Protein Alignment Hnf4 and nr2c1

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001018458.1
• Gene: nr2c1 / 553649
• ZFINID: ZDB-GENE-041210-198
• Length: 600
• Species: Danio rerio
• Alignment Length: 580
• Identity: 138/580 - (23%)
• Similarity: 218/580 - (37%)
• Gaps: 197/580 - (33%)

  Fly   122 AGGGS-----ASSGSNNNNSMFSPNNN-------LSGSGSGTNS--------SQQQLQ-----QQ 161
            ||.|.     |:....|...:|....|       .|..||..|.        |.||:|     ..
Zfish    38 AGAGKQQFILANLDYPNQEKLFIKQENSPAKVILTSSDGSAVNQLLFASPELSGQQIQFVTDGSD 102

  Fly   162 QQQQSPTV--CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRY 224
            |....|.|  |.:|||:|:|:||||.||:||||||:||:|||..||||.:..||::|..||:|:|
Zfish   103 QGSMKPPVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSIRKNLVYTCRGSGECVINKHHRNRCQY 167

  Fly   225 CRLRKCFKAGMKKEAVQNER-----------------DRISCRRT-------------------- 252
            |||::|...|||:::||.||                 ::|..|:.
Zfish   168 CRLQRCMALGMKQDSVQCERKPVEVSREKPANCAPSIEKIYIRKNLCSPLAAMPTFVSQKESTRP 232

  Fly   253 ----------------------------------------------------------------- 252
                                                                             
Zfish   233 TSLLDSNMLLNIQQSISKLDNTILIPSSPDQNDSSQGDLGTLANVVTSLGRLNKSREMMDSSTDL 297

  Fly   253 ------SNDDP-------DPGNGL-----SVISLVKAENESRQSKAGAAMEPNINED-------- 291
                  ||||.       :..|.:     ::..::|||....:..|..|:....:|.
Zfish   298 SGIDTMSNDDSVMTDIQREESNDVTRAFDTLTKVLKAEESCGEEVADGAVAVRDDEQTSALLELE 362

  Fly   292 ----------------LSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHA 340
                            |....|.::|.:|||..:.|...:.||:.||||..|..::.:.|::|..
Zfish   363 GPLLSDMHVPFKLMMPLPMPDFLNLNYICESASRLLFLSMHWARSIPAFQALGSENGITLMKACW 427

  Fly   341 GEHLLLGLSRRS--MHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARI-----IDELVTVMK 398
            .|...|||::.|  |:::.:|     ..|..|....|....|...|:...:     :.|....|.
Zfish   428 NELFALGLAQCSHIMNVETIL-----TAIINHLQTSLDEEKLSPERVKQVMEHIWRMQEFCNSMS 487

  Fly   399 DVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILP 463
            .:..|..|:|.:||:|.|.|:...::...:|:..:.:....|:||:|....|...|..::|:.||
Zfish   488 RMSPDAYEYAYLKAVVLFSPDHSAVDGTLQIERFQEKAYMELQDYVSKVYPEDTYRLSKLLVRLP 552

  Fly   464 VLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSPPNQSNDYQSPTHTG 523
            .|:.::..:.|::.||.:.|...|||::..:|              ..:|.||.|...:|
Zfish   553 ALRLMSAAVTEELFFAGLIGNVQIDSIIPYIL--------------KMESTDYNSQPISG 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	45/91 (49%)
		NR_LBD_HNF4_like	264..494	CDD:132729	62/260 (24%)
nr2c1	NP_001018458.1	NR_DBD_TR2_like	108..194	CDD:143525	47/85 (55%)
		NR_LBD_TR2_like	365..586	CDD:132750	57/239 (24%)