Protein Alignment Smyd3 and SMYD1

DIOPT Version :10

• Sequence 1: NP_524768.2
• Gene: Smyd3 / 44554
• FlyBaseID: FBgn0011566
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_938015.1
• Gene: SMYD1 / 150572
• HGNCID: 20986
• Length: 490
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 112/456 - (24%)
• Similarity: 198/456 - (43%)
• Gaps: 71/456 - (15%)

  Fly    41 ILTEKPFAFVLKSQYRLERCDNCLE-ATKVLKCSNCRYVSYCHRSCQMQAWGQHKHECPFLKKVH 104
            |..|:.::.|:........|..|.: ..|:.:|..|::..||.|:||..||..||:||..:|: :
Human    33 IFAERAYSAVVFDSLVNFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-Y 96

  Fly   105 PRVVPDAARMLCRLILRLEHGGDLIRGYYTEHGSRKFRDL---MSHYAEIKNDPMRLEHLDSLHA 166
            .:|..:..|:..|::.|:|..|..:    ||.......||   :.|:.|.:...:|::
Human    97 GKVPNENIRLAARIMWRVEREGTGL----TEGCLVSVDDLQNHVEHFGEEEQKDLRVD------- 150

  Fly   167 VLTDMMAESPSTVPNKTELMS-IYGRLITNGFNILDAE-MNSIATAIYLGVSITDHSCQPNAVAT 229
            |.|.:....|.:.....:.:| |:|.:..|||.:.|.. :.::...|:..:.:.:|.|.||....
Human   151 VDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVI 215

  Fly   230 F-EGNE------LHVHAIEDMECL----DWSKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKC- 282
            | .||.      .|.....::..|    :..::.:||||.||..|:|:..||:.|||.|.|..|
Human   216 FNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQ 280

  Fly   283 ------------TDAKESKEMLAALCPNRNCGAGISVDRNNCPRCDAGISPKLRNAFNEAMTLTR 335
                        .:.|.|:|::..:         |...::...:.|...|..|   ::|.:.|
Human   281 KKLKDDLFLGVKDNPKPSQEVVKEM---------IQFSKDTLEKIDKARSEGL---YHEVVKL-- 331

  Fly   336 HNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAAIEVGKWSDALDYGQRLLPGFR 400
                          |:.||:||..||...|::.::.|....|....:..:.:|..|.:|::.|:.
Human   332 --------------CRECLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYM 382

  Fly   401 KYHGPWNPLLGLLHMKLGKIQLYEGHSKEALHHLEEAQRILTVTHGRDHRLLTEQLYMLVLQARQ 465
            |.:.|.|..||:..|:.|....:.|:.:.....:.:|..||.||||..|. :|:.|..:.:|...
Human   383 KLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHP-ITKDLEAMRVQTEM 446

  Fly   466 E 466
            |
Human   447 E 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd3	NP_524768.2	SET	34..284	CDD:394802	69/272 (25%)
		zf-MYND	60..97	CDD:460312	14/37 (38%)
		TPR_12	<383..441	CDD:315987	13/57 (23%)
SMYD1	NP_938015.1	SET_SMYD1	7..281	CDD:380924	69/259 (27%)
		zf-MYND	52..90	CDD:460312	14/37 (38%)