Protein Alignment Hnf4 and rxrbb

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_571313.1
• Gene: rxrbb / 30486
• ZFINID: ZDB-GENE-990415-242
• Length: 422
• Species: Danio rerio
• Alignment Length: 459
• Identity: 160/459 - (34%)
• Similarity: 242/459 - (52%)
• Gaps: 86/459 - (18%)

  Fly    77 PAASQPHSPIGLALSPNGGGLGLSNSSNQSSENFALCNGNGNAGSAGGGSASSGSNNN---NSMF 138
            |:.|...||:....||      ||          |:.:..|:.|..|..|...|..:|   ||..
Zfish     6 PSTSAVSSPVSSVDSP------LS----------AVSSSIGSPGVPGTPSIGYGPISNSQINSSM 54

  Fly   139 S---------------PNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCD 188
            |               |....|.||||...||:::           |||||||::|||||..||:
Zfish    55 SVSRLHAVSSSDDVKPPFGLKSVSGSGPMLSQKRM-----------CAICGDRSSGKHYGVYSCE 108

  Fly   189 GCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDR------- 246
            ||||||:|:|||:..||||..:.|:|||.:||:|:|||.:||...|||:||||.||.:
Zfish   109 GCKGFFKRTVRKDLSYTCRDNKECLVDKRQRNRCQYCRYQKCLAMGMKREAVQEERQKNKERDGD 173

  Fly   247 ISCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAME--PNINEDLSNKQFASINDVCESMKQ 309
            ..|..::|::      :.|..:::||         .|:|  .:::.|.:......:.::|::..:
Zfish   174 YECSSSANEE------MPVEKILEAE---------TAVEHRTDLHSDATGSPNDPVTNICQAADK 223

  Fly   310 QLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCP-- 372
            ||.|||||||::|.|:::.|||||.||||...|.|:...|.||:.:||.:||:...    |.|
Zfish   224 QLFTLVEWAKRVPHFSDVPLDDQVILLRAGWNELLIAAFSHRSISVKDEILLATGL----HVPKE 284

  Fly   373 -----------DPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEP 426
                       |...|.:.::..:..|::.|||..|:|:.:|.||..|::|:|.|:|:||||...
Zfish   285 STHNLGVEAFFDRESSHSAEVGALFDRVLTELVCKMRDMQMDKTELGCLRAIVLFNPDAKGLTSS 349

  Fly   427 HRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLL 491
            ..::.||.::..:||.|...:..:.:|||.::||.||.|:||..:.:|.:.|.|:.|...||:.|
Zfish   350 SEVELLREKVYASLESYCKQKYPDQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGNTPIDTFL 414

  Fly   492 QEML 495
            .|||
Zfish   415 MEML 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	48/74 (65%)
		NR_LBD_HNF4_like	264..494	CDD:132729	80/244 (33%)
rxrbb	NP_571313.1	Modulating. /evidence=ECO:0000250	1..89		26/98 (27%)
		Nuc_recep-AF1	<21..77	CDD:463363	14/71 (20%)
		NR_DBD_RXR	89..164	CDD:143514	47/85 (55%)
		Hinge. /evidence=ECO:0000250	156..178		8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..182		4/20 (20%)
		NR_LBD_RXR_like	183..403	CDD:132741	75/238 (32%)