
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_996733.1
• Gene: Smyd2 / 289372
• RGDID: 727785
• Length: 433
• Species: Rattus norvegicus
• Alignment Length: 479
• Identity: 118/479 - (24%)
• Similarity: 213/479 - (44%)
• Gaps: 89/479 - (18%)

  Fly    21 CSS-KSKNLKNPAPQIKRGQRILTEKPFAFVLKSQYRLERCDNCLEATKVL-KCSNCRYVSYCHR 83
            ||: |.:.|:...| ...|..:.:...:|.||....|...|:.|....:.| ||..|:...||..
  Rat    13 CSAGKGRGLRALRP-FHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDV 76

  Fly    84 SCQMQAWGQHKHECPFL----------------------KKVHPRVVPDAARMLCRLILRLEHGG 126
            .||.:.|..||.||..:                      :|:||...| :.::|.
  Rat    77 ECQKEDWPLHKLECSSMVVFGENWNPSETVRLTARILAKQKMHPERTP-SEKLLA---------- 130

  Fly   127 DLIRGYYTEHGSRKFRDLMSHYAEIKNDPMRLEHLD--SLHAVLTDMMAESPSTVPNKTELMSIY 189
                          .|:..||..::.|:...|...|  :||...:..:     ..|:.:.|:.::
  Rat   131 --------------VREFESHLDKLDNEKKDLIQSDIAALHQFYSKHL-----EFPDHSSLVVLF 176

  Fly   190 GRLITNGFNILDAEMNSIATAIYLGVSITDHSCQPNAVATFEGNELHVHAIEDMECLDWSKIFIS 254
            .::..|||.|.|.|::.:.:||:..|::.:|||.||.:.|::|....|.|::::...|  ::|.|
  Rat   177 AQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGD--EVFTS 239

  Fly   255 YIDLLNTPEQRRLDLKEHYYFLCVCSKCTDAKESKEMLAALCPNRNCGAGISVDR-NNCPRCDAG 318
            |||||...|.|...|::.|:|.|.|.:||...:.|             |.:.:.: :|.|:.:|
  Rat   240 YIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDK-------------AKVEIRKLSNPPQAEA- 290

  Fly   319 ISPKLRNAFN--EAMTLTRHNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAAIE 381
            |...:|.|.|  |.....:|.....:   .|::|::..:|.:.||...||:.:..:..|....:.
  Rat   291 IRDMVRYARNVIEEFRRAKHYKSPSE---LLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLY 352

  Fly   382 VGKWSDALDYGQRLLPGFRKYHGPWNPLLGLLHMKLGKIQLYEGHSKEALHH--LEEAQRILTVT 444
            :..|..||.|||:::..:.|::..::..:..:.:|||:  ||.|...:|...  |::|..|:.:.
  Rat   353 MQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGR--LYMGLENKAAGEKALKKAIAIMEIA 415

  Fly   445 HGRDHRLLTEQLYMLVLQARQEAH 468
            ||:||..::|      ::...|:|
  Rat   416 HGKDHPYISE------IKQEIESH 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	SET	34..284	CDD:394802	69/274 (25%)
		zf-MYND	60..97	CDD:460312	13/37 (35%)
		TPR_12	<383..441	CDD:315987	16/59 (27%)
Smyd2	NP_996733.1	SET_SMYD2	7..269	CDD:380979	74/288 (26%)
		zf-MYND	52..90	CDD:460312	13/37 (35%)
		TPR_10	388..422	CDD:463861	13/35 (37%)