Protein Alignment Hnf4 and Hr78

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_730636.1
• Gene: Hr78 / 40378
• FlyBaseID: FBgn0015239
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 132/614 - (21%)
• Similarity: 212/614 - (34%)
• Gaps: 251/614 - (40%)

  Fly   108 ENFALCNGNGNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAI 172
            |.|.....|......||||||.|:.      .|...: |.|:|.:::          .|..:|.:
  Fly     7 ETFIKSEENRAMPLIGGGSASGGTP------LPGGGV-GMGAGASAT----------LSVELCLV 54

  Fly   173 CGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKK 237
            |||||:|:||||.||:||||||:||:||...|.||.|.||.|.|..||:|::|||:||..:||:.
  Fly    55 CGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGAMNCEVTKHHRNRCQFCRLQKCLASGMRS 119

  Fly   238 EAVQNERDRISCRRT-------SNDDPDPGNGLSVISLVKA-----ENESRQSKAGAAMEP---- 286
            ::||:||..|..|:.       |:.....|||.|.....|:     ..:....||.:|..|
  Fly   120 DSVQHERKPIVDRKEGIIAAAGSSSTSGGGNGSSTYLSGKSGYQQGRGKGHSVKAESAATPPVHS 184

  Fly   287 ------NINEDL----------------------------------------------------- 292
                  |:||::
  Fly   185 APATAFNLNENIFPMGLNFAELTQTLMFATQQQQQQQQQHQQSGSYSPDIPKADPEDDEDDSMDN 249

  Fly   293 ---------------SNKQFASIN---------------------DV------------------ 303
                           :|.|..:.|                     |:
  Fly   250 SSTLCLQLLANSASNNNSQHLNFNAGEVPTALPTTSTMGLIQSSLDMRVIHKGLQILQPIQNQLE 314

  Fly   304 ----------CES----------------------------------------MKQQLLTLVEWA 318
                      |:|                                        .:|.|||.|:.|
  Fly   315 RNGNLSVKPECDSEAEDSGTEDAVDAELEHMELDFECGGNRSGGSDFAINEAVFEQDLLTDVQCA 379

  Fly   319 ---------------------------------KQIPAFNELQLDDQVALLRAHAGEHLLLGLSR 350
                                             :::|.|.:|:...||.|||......:.:.|::
  Fly   380 FHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQ 444

  Fly   351 RSMHLKDVLLLSNNCVITRHCPD-PLVSPNLDISRIG--ARIIDELVTVMKDVGIDDTEFACIKA 412
            ....|....::......||...| ..:.| |.||::.  .|.:.:.|..::.:.:.|.||..::.
  Fly   445 CQGQLSVPTIIGQFIQSTRQLADIDKIEP-LKISKMANLTRTLHDFVQELQSLDVTDMEFGLLRL 508

  Fly   413 LVFFDPNAKGLNEPHRIKSLRHQI-------LNNLEDYISDRQYESRG---RFGEILLILPVLQS 467
            ::.|:|.   |.:..:.:|||..:       |::|.     ||....|   ||..::..|..|.|
  Fly   509 ILLFNPT---LLQQRKERSLRGYVRRVQLYALSSLR-----RQGGIGGGEERFNVLVARLLPLSS 565

  Fly   468 ITWQMIEQIQFAKIFGVAHIDSLLQEMLL 496
            :..:.:|::.||.:.|...:|:|:..:|:
  Fly   566 LDAEAMEELFFANLVGQMQMDALIPFILM 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	44/74 (59%)
		NR_LBD_HNF4_like	264..494	CDD:132729	65/447 (15%)
Hr78	NP_730636.1	NR_DBD_TR2_like	47..133	CDD:143525	47/85 (55%)
		NR_LBD_TR2_like	372..595	CDD:132750	50/232 (22%)