Protein Alignment Hnf4 and Nr2c2

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_038964194.1
• Gene: Nr2c2 / 50659
• RGDID: 3201
• Length: 629
• Species: Rattus norvegicus
• Alignment Length: 637
• Identity: 153/637 - (24%)
• Similarity: 252/637 - (39%)
• Gaps: 194/637 - (30%)

  Fly    22 LLRGKVGGGRVAVAAAEEAEAGRRRRRRDSSASRTASSDESESHIMHADALASAYPAASQPHSPI 86
            |::.:||..:|       ||..|.:..|..|...|:.|...:  |:..|:      |.:.|.. |
  Rat     8 LVQHRVGTQQV-------AEVPRTQTSRPESPGMTSPSPRIQ--IISTDS------AVASPQR-I 56

  Fly    87 GLALSPNGGG----LGLSNSSNQSSENFALCNGNGNAGSAGGGSASSGSNNNNS----MFSPNNN 143
            .:......|.    :...::|..|.:.|.|.:.:|    ||.|.....|...:|    :|:.::|
  Rat    57 QIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDG----AGTGKVILASPETSSAKQLIFTTSDN 117

  Fly   144 LSGSGSG------TNSSQQQLQQQQQQQSPTV---CAICGDRATGKHYGASSCDGCKGFFRRSVR 199
            |.   .|      .::|.::|..:...|.|.|   |.:|||:|:|:||||.||:||||||:||||
  Rat   118 LV---PGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVR 179

  Fly   200 KNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNER-------------------- 244
            ||..|:||.:::|:::|..||:|::|||:||.:.|||.|:||:||
  Rat   180 KNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKI 244

  Fly   245 ------------------DRISCRRTSNDDP------------DPGNGLSVISLVKAENESRQSK 279
                              |:...|:|...||            :.|   :|:....::.|:.|..
  Rat   245 YIRKDLRSPLIATPTFVADKDGSRQTGLLDPGMLVNIQQPLIREDG---TVLLATDSKAETSQGA 306

  Fly   280 AGAAME-----PNINEDLSN--------------------------------------------- 294
            .|....     .|::|.|:|
  Rat   307 LGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDAS 371

  Fly   295 ---------------------------------------KQFASINDVCESMKQQLLTLVEWAKQ 320
                                                   .::.:::.:|||..:.|...:.||:.
  Rat   372 GGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARS 436

  Fly   321 IPAFNELQLDDQVALLRAHAGEHLLLGLSR--RSMHLKDVLLLSNNCVITRHCPDPLVSPNLDIS 383
            ||||..|..|...:|:||...|...|||::  :.|.|..:|     ..|..|..:.:....|...
  Rat   437 IPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTIL-----AAIVNHLQNSIQEDKLSGD 496

  Fly   384 RIGARI-----IDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDY 443
            ||...:     :.|....|..:.||..|:|.:||:|.|.|:..||....:|:..:.:....|:||
  Rat   497 RIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDY 561

  Fly   444 ISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEML 495
            :.....|...|...||:.||.|:.::..:.|::.|..:.|...|||::..:|
  Rat   562 VQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYIL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	45/112 (40%)
		NR_LBD_HNF4_like	264..494	CDD:132729	65/325 (20%)
Nr2c2	XP_038964194.1	NR_DBD_TR2_like	145..231	CDD:143525	46/85 (54%)
		NR_LBD_TR2_like	394..615	CDD:132750	58/225 (26%)