Protein Alignment Hnf4 and Nr2c2

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001334271.1
• Gene: Nr2c2 / 22026
• MGIID: 1352466
• Length: 629
• Species: Mus musculus
• Alignment Length: 555
• Identity: 136/555 - (24%)
• Similarity: 223/555 - (40%)
• Gaps: 176/555 - (31%)

  Fly   101 NSSNQSSENFALCNGNGNAGSAGGGSASSGSNNNNS----MFSPNNNLSGSGSG------TNSSQ 155
            ::|..|.:.|.|.:.:|    ||.|.....|...:|    :|:.::||.   .|      .::|.
Mouse    75 DASGSSKQQFILTSPDG----AGTGKVILASPETSSAKQLIFTTSDNLV---PGRIQIVTDSASV 132

  Fly   156 QQLQQQQQQQSPTV---CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKD 217
            ::|..:...|.|.|   |.:|||:|:|:||||.||:||||||:||||||..|:||.:::|:::|.
Mouse   133 ERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKH 197

  Fly   218 KRNQCRYCRLRKCFKAGMKKEAVQNER-------------------------------------- 244
            .||:|::|||:||.:.|||.|:||:||
Mouse   198 HRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVA 262

  Fly   245 DRISCRRTSNDDPDPGNGL-------------SVISLVKAENESRQSKAGAAME-----PNINED 291
            |:...|:|...||    |:             :|:....::.|:.|...|....     .|::|.
Mouse   263 DKDGARQTGLLDP----GMLVNIQQPLIREDGTVLLAADSKAETSQGALGTLANVVTSLANLSES 323

  Fly   292 LSN-------------------------------------------------------------- 294
            |:|
Mouse   324 LNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPII 388

  Fly   295 ----------------------KQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLR 337
                                  .::.:::.:|||..:.|...:.||:.||||..|..|...:|:|
Mouse   389 EVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVR 453

  Fly   338 AHAGEHLLLGLSR--RSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARI-----IDELVT 395
            |...|...|||::  :.|.|..:|     ..|..|..:.:....|...||...:     :.|...
Mouse   454 ACWNELFTLGLAQCAQVMSLSTIL-----AAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCN 513

  Fly   396 VMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILL 460
            .|..:.||..|:|.:||:|.|.|:..||....:|:..:.:....|:||:.....|...|...||:
Mouse   514 SMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILV 578

  Fly   461 ILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEML 495
            .||.|:.::..:.|::.|..:.|...|||::..:|
Mouse   579 RLPALRLMSSNITEELFFTGLIGNVSIDSIIPYIL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	45/112 (40%)
		NR_LBD_HNF4_like	264..494	CDD:132729	65/325 (20%)
Nr2c2	NP_001334271.1	NR_DBD_TR2_like	145..231	CDD:143525	46/85 (54%)
		NR_LBD_TR2_like	394..615	CDD:132750	58/225 (26%)