DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smyd3 and SMYD4

DIOPT Version :10

Sequence 1:NP_524768.2 Gene:Smyd3 / 44554 FlyBaseID:FBgn0011566 Length:468 Species:Drosophila melanogaster
Sequence 2:NP_443160.2 Gene:SMYD4 / 114826 HGNCID:21067 Length:804 Species:Homo sapiens


Alignment Length:504 Identity:108/504 - (21%)
Similarity:177/504 - (35%) Gaps:140/504 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 CDNCLEAT-KVLKCSNCRYVSYCHRSCQMQAWG-QHKHECPF----------------------- 99
            |..||:.| ..:.|..|.|..||.:.|..|||. .|:.|||.                       
Human   296 CHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGF 360

  Fly   100 --LKKVHPRV----------VPDAARMLCRLILRL---EHGGDL---------IRGYYTEHGSRK 140
              ::|:..::          :|::...:..|...|   |..|::         |.|.|..:.:..
Human   361 EDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAV 425

  Fly   141 FRDLMSHYAEIKNDPMRLEH----------------LDSLHAVLTDMMAES--------PSTVPN 181
            | :|:.|..  .:.|   ||                ..||.|:.|:.:..|        |...|:
Human   426 F-NLLPHTE--NHSP---EHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPD 484

  Fly   182 KT-----------------ELMSIYGRLITNGFNILDAEMNSIATAIYLGVSITDHSCQPN---- 225
            .|                 :.|:........|..:.|:....:||.|:..:|:.:|||.||    
Human   485 VTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVS 549

  Fly   226 ---AVATFEGNELHVHAIEDMECLDWSKIFISYIDLLNTPEQRRLDLKEHYYFLCVCSKCTDAKE 287
               .|||...::......|.:.|....|..:..       .:|:..|:..|:|.|.|..|  ..|
Human   550 FISTVATIRASQRIRKGQEILHCYGPHKSRMGV-------AERQQKLRSQYFFDCACPAC--QTE 605

  Fly   288 SKEMLA-----ALCPNRNCGAGISVDRNNCPRC------DAGIS--------PKLRNAFNEAMTL 333
            :..|.|     |.|.| :|||.:..|  :..||      ::.:|        ..|:.....|..|
Human   606 AHRMAAGPRWEAFCCN-SCGAPMQGD--DVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKL 667

  Fly   334 TRHNLENMKDVAYLDVCKVCLDKQTGVFHPLNVWYVKTLDAAFEAAIEVGKWSDALDYGQRLLPG 398
            .|.. |..:.|..|..|:...:......|.:   ..:..|....|...:|.|..:..:.||.|..
Human   668 LRDG-ELERAVQRLSGCQRDAESFLWAEHAV---VGEIADGLARACAALGDWQKSATHLQRSLYV 728

  Fly   399 FRKYHGPWNPLLGLLHMKLGKIQLYEGHS-KEALHHLEEAQRILTVTHG 446
            ....|||.:..:|....||.:| .:.|.: .|||..:::|:.:|::..|
Human   729 VEVRHGPSSVEMGHELFKLAQI-FFNGFAVPEALSTIQKAEEVLSLHCG 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smyd3NP_524768.2 SET 34..284 CDD:394802 65/320 (20%)
zf-MYND 60..97 CDD:460312 14/38 (37%)
TPR_12 <383..441 CDD:315987 17/58 (29%)
SMYD4NP_443160.2 NlpI <66..>171 CDD:443815
TPR repeat 68..96 CDD:276809
TPR repeat 101..135 CDD:276809
TPR repeat 143..171 CDD:276809
SET 239..>269 CDD:394802
zf-MYND 296..335 CDD:460312 14/38 (37%)
SET_SMYD4 404..602 CDD:380934 41/210 (20%)
TPR_12 660..726 CDD:315987 14/69 (20%)
TPR_12 698..771 CDD:315987 19/73 (26%)
Blue background indicates that the domain is not in the aligned region.

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