DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hnf4 and Rxrb

DIOPT Version :10

Sequence 1:NP_723413.1 Gene:Hnf4 / 44544 FlyBaseID:FBgn0004914 Length:732 Species:Drosophila melanogaster
Sequence 2:XP_006256022.2 Gene:Rxrb / 361801 RGDID:3611 Length:625 Species:Rattus norvegicus


Alignment Length:554 Identity:181/554 - (32%)
Similarity:264/554 - (47%) Gaps:122/554 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 VRKSGRVKISSRDRVAVGNILLRGKVGGGRVAVAAAE----EAEAGRRRRRRDSSASRTASSDES 62
            |||.....::||.|        |.:......|.||.|    |.|.|...|.....:.|.:.|.:|
  Rat   127 VRKEMHCGVASRWR--------RRRPWLDPAAAAAGEQQTLEPEPGEAGRDGMGDSGRDSRSPDS 183

  Fly    63 ESHIMHADALASAYPAAS---QPHSPIG----LALSPNGGGLGLSNSSNQSSENFALCNGNGNAG 120
            .|    .:.|:...|.:|   .||:|..    :...|.|....:.:||               .|
  Rat   184 SS----PNPLSQGIPPSSPPGPPHTPSAPPPPMPPPPLGSPFPVISSS---------------MG 229

  Fly   121 SAG-------GGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTV--------- 169
            |.|       |.|....|...||..|    |.|.|||          ..:...|.|         
  Rat   230 SPGLPPPAPPGFSGPVSSPQINSTVS----LPGGGSG----------PPEDVKPPVLGVRGLHCP 280

  Fly   170 ------------CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQC 222
                        |||||||::|||||..||:||||||:|::||:..|:||..::|.|||.:||:|
  Rat   281 PPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRC 345

  Fly   223 RYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNG----LSVISLVKAENESRQSK---- 279
            :|||.:||...|||:||||.||.|   .:..:.|.|...|    :.|..:::||....|..    
  Rat   346 QYCRYQKCLATGMKREAVQEERQR---GKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGV 407

  Fly   280 ------AGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRA 338
                  .|:...||          ..:.::|::..:||.|||||||:||.|:.|.|||||.||||
  Rat   408 EGPGGTGGSGSSPN----------DPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRA 462

  Fly   339 HAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGA-------RIIDELVTV 396
            ...|.|:...|.||:.::|.:||:....:.|:        :...:.:||       |::.|||:.
  Rat   463 GWNELLIASFSHRSIDVRDGILLATGLHVHRN--------SAHSAGVGAIFDRSLSRVLTELVSK 519

  Fly   397 MKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLI 461
            |:|:.:|.||..|::|::.|:|:||||:.|..::.||.::..:||.|...:..|.:|||.::||.
  Rat   520 MRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLR 584

  Fly   462 LPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEML 495
            ||.|:||..:.:|.:.|.|:.|...||:.|.|||
  Rat   585 LPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hnf4NP_723413.1 NR_DBD_HNF4A 170..245 CDD:143518 46/74 (62%)
NR_LBD_HNF4_like 264..494 CDD:132729 82/246 (33%)
RxrbXP_006256022.2 None

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